dr. P.Q.Q. (Judith) Smissen
dr. P.Q.Q. (Judith) Smissen
- Cell Biology
Research Programs
Biography
Biography
Since 2001 Judith Klumperman is professor of Cell Biology and since 2008 chair of the Department of Cell Biology at the UMC Utrecht. She is also head of the Cell Microscopy Core of the UMC Utrecht, which is widely recognized as one of the best expertise centers in the world for immuno-electron microscopy. On a yearly basis the UMC Utrechts trains and assist over 40 scientists from the Netherlands and 15-20 international guests.She is often asked for expert microscopy advise and participate(d) in a large number of international collaborations.
Her research focus on understanding the molecular basis of human diseases, with an emphasis on diseases of the endo-lysosomal system. Diseases specifically addressed in my work are: Lysosomal storage disorders (Pompe disease; Mucolipidosis II/I-Cell disease) – Alzheimer disease – Hermansky Pudlak Syndrome (pigmentation bleeding disorder) - Cancer – virus and bacterial infections – ARC syndrome –Microvillar inclusion Disease. In addition, her work has elucidated fundamental concepts of endosome and lysosome biogenesis, of which the most recent finding is a novel pathway for the delivery of lysosomal membrane proteins to the lysosomes.
Side Activities
Regular (>10) member or chair of Appointment Advisory Committee’s (Benoemings Advies Commissies) for new professors (Utrecht, Nijmegen, Wageningen and Groningen University
Regular (>20) member of chair of thesis assessment committee’s (Universities of Utrecht, Leiden, Rotterdam, Amsterdam, Nijmegen, Leuven (Belgium), Copenhagen (Denmark)).
ESFRI initiative EuroBioImaging. 2010-2014: Steering Committee (member). 2009-2014: WP4: Coordinator for Correlative Light Electron Microscopy.
Utrecht Graduate School Institute of Biomembranes, (interim project leader, Board Member, Chair) 2000-2010
Netherlands Society for Microscopy (NVvM) Board member, Vice president 2001-2007
Member project management team NL-BioImaging-AM, the Dutch Research Infrastructure for Advanced Microscopy. 2001-2007
Royal Dutch Academy of Arts and Sciences (KNAW). Financing Biomedical Research and Council for Medical Sciences and Royal Dutch Academy of Arts and Sciences (KNAW). Chair exploratory committee ‘Tissue Engineering’ 2002-2011
committee NWO medium-sized investment grants and Big Investments 2001-2015
University Utrecht delegation to improve contact with Chinese universities 2006
Regional committee Asia, University of Utrecht 2006-2010
ZON-MW (Medical Research Netherlands – Medical Sciences) -committee medium-sized (<9k€) investment grants. Member and Vice-chair 2005-2009
Utrecht PhD program ‘Biomembranes’. 2004-2006: Board member. 2007-2010: Chair. 2010 – present: Board member
Member committee ‘Internationalisering II’. UMC Utrecht 2008-2011
Chair committee Electron microscopy University Utrecht 2011
Coordinator CLEM workpackage ESFRI infrastructure EuroBioimaging 2009-2015
Member user committees STW (foundation for technical sciences) in projects of Meijering (Erasmus MC), Gerritsen (UU), Giepmans (UMC Groningen) and Koster (Leiden UMC) 2012-2018
Member international review panel Cell Biology and Biophysics Unit European Molecular Biology Laboratory (EMBL), Heidelberg, Germany 2013
Chair ad hoc committee scientific integrity, installed by B. vd Zwaan, rector University Utrecht 2013-2014
vice-National Contact person (NCP) for the Netherlands in EuroBioImaging 2009-2015
Member project management team NL-BioImaging-AM, the Dutch Research Infrastructure for Advanced Microscopy. 2001-1015
NL-BioImaging-AM. Dutch Roadmap initiative for Research Infrastructure for Advanced Microscopy. 2011-present: Vice-chair of the Project Management Team
Dutch Technology Centre (DTL).2011-present: Member of the Core group
Associate editor: Molecular Biology of the Cell. Editorial boards: Traffic, Histochemistry and Cell Biology, Biology of the Cell, PeerJ. Section editor: Current Opinion in Cell Biology. Member of FACULTY F1000
Cell Microscopy Centre (CMC), UMC Utrecht, Chair (2009-2018)
Steering Committee EM Square, Utrecht University (2015 - present)
Netherlands Electron Microscopy Infrastructure (NEMI) Chair Executive Board (2015 - present)
Center for Molecular Medicine (CMM) UMC Utrecht, member management team (2018 - present)
Editorships
Traffic, Histochemistry and Cell Biology, Biology of the Cell, Current Opinion in Cell Biology (Section editor of the Membranes and organelles issue in 2004 and 2021), Molecular Biology of the Cell (associate editor till 2018), PeerJ (Open access journal of The Royal Society)
August 2021: Guest editor Current Opinion in Cell Biology
Reviewer: Cell, Nature, Journal of Cell Biology, EMBO Journal, Nature Cell Biology, Nature Communications, Cell Reports, Molecular Biology of the Cell, Journal of Cell Science, Traffic, Histochemistry & Cell Biology.
