prof. dr. C.D.D. (Wouter) de Mackaaij
prof. dr. C.D.D. (Wouter) de Mackaaij
- Group Burgering, section Molecular Cancer Research
- Department of Genetics
- Hubrecht Institute
Research Programs
Biography
Biography
Wouter de Laat studied biology at the Utrecht University. During his PhD (1998) at the Erasmus University Rotterdam (Prof. Jan Hoeijmakers) he investigated the molecular mechanism of nucleotide excision repair. He identified one of the nucleases and characterized the interplay between repair factors at the site of the lesion. As a postdoc, he joined the group of Prof. Frank Grosveld to work on beta-globin gene activation. In 2000 he received a career grant (VIDI) to work on long-range gene activation. His group used 3C technology, and later developed 4C technology, to demonstrate chromatin loops between genes and enhancers and to uncover long-range DNA contacts within and between chromosomes.
In 2008 he received an ERC Young Investigator Grant. In September 2008 de Laat moved his group to the Hubrecht Institute, where he continued his work on genome structure and function. In January 2009 he was appointed professor in Biomedical Genomics at the University Medical Center Utrecht. He received a prestigious VICI career grant in 2012.
Side Activities
- Mentor UAF, Universitair Asielfonds
- Founder of Cergentis. Cergentis was acquired by Solvias in 2022. Wouter de Laat no longer has financial interest/role in Cergentis.
- Scientific Editor Frontiers in Cell and Developmental Biology
- Scientific Advisory Board Max Planck Institute for Molecular Genetics Berlin
Fellowship and Awards
VIDI (2000)
VICI (2012)
ERC Starting Grant (2008)
EMBO Member
Research Output (86)
Allahyar Amin, Pieterse Mark, Swennenhuis Joost, Los-de Vries G. Tjitske, Yilmaz Mehmet, Leguit Roos, Meijers Ruud W.J., van der Geize Robert, Vermaat Joost, Cleven Arjen, van Wezel Tom, Diepstra Arjan, van Kempen Léon C., Hijmering Nathalie J., Stathi Phylicia, Sharma Milan, Melquiond Adrien S.J., de Vree Paula J.P., Verstegen Marjon J.A.M., Krijger Peter H.L., Hajo Karima, Simonis Marieke, Rakszewska Agata, van Min Max, de Jong Daphne, Ylstra Bauke, Feitsma Harma, Splinter Erik, de Laat Wouter Dec 2021, In: Nature Communications. 12 , p. 1-15
Krijger Peter H.L., Hoek Tim A., Boersma Sanne, Donders Lieke I.P.M., Broeders Maaike M.C., Pieterse Mark, Toonen Pim W., Logister Ive, Verhagen Bram M.P., Verstegen Marjon J.A.M., van Ravesteyn Thomas W., Roymans Rene J.T.M., Mattiroli Francesca, Vandesompele Jo, Nijhuis Monique, Meijer Stefan, van Weert Anton, Dekker Edwin, Dom Fred J., Ruijtenbeek Rob, van der Velden Lieven B.J., van de Bovenkamp Jeroen H.B., Bosch Martijn, de Laat Wouter, Tanenbaum Marvin E. Oct 2021, In: Nature Biotechnology. 39 , p. 1182-1184 3 p.
Vos Erica S.M., Valdes-Quezada Christian, Huang Yike, Allahyar Amin, Verstegen Marjon J.A.M., Felder Anna Karina, van der Vegt Floor, Uijttewaal Esther C.H., Krijger Peter H.L., de Laat Wouter 5 Aug 2021, In: Molecular Cell. 81 , p. 3082-3095.e6
Tjalsma Sjoerd Jd, de Laat Wouter Apr 2021, In: Current Opinion in Genetics & Development. 67 , p. 10-17 8 p.
Huang Yike, Neijts Roel, de Laat Wouter Nov 2020, In: FEBS letters. 594 , p. 3439-3449 11 p.
Man Joyce Ck, van Duijvenboden Karel, Krijger Peter Hl, Hooijkaas Ingeborg B, van der Made Ingeborg, de Gier-de Vries Corrie, Wakker Vincent, Creemers Esther E, de Laat Wouter, Boukens Bastiaan J, Christoffels Vincent M 27 Oct 2020, In: Circulation research. 128 , p. 115-129 15 p.
Castelijns Bas, Baak Mirna L, Geeven Geert, Vermunt Marit W, Wiggers Caroline R M, Timpanaro Ilia S, Kondova Ivanela, de Laat Wouter, Creyghton Menno P 23 Jun 2020, In: Cell Reports. 31 , p. 1-18
van Ouwerkerk Antoinette F, Hall Amelia W, Kadow Zachary A, Lazarevic Sonja, Reyat Jasmeet S, Tucker Nathan R, Nadadur Rangarajan D, Bosada Fernanda M, Bianchi Valerio, Ellinor Patrick T, Fabritz Larissa, Martin James F, de Laat Wouter, Kirchhof Paulus, Moskowitz Ivan P, Christoffels Vincent M 19 Jun 2020, In: Circulation research. 127 , p. 34-50 17 p.
Vermeulen Carlo, Allahyar Amin, Bouwman Britta A.M., Krijger Peter H.L., Verstegen Marjon J.A.M., Geeven Geert, Valdes-Quezada Christian, Renkens Ivo, Straver Roy, Kloosterman Wigard P., de Ridder Jeroen, de Laat Wouter 1 Feb 2020, In: Nature Protocols. 15 , p. 364-397 34 p.
Castelijns Bas, Baak Mirna L., Timpanaro Ilia S., Wiggers Caroline R.M., Vermunt Marit W., Shang Peng, Kondova Ivanela, Geeven Geert, Bianchi Valerio, de Laat Wouter, Geijsen Niels, Creyghton Menno P. 16 Jan 2020, In: Nature Communications. 11 12 p.