drs. P.Q.Q. (Nico M.) Wert

drs. P.Q.Q. (Nico M.) Wert

Professor Emeritus
drs. P.Q.Q. (Nico M.) Wert
  • Immuno/reuma ERN



Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.

Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.

He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.

Side Activities


Gezondheidsraad advies CVS

ZonMW commissie programma translationeel onderzoek en adulte stamcellen, adviesgroep medische producten (2009-2016)

Evaluatie beoordeling NFU expertise centra

Council PRES (2004-2010)

Council PRINTO National representative for NL (2001-2014)

ERN RITA HCP Member Representative (2017) and since 2019 ERN RITA coordinator

Reviewer for all major rheumatology Journals, Blood, Lancet, NEJM


Member of EBMT working party for autoimmune diseases (Chair R Saccardi, Florence Italy)

Member of the ZONWM programme committee Translational Adult Stem cell research

Member of Advisory working group consisting of external experts for RIVM (Corona related) (2021- )

Member of the European Medicines Agency (EMA) expert group for pediatric rheumatology

Member of the ZONMW programme committee Priority medicines for children

Member of the advisory council Ter Meulen Fonds

Member of the Drug Safety Monitoring board of the adalumimab trial for uveitis (NHS, England)

Member of the board for the Dutch pediatric rheumatology society, for education and research (2001-2010)

Member of the board for Utrecht pediatric postgraduate courses (1999-2010)

Member of the Scientific Advisory Council of the Dutch League for Rheumatology (Nationaal Reumafonds, 2006-2009)

Member of the Utrecht study group for the development of the electronic patient file into clinical paractise (2005-2009)

Member of the EBMT working party for inborn errors and immunodeficiencies (1996-2008)

Potential Conflicts of Interest

Dr. Wulffraat has regular interaction with pharmaceutical and other industrial partners. These activities were continued until 2018 . Since then he is the chair of the European rare Diseases Network (RITA) and receives grants from the EU to sustain this network. As per may 2022 he will receive a part time salary for this. ERN RITA has supported international clinical practice guidelines. UMCU has received incidental funding (up to €10,000 as multi sponsoring per event as  support for research and educational activities deployed by the Pediatric Rheumatology European Society. This is a non-for profit organization. He has received support from the Dutch medical Insurance company het Zilveren Kruis for a study on the use of an App (as a medical device) specifically for patients with chronic arthritis

Fellowship and Awards

FP7 Grant Pharmachild


Div. ZON MW Grants



AbbVie (bijdrage Reuma2Go)

Roche (bijdrage Reuma2Go)

ERN coordinator RITA

ZonMW grant Chronic Fatique QFS and JIA

Research Output (598)

Association of adalimumab trough concentrations and treatment response in patients with juvenile idiopathic arthritis

Doeleman Martijn J H, de Roock Sytze, El Amrani Mohsin, van Maarseveen Erik M, Wulffraat Nico M, Swart Joost F 24 Dec 2021, In: Rheumatology (Oxford, England). 61 , p. 377-382 6 p.

Genomic Health Literacy Interventions in Pediatrics:Scoping Review

Gupta Aarushi, Cafazzo Joseph A., IJzerman Maarten J., Swart Joost F., Vastert Sebastiaan, Wulffraat Nico M., Benseler Susanne, Marshall Deborah, Yeung Rae, Twilt Marinka Dec 2021, In: Journal of Medical Internet Research. 23

Evaluation of Real-World Healthcare Resource Utilization and Associated Costs in Children with Juvenile Idiopathic Arthritis:A Canadian Retrospective Cohort Study

Grazziotin Luiza R., Currie Gillian, Twilt Marinka, Ijzerman Maarten J., Kip Michelle M.A., Koffijberg Hendrik, Benseler Susanne M., Swart Joost F., Vastert Sebastiaan J., Wulffraat Nico M., Yeung Rae S.M., Johnson Nicole, Luca Nadia J., Miettunen Paivi M., Schmeling Heinrike, Marshall Deborah A., Sep 2021, In: Rheumatology and therapy. 8 , p. 1303-1322 20 p.

Mandibular range of motion in children with juvenile idiopathic arthritis with and without clinically established temporomandibular joint involvement and in healthy children: a cross-sectional study

de Sonnaville Willemijn F C, Speksnijder Caroline M, Zuithoff Nicolaas P A, Verkouteren Daan R C, Wulffraat Nico W, Steenks Michel H, Rosenberg Antoine J W P 3 Jul 2021, In: Pediatric Rheumatology. 19

Survey of adult and paediatric rheumatology patients suggests information about COVID-19 vaccination will aid uptake

Beesley Richard P., Costello Wendy, Angevare Saskya P., Wouters Carine, Wulffraat Nico, Uziel Yosef 1 Jul 2021, In: Rheumatology (United Kingdom). 60 , p. 3474-3475 2 p.

Maximum bite force in children with juvenile idiopathic arthritis with and without clinical established temporomandibular joint involvement and in healthy children: a cross-sectional study

de Sonnaville Willemijn, Speksnijder Caroline, Zuithoff NPA, Verkouteren Daan, Wulffraat Nico M., Steenks MH, Rosenberg AJWP Jul 2021, In: Journal of Oral Rehabilitation. 48 , p. 774-784 11 p.

Monitoring patients with juvenile idiopathic arthritis using health-related quality of life

Doeleman Martijn J.H., de Roock Sytze, Buijsse Nathan, Klein Mark, Bonsel Gouke J., Seyfert-Margolis Vicki, Swart Joost F., Wulffraat Nico M. 22 Mar 2021, In: Pediatric Rheumatology. 19 , p. 40

Explaining placebo effects in an online survey study:Does ‘Pavlov’ ring a bell?

Smits Rosanne M., Veldhuijzen Dieuwke S., Hartman Tim Olde, Peerdeman Kaya J., van Vliet Liesbeth M., van Middendorp Henriët, Rippe Ralph C.A., Wulffraat Nico M., Evers Andrea W.M. 11 Mar 2021, In: PLoS ONE. 16

Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases

Furer Victoria, Rondaan Christien, Agmon-Levin Nancy, Van Assen Sander, Bijl Marc, Kapetanovic Meliha Crnkic, De Thurah Annette, Mueller-Ladner Ulf, Paran Daphna, Schreiber Karen, Warnatz Klaus, Wulffraat Nico M., Elkayam Ori 24 Feb 2021, In: RMD Open. 7

Costs of medication use among patients with juvenile idiopathic arthritis in the Dutch healthcare system

Kip Michelle M A, de Roock Sytze, Currie Gillian, Marshall Deborah A, Grazziotin Luiza R, Twilt Marinka, Yeung Rae S M, Benseler Susanne M, Schreijer Maud A, Vastert Sebastiaan J, Wulffraat Nico, van Royen-Kerkhof Annet, Swart Joost F, IJzerman Maarten J 28 Dec 2020, In: Expert Review of Pharmacoeconomics and Outcomes Research. 21 , p. 975-984 10 p.

All research output

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