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drs. P.Q.Q. (Elly) Hegeman

drs. P.Q.Q. (Elly) Hegeman

Full Professor

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Research Output (184)

Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age

Hulshof Lianne A., Frajmund Leon A., van Nuijs Danny, van der Heijden Denise C.N., Middeldorp Jinte, Hol Elly M. May 2022, In: Neurobiology of Aging. 113 , p. 28-38 11 p.

The neurovascular unit in leukodystrophies:towards solving the puzzle

Zarekiani Parand, Nogueira Pinto Henrique, Hol Elly M, Bugiani Marianna, de Vries Helga E 28 Feb 2022, In: Fluids and barriers of the CNS. 19 , p. 1-19

Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors

Donega Vanessa, van der Geest Astrid T., Sluijs Jacqueline A., van Dijk Roland E., Wang Chi Chiu, Basak Onur, Pasterkamp R. Jeroen, Hol Elly M. 24 Feb 2022, In: Nature Communications. 13 , p. 1-12

GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence

Uceda-Castro Rebeca, van Asperen Jessy V., Vennin Claire, Sluijs Jacqueline A., van Bodegraven Emma J., Margarido Andreia S., Robe Pierre A.J., van Rheenen Jacco, Hol Elly M. 10 Jan 2022, In: Scientific Reports. 12 14 p.

Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice

Huffels Christiaan F.M., Osborn Lana M., Hulshof Lianne A., Kooijman Lieneke, Henning Lukas, Steinhäuser Christian, Hol Elly M. 2022, In: GLIA. 70 , p. 748-767 20 p.

Transcriptomic and functional analysis of Aβ1-42 oligomer-stimulated human monocyte-derived microglia-like cells

Smit Tamar, Ormel Paul R, Sluijs Jacqueline A, Hulshof Lianne A, Middeldorp Jinte, de Witte Lot D, Hol Elly M, Donega Vanessa 9 Dec 2021, In: Brain, Behavior, and Immunity. 100 , p. 219-230 12 p.

DNA methylation differences in cortical grey and white matter in schizophrenia

Berdenis Van Berlekom Amber, Notman Nina, Sneeboer Marjolein A.M., Snijders Gijsje J.L.J., Houtepen Lotte C., Nispeling Danny M., He Yujie, Dracheva Stella, Hol Elly M., Kahn René S., De Witte Lot D., Boks Marco P. 29 Jul 2021, In: Epigenomics. 13 , p. 1157-1169 13 p.

Mechanical alterations of the hippocampus in the APP/PS1 Alzheimer's disease mouse model

Antonovaite Nelda, Hulshof Lianne A, Huffels Christiaan F M, Hol Elly M, Wadman Wytse J, Iannuzzi Davide 10 Jul 2021, In: Journal of the mechanical behavior of biomedical materials. 122 , p. 1-9

New GFAP splice isoform (GFAPµ) differentially expressed in glioma translates into 21 kDa N-terminal GFAP protein

van Bodegraven Emma J., Sluijs Jacqueline A., Tan A. Katherine, Robe Pierre A.J.T., Hol Elly M. Mar 2021, In: FASEB Journal. 35 14 p.

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