Department for Developmental Origins of Disease (DDOD)

Department for Developmental Origins of Disease (DDOD)

DDOD Brain Center

The DDOD-lab studies how adverse early life events, like (extreme) preterm birth or hypoxic-ischemic perinatal events, lead to injury in the developing brain and how this impacts neurodevelopmental outcome in the long run. We explore the pathophysiological mechanisms of early brain injury and focus on the development of novel therapeutic neuroprotective and neuroregenerative strategies to improve outcome after neonatal brain damage.

Research interests / topics uitklapper, klik om te openen

Brain damage in the earliest stages of life can have devastating effects on the quality of life. This condition affects thousands of children each year in the Netherlands. Survivors report a wide range of consequences, such as childhood epilepsy and cerebral palsy. These disorders often affect motor functioning, cause hypersensitivity and impair social behavior and cognition.

The Department for Developmental Origins of Disease (DDOD), an integral part of the division Woman & Baby, includes several research groups and is involved in (bio)medical teaching.

The research performed at the DDOD laboratory is translational of nature and can be dissected into six complementary and synergistic research lines. All research teams collaborate throughout the various projects, highlighting the collaborative environment at the DDOD.

We take a true bench-to-bedside approach by using clinically relevant cell- and animal-models to closely mimic brain injury in the human newborn and to test new treatment options via clinically applicable routes relevant to the target patient. We closely collaborate with the department of Neonatology to translate our preclinical findings to the infants at the Neonatal Intensive Care Unit.

Group members

Group members of DDOD-lab


The Department for Developmental Origins of Disease hosts various types of internship positions:

  • Laboratory sciences (MLO, HLO)
  • Biomedical bachelor research projects
  • Biomedical master research projects
  • Writing assignments

You can always send in an application. Please send a letter of interest with your CV to


More about our education activitities.

Key publications

Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study

Lisanne M Baak, Nienke Wagenaa, Niek E van der Aa, Floris Groenendaal, Jeroen Dudink, Maria Luisa Tataranno, et al. The Lancet Neurology, Volume 21, Issue 6, P528-536, June 2022

Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury

Myrna J. V. Brandt, Cora H. Nijboer, Isabell Nessel, Tatenda R. Mutshiya, Adina T. Michael-Titus, Danielle S. Counotte, Lidewij Schipper, Niek E. van der Aa, Manon J. N. L. Benders and Caroline G. M. de Theije Nutrients 2022, 14(1)

Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels

Michael A. van der Kooij, Liliana Rojas-Charry, Maryam Givehchi, Christina Wolf, Diones Bueno, Sabine Arndt, Stefan Tenzer, Lorenzo Mattioni, Giulia Treccani, Annika Hasch, Michael J. Schmeisser, Caterina Vianello, Marta Giacomello & Axel Methner Journal of Molecular Medicine volume 100, pages 1441–1453 (2022)

Anatomical development of the cerebellothalamic tract in embryonic mice

Daniël B. Dumas, Simona V. Gornati, Youri Adolfs, Tomomi Shimogori, R. Jeroen Pasterkamp, Freek E. Hoebeek Cells 2022, 11(23), 3800

Mesodiencephalic junction GABAergic inputs are processed separately from motor cortical inputs in the basilar pons

Ayoub J. Khalil, Huibert D. Mansvelder, Laurens Witter iScience Volume 25, Issue 7, 104641, July 15, 2022

Show more publications

Contact information

Postal address: Wilhelmina Kinderziekenhuis, Lundlaan 6, room KC.03.068.0, 3584 EA, Utrecht. 

T 088 - 755 43 59


Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not