prof. C.D.D. (Paul) Mager

prof. C.D.D. (Paul) Mager

Full Professor
prof. C.D.D. (Paul) Mager
  • Stem Cells
  • Onderzoek



Paul Coffer studied Biochemistry at Oxford University and obtained his PhD from the Ludwig Institute for Cancer Research in London, UK where he identified Protein Kinase B (PKB/AKT), a critical intracellular hub regulating multiple cellular processes.

He then relocated to the Hubrecht Laboratory for Developmental Biology and Stem Cell Research. This postdoctoral research was involved in investigating the mechanisms by which hematopoietic cytokines can regulate gene expression through transcription factor phosphorylation.

Paul moved to the Department of Respiratory Medicine at the University Medical Centre Utrecht to initiate his own research group. During this period, work involved studying the role of intracellular signal transduction pathways in regulating both the production and function of leukocytes. Work in his group also demonstrated that PKB-mediated phosphorylation of Forkhead transcription factors (FOXO) was critical for the regulation of leukocyte proliferation and survival. These studies laid the groundwork for his further research into the regulation of hematopoietic stem cell-fate decisions.

In 2005 Paul Coffer was appointed Professor of Pediatric Immunology moving to the Wilhelmina Children's Hospital (UMCU). During this time research was expanded to investigate the molecular mechanisms regulating mesenchymal stem stem cell (MSC) function and generation of induced pluripotent stem cells (iPSC) as models of disease. Furthermore, studies investigating the molecular mechanisms underlying T-regulatory cell function were initiated.

In 2010 he moved to the UMC Utrecht Center for Molecular Medicine (CMM) and  in 2013 worked at  Memorial Sloan-Kettering Cancer Center (New York) for 14 months in Sasha Rudensky's Lab. 

Current research is driven by both fundamental and clinical questions inersecting the fuelds of tumor biology and immunology. This is focussed on identifying pathways that can be exploited to selectively target cells in both cancer and (auto)immunity. This translational research applies a broad range of state-of-the-art molecular and cell biologival appraoches as well as in vivo and ex-vivo models of disease.


Side Activities

2019-  Board of trustees, World Wide Cancer Research

2016-Study Section member for both Fundamental and Translational applications for the Dutch Rheumatology Foundation (ReumaFonds; around 100 grant applications per year)

2016/2018 Study section member for the Swedish Research Council (SRC), consolidator grants for established investigators.

2016 Study section member for National Institutes of Health (NIH/NIAD), Immunology review branch.

2016 Advisory panel member and site visit for quinquennial review of Molecular Mechanisms of Disease Master’s program, Radboud University (Nijmegen, The Netherlands)

2014- Hubrecht Institute selection committee for new junior and senior principle investigators

2013-2018 Study section member for the Worldwide Cancer Research (WWCR/AICR; more than 800 international grant applications submitted each year)

2011/2014 Scientific Advisory Board Member and site visit, ViB Institute of Inflammation & Immunity (Ghent, Belgium).

2008- Committee member Dutch Society for Stem Cell Research (DSSCR) and chair 2010 & 2015

2011-2012 Study section member for Netherlands Organization for Scientific Research (NWO) collaborative TOP grants for senior PIs and largest national project grant applications

2008 Site visit for Leukemia Research Foundation UK (Immunodiagnostics Unit, John Radcliff Hospital, Oxford)

2007 Study section member Portugese Foundation of Science & Technology (FCT)

2005-  Section Editor, Journal of Leukocyte Biology

Regular reviewer for journals: Nature, Science, Science Immunology, Nature Cell Biology, Nature Immunology, Nature Communications, Immunity, Journal of Clinical Investigation, Journal of Experimental Medicine, EMBO Journal, Blood, Oncogene, Molecular Cell Biology, Journal of Biological Chemistry, Journal of Immunology.


Ad hoc reviewer of grants for: National Institutes of Health (NIH), Dutch Scientific Organisation (NWO), Dutch Cancer Foundation (KWF), Swedish Research Council (SRC); Cancer Research UK (CRUK), Wellcome Trust UK, BBRC UK, Leukemia Research Foundation (LRF), Swiss National Science Foundation (SNF), Portugese Foundation of Science & Technology (FCT).

