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dr. P.Q.Q. (Judith) Smissen

dr. P.Q.Q. (Judith) Smissen

Full Professor

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Research Output (161)

Author Correction: Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions

Jonker Caspar T H, Galmes Romain, Veenendaal Tineke, Ten Brink Corlinda, van der Welle Reini E N, Liv Nalan, de Rooij Johan, Peden Andrew A, van der Sluijs Peter, Margadant Coert, Klumperman Judith Dec 2021, In: Nature Communications. 12 , p. 1-1

ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability

Özkan Nazmiye, Koppers Max, van Soest Inge, van Harten Alexandra, Jurriens Daphne, Liv Nalan, Klumperman Judith, Kapitein Lukas C, Hoogenraad Casper C, Farías Ginny G Dec 2021, In: Nature Communications. 12 , p. 1-18

Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide

Gao Xinxin, Mazière Ann De, Beard Rhiannon, Klumperman Judith, Hannoush Rami N 19 Nov 2021, In: iScience. 24 , p. 1-17

Erratum: DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells

van Rijn Jorik M, van Hoesel Marliek, de Heus Cecilia, van Vugt Anke H M, Klumperman Judith, Nieuwenhuis Edward E S, Houwen Roderick H J, Middendorp Sabine 6 Oct 2021, In: Journal of Lipid Research. 62 , p. 1-1

The stress-sensing domain of activated IRE1 alpha forms helical filaments in narrow ER membrane tubes

Tran Ngoc-Han, Carter Stephen D, De Mazière Ann, Ashkenazi Avi, Klumperman Judith, Walter Peter, Jensen Grant J 1 Oct 2021, In: Science. 374 , p. 52-57 6 p.

Understanding membrane traffic from molecular ensemble, energetics, and the cell biology of participant components

Klumperman Judith, Pucadyil Thomas Aug 2021, In: Current Opinion in Cell Biology. 71 , p. iii-vi

A-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

Dilsizoglu Senol Aysegul, Samarani Maura, Syan Sylvie, Guardia Carlos M, Nonaka Takashi, Liv Nalan, Latour-Lambert Patricia, Hasegawa Masato, Klumperman Judith, Bonifacino Juan S, Zurzolo Chiara Jul 2021, In: PLoS Biology. 19 , p. 1-49

Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

Jamalpoor Amer, van Gelder Charlotte Agh, Yousef Yengej Fjodor A, Zaal Esther A, Berlingerio Sante P, Veys Koenraad R, Pou Casellas Carla, Voskuil Koen, Essa Khaled, Ammerlaan Carola Me, Rega Laura Rita, van der Welle Reini En, Lilien Marc R, Rookmaaker Maarten B, Clevers Hans, Klumperman Judith, Levtchenko Elena, Berkers Celia R, Verhaar Marianne C, Altelaar Maarten, Masereeuw Rosalinde, Janssen Manoe J 24 Jun 2021, In: Embo Molecular Medicine. 13 , p. 1-20

Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation

van der Welle Reini E N, Jobling Rebekah, Burns Christian, Sanza Paolo, van der Beek Jan A, Fasano Alfonso, Chen Lan, Zwartkruis Fried J, Zwakenberg Susan, Griffin Edward F, Ten Brink Corlinda, Veenendaal Tineke, Liv Nalan, van Ravenswaaij-Arts Conny M A, Lemmink Henny H, Pfundt Rolph, Blaser Susan, Sepulveda Carolina, Lozano Andres M, Yoon Grace, Santiago-Sim Teresa, Asensio Cedric S, Caldwell Guy A, Caldwell Kim A, Chitayat David, Klumperman Judith 14 Apr 2021, In: Embo Molecular Medicine. 13 24 p.

Pancreatic beta-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion

Burns Christian H, Yau Belinda, Rodriguez Anjelica, Triplett Jenna, Maslar Drew, An You Sun, van der Welle Reini E N, Kossina Ross G, Fisher Max R, Strout Gregory W, Bayguinov Peter O, Veenendaal Tineke, Chitayat David, Fitzpatrick James A J, Klumperman Judith, Kebede Melkam A, Asensio Cedric S 1 Feb 2021, In: Diabetes. 70 , p. 436-448 13 p.

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