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drs. F.G. (Floriaan) Leuken

drs. F.G. (Floriaan) Leuken

Associate Professor

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Research Output (43)

Mendelian randomization for studying the effects of perturbing drug targets [version 2; peer review: 3 approved, 1 approved with reservations]

Gill Dipender, Georgakis Marios K., Walker Venexia M., Schmidt A. Floriaan, Gkatzionis Apostolos, Freitag Daniel F., Finan Chris, Hingorani Aroon D., Howson Joanna M.M., Burgess Stephen, Swerdlow Daniel I., Davey Smith George, Holmes Michael V., Dichgans Martin, Scott Robert A., Zheng Jie, Psaty Bruce M., Davies Neil M. 2021, In: Wellcome Open Research. 6 , p. 1-19 19 p.

Mendelian randomization for studying the effects of perturbing drug targets [version 1; peer review:awaiting peer review]

Gill Dipender, Georgakis Marios K., Walker Venexia M., Schmidt A. Floriaan, Gkatzionis Apostolos, Freitag Daniel F., Finan Chris, Hingorani Aroon D., Howson Joanna M.M., Burgess Stephen, Swerdlow Daniel I., Smith George Davey, Holmes Michael V., Dichgans Martin, Zheng Jie, Psaty Bruce M., Davies Neil M. 2021, In: Wellcome Open Research. 6 , p. 1-11 11 p.

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease

Schmidt Amand F., Carter John Paul L., Pearce Lucy S., Wilkins John T., Overington John P., Hingorani Aroon D., Casas J. P. 20 Oct 2020, In: The Cochrane database of systematic reviews. 10 , p. 1-87

Association between 8 P-glycoprotein (MDR1/ABCB1) gene polymorphisms and antipsychotic drug-induced hyperprolactinaemia

Geers Lisanne M., Pozhidaev Ivan V., Ivanova Svetlana A., Freidin Maxim B., Schmidt Amand F., Cohen Dan, Boiko Anastasiia S., Paderina Diana Z., Fedorenko Olga Yu, Semke Arkadiy V., Bokhan Nikolay A., Wilffert Bob, Kosterink Jos G.W., Touw Daan J., Loonen Anton J.M. 1 Sep 2020, In: British Journal of Clinical Pharmacology. 86 , p. 1827-1835 9 p.

Genetic drug target validation using Mendelian randomisation

Schmidt Amand F, Finan Chris, Gordillo-Marañón Maria, Asselbergs Folkert W, Freitag Daniel F, Patel Riyaz S, Tyl Benoît, Chopade Sandesh, Faraway Rupert, Zwierzyna Magdalena, Hingorani Aroon D 26 Jun 2020, In: Nature Communications. 11 , p. 1-12

Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases

Howe Laurence J, Dudbridge Frank, Schmidt Amand F, Finan Chris, Denaxas Spiros, Asselbergs Folkert W, Hingorani Aroon D, Patel Riyaz S 28 May 2020, In: Human molecular genetics. 29 , p. 1388-1395 8 p.

Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke:Individual Participant Data Meta-Analysis in Up to 16 126 Participants

Borges Maria Carolina, Schmidt Amand Floriaan, Jefferis Barbara, Wannamethee S. Goya, Lawlor Debbie A., Kivimaki Mika, Kumari Meena, Gaunt Tom R., Ben-Shlomo Yoav, Tillin Therese, Menon Usha, Providencia Rui, Dale Caroline, Gentry-Maharaj Aleksandra, Hughes Alun, Chaturvedi Nish, Casas Juan Pablo, Hingorani Aroon D., 3 Mar 2020, In: Journal of the American Heart Association. 9 , p. e013131 26 p.

Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients

Losenkov Innokentiy S., Mulder Nathaniël J.V., Levchuk Lyudmila A., Vyalova Natalya M., Loonen Anton J.M., Bosker Fokko J., Simutkin German G., Boiko Anastasiia S., Bokhan Nikolay A., Wilffert Bob, Hak Eelko, Schmidt Amand F., Ivanova Svetlana A. 12 Feb 2020, In: Frontiers in Psychiatry. 11 , p. 1-8

Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke:A prospective analysis in 11,560 adults

Joshi Roshni, Wannamethee S. Goya, Engmann Jorgen, Gaunt Tom, Lawlor Deborah A., Price Jackie, Papacosta Olia, Shah Tina, Tillin Therese, Chaturvedi Nishi, Kivimaki Mika, Kuh Diana, Kumari Meena, Hughes Alun D., Casas Juan P., Humphries Steve, Hingorani Aroon D., Schmidt A. Floriaan 29 Jan 2020, In: European Journal of Preventive Cardiology. 27 , p. 1617-1626 10 p.

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