Thrombosis and Haemostasis

Thrombosis and Haemostasis

Research Topics uitklapper, klik om te openen

Disease mechanisms in (immuno)thrombosis and bleeding disorders. Developing new diagnostic tools and improving on current diagnostics. Developing innovative therapeutics. Our research is directly linked to clinical practice through continuous interaction with the Van Creveldkliniek and Clinical Diagnostics in our hospital. Societal impact is made through knowledge utilization and public-private partnership programs.

Key Publications uitklapper, klik om te openen

Scientific:

1. van Moorsel MVA, Poolen G, Koekman CA, Verhoef S, de Maat S, Barendrecht A, van Kleef ND, Meijers JCM, Schiffelers R, Maas C, Urbanus RT. VhH anti-thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow. J Thromb Haemost. 2022 Feb 16. doi: 10.1111/jth.15674. Epub ahead of print. PMID: 35170225.
2. de Maat S, Clark CC, Barendrecht AD, Smits S, van Kleef ND, El Otmani H, Waning M, van Moorsel M, Szardenings M, Delaroque N, Vercruysse K, Urbanus RT, Sebastian S, Lenting PJ, Hagemeyer C, Renné T, Vanhoorelbeke K, Tersteeg C, Maas C. Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis. Blood. 2022 Jan 27;139(4):597-607. doi: 10.1182/blood.2021011776. PMID: 34752601.
3. Noordermeer T, Molhoek JE, Schutgens REG, Sebastian SAE, Drost-Verhoef S, van Wesel ACW, de Groot PG, Meijers JCM, Urbanus RT. Anti-β2-glycoprotein I and anti-prothrombin antibodies cause lupus anticoagulant through different mechanisms of action. J Thromb Haemost. 2021 Apr;19(4):1018-1028. doi: 10.1111/jth.15241. Epub 2021 Feb 9. PMID: 33421291; PMCID: PMC8048633.
4. Sanrattana W, Smits S, Barendrecht AD, van Kleef ND, El Otmani H, Zivkovic M, Roest M, Renné T, Clark CC, de Maat S, Maas C. Targeted SERPIN (TaSER): A dual-action antithrombotic agent that targets platelets for SERPIN delivery. J Thromb Haemost. 2022 Feb;20(2):353-365. doi: 10.1111/jth.15554. Epub 2021 Oct 29. PMID: 34653316.
5. Sanrattana W, Sefiane T, Smits S, van Kleef ND, Fens MH, Lenting PJ, Maas C, de Maat S. A reactive center loop-based prediction platform to enhance the design of therapeutic SERPINs. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2108458118. doi: 10.1073/pnas.2108458118. PMID: 34740972; PMCID: PMC8609344.

Patents:

1. WO2020214033A1 Papain-like cysteine peptidase medicaments and uses thereof. - Mirjam Maaike Mebius, Aloysius Gerard Marie Tielens, Jaap Jan van Hellemond, Philip Gerrit de Groot, Rolf Theodoor Urbanus
2. WO2019185723A1 Targeted thrombolysis for treatment of microvascular thrombosis - Coen Maas, Steven de Maat
3. WO2018154044A1 Modified serpins for the treatment of bradykinin-mediated disease - Coen Maas, Steven de Maat

Facilities Involved uitklapper, klik om te openen

Minidonor dienst

People Involved uitklapper, klik om te openen

Idske Kremer Hovinga, Vossa van der Vegte, Tessa Noordermeer, Minka Zivkovic, Konrad Zwetsloot, Arjan Barendrecht, Simone Smits, Rowan Frunt, Hinde El Otmani,

dr. R.S. (Coen) Groenendal

Associate Professor

ir. drs. I. (Rolf) Popering

Associate Professor

drs. G. Butt

Full Professor

ir. drs. W.X. (Kathelijn) Bastiaan

Associate Professor - medical

C.D.D. (Geke) Bogerd BASc

PHD Candidate - OIO

Contact uitklapper, klik om te openen

Coen Maas, Rolf Urbanus