Grant reviewer: Dutch Society for Scientific research (NWO), Wellcome Trust (UK), Medical Research Council (UK), Telethon (Italy), KNAW, Koningin Wilhelmina Fonds (KWF), EMBO
Fellowship and Awards
2007: 20th Foundation lecture, Center for Cell and Molecular Biology, Hyderabad, India.
2004: VICI Award (1.25M€) from the Netherlands Organisation for Scientific Research.
1998: UMC Utrecht award: Attraction and maintenance of female talent.
Research Output (161)
Jonker Caspar T H, Galmes Romain, Veenendaal Tineke, Ten Brink Corlinda, van der Welle Reini E N, Liv Nalan, de Rooij Johan, Peden Andrew A, van der Sluijs Peter, Margadant Coert, Klumperman Judith Dec 2021, In: Nature Communications. 12 , p. 1-1
Özkan Nazmiye, Koppers Max, van Soest Inge, van Harten Alexandra, Jurriens Daphne, Liv Nalan, Klumperman Judith, Kapitein Lukas C, Hoogenraad Casper C, Farías Ginny G Dec 2021, In: Nature Communications. 12 , p. 1-18
Gao Xinxin, Mazière Ann De, Beard Rhiannon, Klumperman Judith, Hannoush Rami N 19 Nov 2021, In: iScience. 24 , p. 1-17
van Rijn Jorik M, van Hoesel Marliek, de Heus Cecilia, van Vugt Anke H M, Klumperman Judith, Nieuwenhuis Edward E S, Houwen Roderick H J, Middendorp Sabine 6 Oct 2021, In: Journal of Lipid Research. 62 , p. 1-1
Tran Ngoc-Han, Carter Stephen D, De Mazière Ann, Ashkenazi Avi, Klumperman Judith, Walter Peter, Jensen Grant J 1 Oct 2021, In: Science. 374 , p. 52-57 6 p.
Klumperman Judith, Pucadyil Thomas Aug 2021, In: Current Opinion in Cell Biology. 71 , p. iii-vi
Dilsizoglu Senol Aysegul, Samarani Maura, Syan Sylvie, Guardia Carlos M, Nonaka Takashi, Liv Nalan, Latour-Lambert Patricia, Hasegawa Masato, Klumperman Judith, Bonifacino Juan S, Zurzolo Chiara Jul 2021, In: PLoS Biology. 19 , p. 1-49
Jamalpoor Amer, van Gelder Charlotte Agh, Yousef Yengej Fjodor A, Zaal Esther A, Berlingerio Sante P, Veys Koenraad R, Pou Casellas Carla, Voskuil Koen, Essa Khaled, Ammerlaan Carola Me, Rega Laura Rita, van der Welle Reini En, Lilien Marc R, Rookmaaker Maarten B, Clevers Hans, Klumperman Judith, Levtchenko Elena, Berkers Celia R, Verhaar Marianne C, Altelaar Maarten, Masereeuw Rosalinde, Janssen Manoe J 24 Jun 2021, In: Embo Molecular Medicine. 13 , p. 1-20
van der Welle Reini E N, Jobling Rebekah, Burns Christian, Sanza Paolo, van der Beek Jan A, Fasano Alfonso, Chen Lan, Zwartkruis Fried J, Zwakenberg Susan, Griffin Edward F, Ten Brink Corlinda, Veenendaal Tineke, Liv Nalan, van Ravenswaaij-Arts Conny M A, Lemmink Henny H, Pfundt Rolph, Blaser Susan, Sepulveda Carolina, Lozano Andres M, Yoon Grace, Santiago-Sim Teresa, Asensio Cedric S, Caldwell Guy A, Caldwell Kim A, Chitayat David, Klumperman Judith 14 Apr 2021, In: Embo Molecular Medicine. 13 24 p.
Burns Christian H, Yau Belinda, Rodriguez Anjelica, Triplett Jenna, Maslar Drew, An You Sun, van der Welle Reini E N, Kossina Ross G, Fisher Max R, Strout Gregory W, Bayguinov Peter O, Veenendaal Tineke, Chitayat David, Fitzpatrick James A J, Klumperman Judith, Kebede Melkam A, Asensio Cedric S 1 Feb 2021, In: Diabetes. 70 , p. 436-448 13 p.