Immune Evasion - Group van Strijp

Immune Evasion - Group van Strijp

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Identification of (novel) bacterial proteins and functional characterization of their potential as immune evasion molecule. In the first place these molecules explain why pathogenic bacteria are able to survive and replicate in the human body. Next, they lead researchers directly to key immunological functions. Also they are leads for anti-inflammatory therapy in our Drugs form Bugs program, using structured peptides as mimics. Finally they represent essential virulence factors and therefore prime targets for vaccine strategies and antibody therapy.

Research program uitklapper, klik om te openen

Infection and Immunity

Research interests uitklapper, klik om te openen

Innate immunity


Bacterial infections

Host-pathogen interaction


Contact uitklapper, klik om te openen

Yvonne Hagenaar


Related website

Utrecht Evasion - Immune evasion

Group members uitklapper, klik om te openen

prof. dr. J.A.G. van Strijp   Full Professor


Dr. András Spaan

Dr. Beatrix Förster-Schäfer

Dr. Carla de Haas

Dr. Daphne Stapels

Dr. Kirsten Koymans

Dr. Kok van Kessel

Research technicians

Adinda Bisschop

Anneroos Velthuizen

Piet Aerts

PhD students

Leonardo Cecotto

Rita Cruz


Erik Heezius


Yvonne Hagenaar

Join our group uitklapper, klik om te openen

Check for availability for bachelor and master level research internships with Kok van kesselor Bart Bardoel  

Key publications uitklapper, klik om te openen

  1. Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Jan Lebbink R, Haas PA, Henry T, Spaan AN. “Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin“. Nat Microbiol. 2018 June; 3:708–717 (Pubmed: 29736038) View
  2. de Jong NWM, Ramyar KX, Guerra FE, Nijland R, Fevre C, Voyich JM, McCarthy AJ, Garcia BL, van Kessel KPM, van Strijp JAG, Geisbrecht BV, Haas PA. “Immune evasion by a staphylococcal inhibitor of myeloperoxidase”. Proc Natl Acad Sci USA. 2017 Aug 14. pii: 201707032 (Pubmed: 28808028) View
  3. Koymans KJ, Feitsma LJ, Brondijk TH, Aerts PC, Lukkien E, Lössl P, van Kessel KP, de Haas CJ, van Strijp JA, Huizinga EG. “Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3)”. Proc Natl Acad Sci USA. 2015 Sep 1;112(35):11018-23 (Pubmed: 26283364) View
  4. Vrieling M, Koymans KJ, Heesterbeek DA, Aerts PC, Rutten VP, de Haas CJ, van Kessel KP, Koets AP, Nijland R, van Strijp JA. “Bovine Staphylococcus aureus Secretes the Leukocidin LukMF’ To Kill Migrating Neutrophils through CCR1”. MBio. 2015 Jun 4;6(3):e00335 (Pubmed: 26045537) View
  5. Surewaard BG, Nijland R, Spaan AN, Kruijtzer JA, de Haas CJ, van Strijp JA. “Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles”. PLoS Pathog. 2012;8(3):e1002606. (Pubmed: 22457627) View

PhD theses uitklapper, klik om te openen

Immune recognition of Staphylococcus aureus wall teichoic acid

Rob van Dalen


The art of Phospholipase A2-IIA: New insights into the host-pathogen battle

Vincent P. van Hensbergen

Crouching neutrophils, hidden bacteria

Yuxi Zhao


 Targeting Phagocytes: Learning from Staphylococcus aureus

Angelino Tromp


See all theses

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