drs. P.Q.Q. (Elly) Hegeman

drs. P.Q.Q. (Elly) Hegeman

Full Professor
drs. P.Q.Q. (Elly) Hegeman
  • Translational Neuroscience

Research Programs



Elly Hol is professor of “Glia biology of brain diseases” at the Utrecht University and a member of the Academia Europaea. She is head of the department of Translational Neuroscience at the University Medical Center Utrecht Brain Center. Her research is focused on the role of glial cells in brain diseases. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases. Elly was trained as a medical biologist with a specialization in molecular neurobiology. After her PhD in Utrecht, she obtained a Max-Planck Fellowship to work at the Max-Planck-Institute for Psychiatry in Martinsried. In 1997, she started as a post-doc at the Netherlands Institute for Neuroscience in Amsterdam, and between 2003 and 2013 she headed the group “Astrocyte Biology & Neurodegeneration”. She was appointed professor of "Biology of glia and neural stem cells” at the University of Amsterdam in 2012. As of 2013 she works as a principal investigator at the department of translational neuroscience, UMC Utrecht Brain Center. She is in the editorial board of Glia, chair of the scientific advisory board of Parkinson Nederland, chair of GliaNed, director of the Neuroscience Master and PhD program of the Utrecht University Graduate School of Life Sciences, and director of education Division Neuroscience at the UMCU.

Side Activities

Board member, Stichting vrienden van het Herseninstituut

Chair Scientific Advisory Board, Parkinson Nederland

Member Scientific Advisory Board, Alzheimer Nederland

Member Scientific advisory board EndParalysis Foundation

Member editorial board, Glia (scientific journal)

Fellowship and Awards

  • 2019 NWO Gravitation grant
  • 2019 member of the Academia Europaea
  • Nominated by NWO for AcademiaNet - Expert Database for Outstanding Female Scientists and Scholars.
  • 2009 VICI (NWO-ALW)
  • 2000 Hersenstichting fellowship
  • 1995 Max-Planck Fellowship

Research Output (184)

Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age

Hulshof Lianne A., Frajmund Leon A., van Nuijs Danny, van der Heijden Denise C.N., Middeldorp Jinte, Hol Elly M. May 2022, In: Neurobiology of Aging. 113 , p. 28-38 11 p.

The neurovascular unit in leukodystrophies:towards solving the puzzle

Zarekiani Parand, Nogueira Pinto Henrique, Hol Elly M, Bugiani Marianna, de Vries Helga E 28 Feb 2022, In: Fluids and barriers of the CNS. 19 , p. 1-19

Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors

Donega Vanessa, van der Geest Astrid T., Sluijs Jacqueline A., van Dijk Roland E., Wang Chi Chiu, Basak Onur, Pasterkamp R. Jeroen, Hol Elly M. 24 Feb 2022, In: Nature Communications. 13 , p. 1-12

GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence

Uceda-Castro Rebeca, van Asperen Jessy V., Vennin Claire, Sluijs Jacqueline A., van Bodegraven Emma J., Margarido Andreia S., Robe Pierre A.J., van Rheenen Jacco, Hol Elly M. 10 Jan 2022, In: Scientific Reports. 12 14 p.

Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice

Huffels Christiaan F.M., Osborn Lana M., Hulshof Lianne A., Kooijman Lieneke, Henning Lukas, Steinhäuser Christian, Hol Elly M. 2022, In: GLIA. 70 , p. 748-767 20 p.

Transcriptomic and functional analysis of Aβ1-42 oligomer-stimulated human monocyte-derived microglia-like cells

Smit Tamar, Ormel Paul R, Sluijs Jacqueline A, Hulshof Lianne A, Middeldorp Jinte, de Witte Lot D, Hol Elly M, Donega Vanessa 9 Dec 2021, In: Brain, Behavior, and Immunity. 100 , p. 219-230 12 p.

DNA methylation differences in cortical grey and white matter in schizophrenia

Berdenis Van Berlekom Amber, Notman Nina, Sneeboer Marjolein A.M., Snijders Gijsje J.L.J., Houtepen Lotte C., Nispeling Danny M., He Yujie, Dracheva Stella, Hol Elly M., Kahn René S., De Witte Lot D., Boks Marco P. 29 Jul 2021, In: Epigenomics. 13 , p. 1157-1169 13 p.

Mechanical alterations of the hippocampus in the APP/PS1 Alzheimer's disease mouse model

Antonovaite Nelda, Hulshof Lianne A, Huffels Christiaan F M, Hol Elly M, Wadman Wytse J, Iannuzzi Davide 10 Jul 2021, In: Journal of the mechanical behavior of biomedical materials. 122 , p. 1-9

New GFAP splice isoform (GFAPµ) differentially expressed in glioma translates into 21 kDa N-terminal GFAP protein

van Bodegraven Emma J., Sluijs Jacqueline A., Tan A. Katherine, Robe Pierre A.J.T., Hol Elly M. Mar 2021, In: FASEB Journal. 35 14 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet