Group van Loosdregt-Vastert
About uitklapper, klik om te openen
Together Jorg van Loosdregt (fundamental scientists) and Bas Vastert (pediatric rheumatologist/scientist) lead the pediatric rheumatology translational research group in the University Medical Center Utrecht (The Netherlands). Our mission is to increase our understanding of the molecular mechanisms underlying Juvenile Idiopathic Arthritis (JIA), and translating these findings into novel therapeutics. JIA is a disease that affects 1/1000 children and can lead to impaired severe loss of quality of life. Our group combines both fundamental and clinically orientated research projects. We believe that bringing these fields of research, and researchers, together facilitates translational research allowing for more efficient transition of experimental findings to the clinic.
Research programs uitklapper, klik om te openen
Infection and Immunity
Child Health
Research interests uitklapper, klik om te openen
Epigenetics and transcriptomics in JIA
Identification of therapeutic targets for JIA treatment
Clinical trials to improve JIA treatment and care
Contacts uitklapper, klik om te openen
Jorg van Loosdregt
Bas Vastert
Related websites
Group members uitklapper, klik om te openen
Group leaders: Bas Vastert and Jorg van Loosdregt
Postdoc uitklapper, klik om te openen
Dr. Jorg Calis (affiliated researcher)
Research technicians
- Kim Klarenaar (collaboration with Dr. Marianne Boes)
- Rianne Scholman
- Lyanne Sijbers
Clinician-Scientist
- Arjen Leek
Visiting scientists
- Greta Rogani
PhD students
- Jelleke de Jonge (collaboration with Dr. Joost Swart and Dr. Sytze de Roock)
- Lotte Nijhuis
- Lucas Picavet
- Anouk Verwoerd
- Ellen van Vroonhoven
Key publications uitklapper, klik om te openen
- Ter Haar, N. M., et al. (2019). "Treatment to Target Using Recombinant Interleukin-1 Receptor Antagonist as First-Line Monotherapy in New-Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five-Year Follow-Up Study." Arthritis Rheumatol 71(7): 1163-1173. View
- Ter Haar, N. M., et al. (2018). "Reversal of Sepsis-Like Features of Neutrophils by Interleukin-1 Blockade in Patients With Systemic-Onset Juvenile Idiopathic Arthritis." Arthritis Rheumatol 70(6): 943-956. View
- Peeters, J. G., et al. (2015). "Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression." Cell Rep 12(12): 1986-1996. View
- van Loosdregt, J., et al. (2013). "Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity." Immunity 39(2): 259-271. View
- van Loosdregt, J., et al. (2013). "Canonical Wnt signaling negatively modulates regulatory T cell function." Immunity 39(2): 298-310. View
PhD thesis uitklapper, klik om te openen
Transcriptional and epigenetics mechanisms underlying autoimmune diseases: towards identification of novel therapeutic targets - Janneke Peeters 2019
Autoinflammation: from monogenic to complex diseases - Nienke ter Haar 2018
Collaborations uitklapper, klik om te openen
Our research acitivities are closely linked to the department of Pediatric Rheumatology and Immunology in the Wilhelmina Children’s Hospital, University Medical Center Utrecht.
Within the Center of Translational Immunoloy, we closely collaborate with the group of Femke van Wijk. Together we supervise 1 PhD student in a PhD trajectory on residential T cells in Synovial fluid in JIA.
We collaborate with multiple groups in the Netherlands and abroad
Grants uitklapper, klik om te openen
Prizes uitklapper, klik om te openen
> Pediatric Rheumatology European Association - Young Investigator Meeting Nienke ter Haar Best Basic Presentation (2015, 2018)
> Dutch Pediatric Society (NVK) - Young Investigator Prize Nienke ter Haar 3rd prize (2018)
> Pediatric Rheumatology European Association Lotte Nijhuis Kourir award 2018 for relevant research to patients (2018)
In the media uitklapper, klik om te openen
13 Dec 2018: Best Behandeling kinderen met jeugdreuma - UMC Utrecht
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