drs. F.G. (Floriaan) Leuken

drs. F.G. (Floriaan) Leuken

Associate Professor
drs. F.G. (Floriaan) Leuken
  • Onderzoek Precision medicine



A. Floriaan Schmidt has received training in public health, clinical epidemiology, and mathematics. Floriaan completed a PhD on methods for personalized medicine with the Utrecht University in the Netherlands. Following his PhD, he accepted a position with University College London (UCL). Currently, Floriaan has a joined position with UMC Utrecht and UCL. His research focusses on developing and applying human genetics for drug target validation (Schmidt, Nature Communications 2020 & 2021). Additionally, Floriaan conducts research to improve risk prediction modelling for patient subgroups by integrating electronic healthcare records data with information from multi-model sources including genomics and metabolomics. Floriaan has received funding from the British Heart Foundation, the National Institute for Health Research University College London Hospitals Biomedical Research Centre, Servier, IMI, and Erasmus+.

Side Activities

  1. Senior research fellow with the institute of cardiovascular science at University College London,
  2. Associate editor with Frontiers in Epidemiology. 

Fellowship and Awards


  • IMI BigData@Heart internal grant. Machine learning for Genetically guided drug discovery. For 96,150 euro.
  • IMI BigData@Heart internal grant. Describing and evaluating treatment and disease trajectories in cardiovascular disease. For 96,150 euro.
  • Erasmus+ dataclinic project to develop a European machine learning and engineering curriculum for healthcare professionals. For 400,000 euro.
  • Servier grant on Integrative bioinformatics for drug target validation. For 70,000 euro.
  • NIHR UCLH BRC grant on Developing approaches to personalised medicine in cardiovascular disease, a feasibility study. For 75,000 pound.
  • NIHR UCLH BRC grant on Translating -omics data for precision drug-development and re-purposing. For 50,000 pound.
  • NWO MyDigiTwin: Using Big-Data to put a cardiovascular digital twin into the hands of people. For 500,000 euro.
  • Network development grant, UMC Utrecht. For 16,000 euro.
  • Project Grant, British Heart Foundation on Evaluating combination therapeutics for CVD prevention using Mendelian randomization and phenome-wide scans. For 255,000 pound.
  • Springboard Population Science Fellowship on Genetically guided drug development methodologies. UCL excellence fellowship for 100,000 pound. 



  • 2022 European Atherosclerosis Society Young Investigator Award for outstanding publication.
  • 2017 Shortlisted for the London Cardiovascular Society Young Investigator Award.
  • 2017,2016 (2x) Pharmacoepidemiology and Drug Safety: best reviewer.
  • 2015 Journal of Clinical Epidemiology: reviewer of the year.
  • 2014 Royal College of Veterinary Surgeons: knowledge award bursary.
  • 2012 The Dutch epidemiology association: prize for best oral presentation.

Research Output (43)

Human Genomics and Drug Development

Schmidt Amand F., Hingorani Aroon D., Finan Chris 1 Feb 2022, In: Cold Spring Harbor perspectives in medicine. 12

Cochrane corner:PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease

Carter John Paul, Hingorani Aroon D., Wilkins John, Schmidt Amand Floriaan 1 Jan 2022, In: Heart (British Cardiac Society). 108 , p. 14-15 2 p.

Assessment of practical applicability and clinical relevance of a commonly used LDL-C polygenic score in patients with severe hypercholesterolemia

Tromp Tycho R., Cupido Arjen J., Reeskamp Laurens F., Stroes Erik S.G., Hovingh G. Kees, Defesche Joep C., Schmidt Amand F., Zuurbier Linda Jan 2022, In: Atherosclerosis. 340 , p. 61-67 7 p.

Cardiovascular risk prediction in type 2 diabetes:a comparison of 22 risk scores in primary care settings

Dziopa Katarzyna, Asselbergs Folkert W., Gratton Jasmine, Chaturvedi Nishi, Schmidt Amand F. 2022, In: Diabetologia. 65 , p. 644-656 13 p.

