Group van Wijk

Group van Wijk

Research interests uitklapper, klik om te openen

Chronic inflammatory disorders such as Inflammatory Bowel Disease (IBD) and Juvenile Idiopathic Arthritis (JIA) represent a major health burden affecting over 10 million people in Europe alone. Current treatments suppress but do not cure disease, and there is still a fundamental gap in our understanding of how inflammation persists. My group focuses on T cell development, regulation and plasticity in health and chronic inflammation and addresses conceptual and mechanistic immunological questions with a strong link to the clinic. We are especially interested in what happens locally, in the (inflamed) tissues. We combine front-running profiling techniques such as (single-cell) RNA-sequencing, epigenetics, TCR sequencing, and CyTOF with (customized) functional assays. The ultimate goal is to break the self-sustaining loop of chronic inflammation.


  • Naïve T cell development, heterogeneity, function, and imprinting
  • Regulatory T cell functional programming and adaptation in tissues and inflammation
  • Early T cell development in humans (neonates, breast milk and gut tissues)
  • T cell aging and immune resilience (neonatal thymectomy, stem cell transplantation, elderly) 
  • Mechanisms and side effects of (novel) targeted immune interventions in chronic inflammation  (IBD, AD)
  • T cell tissue adaptation in health and inflammation (skin, gut, joint, blood) 
  • Mechanisms of checkpoint inhibitor induced toxicity
  • Biomarker discovery for (at-home) monitoring and prediction of chronic inflammatory diseases (JDM, IBD, AD)  
  • Molecular classification of chronic inflammatory diseases
  • Autologous stem cell transplantation for autoimmune diseases

Keypublications uitklapper, klik om te openen

See: research output group van Wijk

Members Group van Wijk uitklapper, klik om te openen


  • Jorg Calis
  • José ter Linde
  • Theo van den Broek (guest)                             

Research technicians

PhD students

  • Saskia Veldkamp             
  • Anoushka Samat             
  • Mick van Eijs                     
  • Coco Dekkers                    
  • Lisanne Lutter                   
  • Eelco Brand                       
  • Coco Dekkers                    
  • Elise Saager                       
  • Roselie Achten (guest)
  • Irena Muffels (guest)
Group van Wijk

Clinical principle investigators collaborations/co-supervisors

  • Prof. Dr. Bas Oldenburg (gastroenterology)
  • Dr. Herma Fidder (gastroenterology)
  • Prof. Dr. Marjolein de Bruijn (dermatology)
  • Dr. Judith Thijs (dermatology)
  • Dr. Annet van Royen-Kerkhof (pediatric immunology/rheumatology)
  • Dr. Marc Jansen (pediatric immunology/rheumatology)
  • Dr. Bas Vastert (pediatric immunology/rheumatology)
  • Dr. Karijn Suijkerbuijk (medical oncology)
  • Dr. Helen Leavis (clinical immunology)
  • Prof. Dr. Louis Bont (pediatric infectious diseases)
  • Dr. Koos Jansen (pediatric intensive care)
  • Dr. Peter van Hasselt (pediatric metabolic diseases) 

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