Research Output (182)

Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation

Roukens M Guy, Frederiks Cynthia L, Seinstra Danielle, Braccioli Luca, Khalil Antoine A, Pals Cornelieke, De Neck Simon, Bornes Laura, Beerling Evelyne, Mokry Michal, de Bruin Alain, Westendorp Bart, van Rheenen Jacco, Coffer Paul J 2021, In: Oncogene. 40 , p. 6343-6353 11 p.

C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition

Lourenço Ana Rita, Roukens M. Guy, Seinstra Danielle, Frederiks Cynthia L., Pals Cornelieke E., Vervoort Stephin J., Margarido Andreia S., van Rheenen Jacco, Coffer Paul J. 7 Feb 2020, In: Nature Communications. 11 , p. 1-18

Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development

Govers Anita M A P, Wiggers Caroline R M, van Boxtel Ruben, Mokry Michal, Nieuwenhuis Edward E S, Creyghton Menno P, Bartels Marije, Coffer Paul J Aug 2019, In: HemaSphere. 3

Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia

Wiggers Caroline R M, Govers Anita M A P, Lelieveld Daphne, Egan David A, Zwaan C Michel, Sonneveld Edwin, Coffer Paul J, Bartels Marije 1 May 2019, In: Pediatric Blood & Cancer. 66

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Fleskens Veerle, Minutti Carlos M., Wu Xingmei, Wei Ping, Pals Cornelieke E.G.M., McCrae James, Hemmers Saskia, Groenewold Vincent, Vos Harm Jan, Rudensky Alexander, Pan Fan, Li Huabin, Zaiss Dietmar M., Coffer Paul J. 26 Mar 2019, In: Cell Reports. 26 , p. 3600-3612.e6

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

Vervoort Stephin J., de Jong Olivier G., Guy Roukens M., Frederiks Cynthia L., Vermeulen Jeroen F., Lourenço Ana Rita, Bella Laura, Vidakovic Ana Tufegdzic, Sandoval José L., Moelans Cathy, van Amersfoort Miranda, Dallman Margaret J., Bruna Alejandra, Caldas Carlos, Nieuwenhuis Edward, van der Wall Elsken, Derksen Patrick, van Diest Paul, Verhaar Marianne C., Lam Eric W.F., Mokry Michal, Coffer Paul J. 3 Dec 2018, In: eLife. 7

SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression

Braccioli Luca, Vervoort Stephin J., Puma Gianmarco, Nijboer Cora H., Coffer Paul J. 1 Dec 2018, In: Stem Cell Research. 33 , p. 110-119 10 p.

The role of WNT signaling in mature T cells:T cell factor is coming home

Van Loosdregt Jorg, Coffer Paul J. 15 Oct 2018, In: Journal of Immunology. 201 , p. 2193-2200 8 p.

SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis

Vervoort Stephin J., Lourenço Ana Rita, Tufegdzic Vidakovic Ana, Mocholi Enric, Sandoval José L., Rueda Oscar M., Frederiks Cynthia, Pals Cornelieke, Peeters Janneke G.C., Caldas Carlos, Bruna Alejandra, Coffer Paul J. 12 Oct 2018, In: Nucleic Acids Research. 46 , p. 9578-9590 13 p.

PD-1<sup>+</sup>CD8<sup>+</sup> T cells are clonally expanding effectors in human chronic inflammation

Petrelli Alessandra, Mijnheer Gerdien, Hoytema Van Konijnenburg David P., Van Der Wal Maria M., Giovannone Barbara, Mocholi Enric, Vazirpanah Nadia, Broen Jasper C., Hijnen Dirkjan, Oldenburg Bas, Coffer Paul J., Vastert Sebastian J., Prakken Berent J., Spierings Eric, Pandit Aridaman, Mokry Michal, Van Wijk Femke 1 Oct 2018, In: Journal of Clinical Investigation. 128 , p. 4669-4681 13 p.

All research output

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