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

Gordillo-Marañón María, Zwierzyna Magdalena, Charoen Pimphen, Drenos Fotios, Chopade Sandesh, Shah Tina, Engmann Jorgen, Chaturvedi Nishi, Papacosta Olia, Wannamethee Goya, Wong Andrew, Sofat Reecha, Kivimaki Mika, Price Jackie F., Hughes Alun D., Gaunt Tom R., Lawlor Deborah A., Gaulton Anna, Hingorani Aroon D., Schmidt Amand F., Finan Chris Dec 2021, In: Nature Communications. 12 , p. 1-12

Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease

Schmidt Amand F., Hunt Nicholas B., Gordillo-Marañón Maria, Charoen Pimphen, Drenos Fotios, Kivimaki Mika, Lawlor Deborah A., Giambartolomei Claudia, Papacosta Olia, Chaturvedi Nishi, Bis Joshua C., O’Donnell Christopher J., Wannamethee Goya, Wong Andrew, Price Jackie F., Hughes Alun D., Gaunt Tom R., Franceschini Nora, Mook-Kanamori Dennis O., Zwierzyna Magdalena, Sofat Reecha, Hingorani Aroon D., Finan Chris 24 Sep 2021, In: Nature Communications. 12 , p. 1-10 10 p.

Second asymptomatic carotid surgery trial (ACST-2):a randomised comparison of carotid artery stenting versus carotid endarterectomy

Halliday Alison, Bulbulia Richard, Bonati Leo H., Chester Johanna, Cradduck-Bamford Andrea, Peto Richard, Pan Hongchao, Potter John, Henning Eckstein Hans, Farrell Barbara, Flather Marcus, Mansfield Averil, Mihaylova Boby, Rahimi Kazim, Simpson David, Thomas Dafydd, Sandercock Peter, Gray Richard, Molyneux Andrew, Shearman Cliff P., Rothwell Peter, Belli Anna, Herrington Will, Judge Parminder, Leopold Peter, Mafham Marion, Gough Michael, Cao Piergiorgio, MacDonald Sumaira, Bari Vasha, Berry Clive, Bradshaw S., Brudlo Wojciech, Clarke Alison, Cox Robin, Fathers Susan, Gaba Kamran, Gray Mo, Hayter Elizabeth, Holliday Constance, Kurien Rijo, Lay Michael, Poorthuis Michiel, Schmidt Andrej, de Borst Gert J., Moll Frans L., Toorop Raechel, van der Worp Bart H., Vonken Evert J., Kappelle Jaap L., 18 Sep 2021, In: The Lancet. 398 , p. 1065-1073 9 p.

No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease:A Mendelian Randomization Analysis

Mensah-Kane Josephine, Schmidt Amand F., Hingorani Aroon D., Finan Chris, Chen Yutang, van Duijvenboden Stefan, Orini Michele, Lambiase Pier D., Tinker Andrew, Marouli Eirini, Munroe Patricia B., Ramírez Julia 18 Feb 2021, In: Frontiers in Genetics. 12 10 p.

Risk Factors and Prevalence of Dilated Cardiomyopathy in Sub-Saharan Africa:Protocol for a Systematic Review

Fundikira Lulu Said, Chillo Pilly, van Laake Linda W, Mutagaywa Reuben Kato, Schmidt Amand Floriaan, Kamuhabwa Appolinary, Kwesigabo Gideon, Asselbergs Folkert W 21 Jan 2021, In: JMIR Research Protocols. 10

Establishing reference intervals for triglyceride-containing lipoprotein subfraction metabolites measured using nuclear magnetic resonance spectroscopy in a UK population

Joshi Roshni, Wannamethee Goya, Engmann Jorgen, Gaunt Tom, Lawlor Deborah A., Price Jackie, Papacosta Olia, Shah Tina, Tillin Therese, Whincup Peter, Chaturvedi Nishi, Kivimaki Mika, Kuh Diana, Kumari Meena, Hughes Alun D., Casas Juan P., Humphries Steve E., Hingorani Aroon D., Schmidt A. Floriaan, Jan 2021, In: Annals of Clinical Biochemistry. 58 , p. 47-53 7 p.

All research output

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