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prof. dr. C.D.D. (Wouter) de Mackaaij

prof. dr. C.D.D. (Wouter) de Mackaaij

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Research Output (86)

Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation

Hall Amelia Weber, Chaffin Mark, Roselli Carolina, Lin Honghuang, Lubitz Steven A, Bianchi Valerio, Geeven Geert, Bedi Kenneth, Margulies Kenneth B, de Laat Wouter, Tucker Nathan R, Ellinor Patrick T 2020, In: Circulation. Genomic and precision medicine. 13 , p. 588-598 11 p.

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

Man Joyce C.K., Mohan Rajiv A., Boogaard Malou van den, Hilvering Catharina R.E., Jenkins Catherine, Wakker Vincent, Bianchi Valerio, Laat Wouter de, Barnett Phil, Boukens Bastiaan J., Christoffels Vincent M. 1 Dec 2019, In: Nature Communications. 10 15 p.

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation

van den Boogaard Malou, van Weerd Jan Hendrik, Bawazeer Amira C, Hooijkaas Ingeborg B, van de Werken Harmen J G, Tessadori Federico, de Laat Wouter, Barnett Phil, Bakkers Jeroen, Christoffels Vincent M 3 Sep 2019, In: Cell Reports. 28 , p. 2704-2714.e5

4C-seq from beginning to end:A detailed protocol for sample preparation and data analysis

Krijger Peter H L, Geeven Geert, Bianchi Valerio, Hilvering Catharina R E, de Laat Wouter 26 Jul 2019, In: Methods. 170 , p. 17-32 16 p.

Noncoding deletions reveal a gene that is critical for intestinal function

Oz-Levi Danit, Olender Tsviya, Bar-Joseph Ifat, Zhu Yiwen, Marek-Yagel Dina, Barozzi Iros, Osterwalder Marco, Alkelai Anna, Ruzzo Elizabeth K, Han Yujun, Vos Erica S M, Reznik-Wolf Haike, Hartman Corina, Shamir Raanan, Weiss Batia, Shapiro Rivka, Pode-Shakked Ben, Tatarskyy Pavlo, Milgrom Roni, Schvimer Michael, Barshack Iris, Imai Denise M, Coleman-Derr Devin, Dickel Diane E, Nord Alex S, Afzal Veena, van Bueren Kelly Lammerts, Barnes Ralston M, Black Brian L, Mayhew Christopher N, Kuhar Matthew F, Pitstick Amy, Tekman Mehmet, Stanescu Horia C, Wells James M, Kleta Robert, de Laat Wouter, Goldstein David B, Pras Elon, Visel Axel, Lancet Doron, Anikster Yair, Pennacchio Len A Jul 2019, In: Nature. 571 , p. 107-111 5 p.

DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

Redolfi Josef, Zhan Yinxiu, Valdes-Quezada Christian, Kryzhanovska Mariya, Guerreiro Isabel, Iesmantavicius Vytautas, Pollex Tim, Grand Ralph S, Mulugeta Eskeatnaf, Kind Jop, Tiana Guido, Smallwood Sebastien A, de Laat Wouter, Giorgetti Luca Jun 2019, In: Nature Structural and Molecular Biology. 26 , p. 471-480 10 p.

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes

Laarman Melanie D., Geeven Geert, Barnett Phil, Rinkel Gabriël J.E., de Laat Wouter, Ruigrok Ynte M., Bakkers Jeroen, 7 May 2019, In: Journal of the American Heart Association. 8

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo

Monroe Tanner O., Hill Matthew C., Morikawa Yuka, Leach John P., Heallen Todd, Cao Shuyi, Krijger Peter H.L., de Laat Wouter, Wehrens Xander H.T., Rodney George G., Martin James F. 25 Mar 2019, In: Developmental Cell. 48 , p. 765-779.e7

Enhancer hubs and loop collisions identified from single-allele topologies

Allahyar Amin, Vermeulen Carlo, Bouwman Britta A.M., Krijger Peter H.L., Verstegen Marjon J.A.M., Geeven Geert, van Kranenburg Melissa, Pieterse Mark, Straver Roy, Haarhuis Judith H.I., Jalink Kees, Teunissen Hans, Renkens Ivo J., Kloosterman Wigard P., Rowland Benjamin D., de Wit Elzo, de Ridder Jeroen, de Laat Wouter 1 Aug 2018, In: Nature Genetics. 50 , p. 1151-1160 10 p.

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression

Gupta Rajat M., Hadaya Joseph, Trehan Aditi, Zekavat Seyedeh M., Roselli Carolina, Klarin Derek, Emdin Connor A., Hilvering Catharina R.E., Bianchi Valerio, Mueller Christian, Khera Amit V., Ryan Russell J.H., Engreitz Jesse M., Issner Robbyn, Shoresh Noam, Epstein Charles B., de Laat Wouter, Brown Jonathan D., Schnabel Renate B., Bernstein Bradley E., Kathiresan Sekar 27 Jul 2017, In: Cell. 170 , p. 522-533.e15

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