prof. dr. M.N.N. Verhagen

prof. dr. M.N.N. Verhagen

Associate Professor
prof. dr. M.N.N. Verhagen
  • Center for Translational Immunology (CTI) Research
  • Dermatology and Allergology

Research Programs

Infection & Immunity



Edward Knol is a biomedical scientist and immunologist in the departments of Immunology and Dermatology/Allergology at the University Medical Center Utrecht. He did his PhD training in the Blood Transfusion Service of the University of Amsterdam and had a postdoc position at Johns Hopkins University in Baltimore. His scientific research focuses on allergic diseases, in particularly eczema and food allergy. The research focusses on 1) improved insights in pathomechanisms, 2) explore new treatment options, 3) improve current diagnostics and establish new diagnostics platforms. In his career Edward Knol discovered CD63 as the basophil activation marker, described the important role of the peanut allergen Ara h 2 and described A20/TNFAIP3 dysregulation in atopic dermatitis. He is involved in several (inter)national collaborations and is Secretary General of the Dutch Society of Immunology (~1400 members).

Within the University Medical Center he holds a teaching position and chairs the education committee of the University Utrecht graduate school Immunity and Infection (50 master and 170 PhD students). He is coordinator and examiner of: 1) Course Clinical Immunology for 3rd years students Biomedical Sciences, 2) Course Immune Therapy for 2nd years student Medicine and 3) Course Infection and Immunity for 3rd years Students at the Technical University Eindhoven. 

At the international level Edward Knol has organised 3 European Academy of Allergy and Clinical Immunology (EAACI) Winter schools and was the chair of the Scientific Program Committee of the EAACI annual meetings in 2014-2016. In addition, since 2019 he is Vice President Congresses of EAACI. 

Specialties: Immunology, Allergy, Food Allergy, Atopic Dermatitis, Basophilic granulocytes, T lymphocytes, allergy diagnostic tests, basophil activation test



Google Scholar:

Scopus H-factor: h-index: 51

Research gate: h-index: 54, : RG score: 46,95

Google Scholar: h-index: 60 


Side Activities

2009- Chair Educational committee Master and PhD program Graduate School Immunity and Infection, University van Utrecht. Supervising the training program of 50 Master students and 180 PhD students.

2013- Co-director FOCIS Center of Excellence, Utrecht Infection and Immunity Center.

2014- Member taskforce IgE diagnostics, EAACI

2015- Member guideline committee Allergy Immunotherapy, EAACI

2015-2018 Steering committee member FOCIS, representing EAACI

2014-2016 Chair Scientific Program Committee (SPC) EAACI, coordinating EAACI annual meetings in 2015 (Barcelona) and 2016 (Vienna).

2019- Vice President EAACI Congresses and Events, coordinating all scientific meetings of European Academy of Allergy and Clinical Immunology ranging from 8500 participants to 280 participants per meeting


Editorial Board memberships:

- Dutch Journal for Allergology

- Clinical and Translational Allergy

- Clinical and Experimental Allergy




Research Output (262)

Measurement of IgE to hazelnut allergen components cannot replace hazelnut challenge in Dutch adults

Lyons Sarah A, Welsing Paco M J, Hakobyan Mariam, Kansen Hannah M, Knol Edward F, Otten Henny G, van Ree Ronald, Knulst André C, Le Thuy-My 16 Nov 2021, In: Allergy. 77 , p. 1559-1569 11 p.

Risk factors for conjunctivitis in atopic dermatitis patients treated with dupilumab: results from the bioday registry

Achten R., Van der Rijst L., Bakker D., Spekhorst L., Boesjes C., Zuithoff N., Knol E., Van Luijk C., De Boer J., Thijs J., De Graaf M., De Bruin-Weller M. Nov 2021, In: Allergy. 76 , p. 11-11

T-cell subsets in the skin and their role in inflammatory skin disorders

Kortekaas Krohn Inge, Aerts Joeri L, Breckpot Karine, Goyvaerts Cleo, Knol Edward, Van Wijk Femke, Gutermuth Jan 6 Oct 2021, In: Allergy. 77 , p. 827-842 16 p.

Unraveling heterogeneity in pediatric atopic dermatitis::identification of serum biomarker based patient clusters

Bakker D., de Graaf M., Nierkens S., Delemarre E., Knol E., van Wijk F., de Bruin-Weller M., Drylewicz J., Thijs J. Oct 2021, In: Journal of Investigative Dermatology. 141 , p. S189-S189

Seeking diagnostic and prognostic biomarkers for childhood bacterial pneumonia in sub-Saharan Africa:study protocol for an observational study

Valim Clarissa, Olatunji Yekin Ajauoi, Isa Yasir Shitu, Salaudeen Rasheed, Golam Sarwar, Knol Edward F, Kanyi Sheriffo, Jammeh Abdoulie, Bassat Quique, de Jager Wilco, Diaz Alejandro A, Wiegand Roger C, Ramirez Julio, Moses Marsha A, D'Alessandro Umberto, Hibberd Patricia L, Mackenzie Grant A 30 Sep 2021, In: BMJ Open. 11 , p. 1-10 10 p.

Allergy:Type I, II, III, and IV

Knol Edward F, Gilles Stefanie 14 Jul 2021, p. 31-41 11 p.

Systemic and local evidence for complement involvement in chronic spontaneous urticaria

Alizadeh Aghdam Mehran, van den Elzen Mignon, van Os-Medendorp Harmieke, van Dijk Marijke R, Knol Edward F, Knulst André C, Röckmann Heike, Otten Henny G Jul 2021, In: Clinical and Translational Allergy. 11 , p. 1-8

COVID-19 pandemic and allergen immunotherapy - an EAACI survey

Pfaar Oliver, Agache Ioana, Bonini Matteo, Brough Helen Annaruth, Chivato Tomás, Del Giacco Stefano R, Gawlik Radoslaw, Gelincik Aslı, Hoffmann-Sommergruber Karin, Jutel Marek, Klimek Ludger, Knol Edward F, Lauerma Antti, Ollert Markus, O'Mahony Liam, Mortz Charlotte G, Palomares Oscar, Riggioni Carmen, Schwarze Jürgen, Skypala Isabel, Torres María José, Untersmayr Eva, Walusiak-Skorupa Jolanta, Chaker Adam, Giovannini Mattia, Heffler Enrico, Jensen-Jarolim Erika, Quecchia Cristina, Sandoval-Ruballos Mónica, Sahiner Umit, Tomić Spirić Vesna, Alvaro-Lozano Montserrat 2 Mar 2021, In: Allergy. 76 , p. 3504-3516 13 p.

Unraveling heterogeneity in pediatric atopic dermatitis:identification of serum biomarker based patient clusters

Bakker Daphne S, Graaf Marlies de, Nierkens Stefan, Delemarre Eveline M, Knol Edward, van Wijk Femke, de Bruin-Weller Marjolein S, Drylewicz Julia, Thijs Judith L 2021, In: The Journal of Allergy and Clinical Immunology. 149 , p. 125-134 10 p.

EASI p-EASI: Predicting disease severity in atopic dermatitis patients treated with dupilumab using a combination of serum biomarkers

Bakker Daphne S, Ariens Lieneke F M, Giovannone Barbara, Hijnen DirkJan, Delemarre Eveline M, Knol Edward, Nierkens Stefan, de Bruin-Weller Marjolein S, Thijs Judith L, Drylewicz Julia Dec 2020, In: Allergy. 75 , p. 3287-3289 3 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not