ir. N. (Jaap) van Uitslag

ir. N. (Jaap) van Uitslag

Full Professor
ir. N. (Jaap) van Uitslag
  • Rheumatology & Clinical Immunology



Jacob M. van Laar is Professor at the Department of Rheumatology and Clinical Immunology at UMC Utrecht, the Netherlands. After obtaining his MD and PhD degrees at Leiden University, he specialised in Internal Medicine and Rheumatology in Leiden University Medical Center and worked at the Department of Rheumatology as clinical academic in various roles from 1997-2007, interrupted by a postdoctoral research fellowship at the National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, USA. From 2007 until 2013 he held a Chair in Clinical Rheumatology at Newcastle University, and post as honorary consultant rheumatologist at The James Cook University Hospital, Middlesbrough, UK. He has been working as Professor of Rheumatology at UMC Utrecht since 1 November 2013. His main research interests involve clinical and pathogenetic aspects of systemic sclerosis and rheumatoid arthritis, aimed at improving the outcome of patients with rheumatic diseases by innovative clinical-translational research.

Side Activities

Founding Member Stichting ARCH

Member Scientific Advisory Board Edith Busch Stiftung

Member of EUSTAR (EULAR Scleroderma Trials and Research)

Ad hoc basis: expert advice Central Board of Appeal, Medical Ethics Committee Noord Brabant, liability disputes; consultancies pharmaceutical companies (; postgraduate teaching (including Artrose Instituut Nederland); patient consultations (Reumazorg Zuid-West Nederland).



Fellowship and Awards

Marie Parijs award for pioneering work in the field of clinical stem cell research in rheumatic autoimmune diseases (2002, Leiden University Medical Center)

ZonMW Clinical Fellow (2007)

Fellow of the Royal College of Physicians Edinburgh (2009)

NVLE Award (2015) 

Research Output (304)

Using real-world data to dynamically predict flares during tapering of biological DMARDs in rheumatoid arthritis:development, validation, and potential impact of prediction-aided decisions

van der Leeuw Matthijs S., Messelink Marianne A., Tekstra Janneke, Medina Ojay, van Laar Jaap M., Haitjema Saskia, Lafeber Floris, Veris-van Dieren Josien J., van der Goes Marlies C., den Broeder Alfons A., Welsing Paco M.J. 23 Mar 2022, In: Arthritis research & therapy. 24 , p. 1-11

Positron Emission Tomography to Improve Assessment of Interstitial Lung Disease in Patients With Systemic Sclerosis Eligible for Autologous Stem Cell Transplantation

Broens Bo, van der Laken Conny J, Zwezerijnen Gerben J C, Nossent Esther J, Meijboom Lilian J, Spierings Julia, de Vries-Bouwstra Jeska K, van Laar Jacob M, Voskuyl Alexandre E 2022, In: Frontiers in Immunology. 13 , p. 923869

Current Smoking Negatively Affects the Response to Methotrexate in Rheumatoid Arthritis in a Dose-responsive Way, Independently of Concomitant Prednisone Use

Safy-Khan Mary, de Hair Maria J H, Welsing Paco M J, van Laar Jacob M, Jacobs Johannes W G, 1 Oct 2021, In: Journal of Rheumatology. 48 , p. 1504-1507 4 p.

Clinical Practice Audit on the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in the Netherlands

Dirikgil Ebru, Jonker Jacqueline T, Tas Sander W, Verburgh Cornelis A, Soonawala Darius, Hak A Elisabeth, Remmelts Hilde H F, IJpelaar Daphne, Laverman Gozewijn D, Rutgers Abraham, van Laar Jacob M, Moen Hein J Bernelot, Verhoeven Peter M J, Rabelink Ton J, Bos Willem Jan W, Teng Y K Onno, Oct 2021, In: Kidney International Reports. 6 , p. 2671-2678 8 p.

Microarray testing in patients with systemic lupus erythematosus identifies a high prevalence of CpG DNA-binding antibodies

Brunekreef Tammo, Limper Maarten, Melchers Rowena, Mathsson-Alm Linda, Dias Jorge, Hoefer Imo, Haitjema Saskia, van Laar Jacob M, Otten Henny Oct 2021, In: Lupus science & medicine. 8

Predictors for progressive fibrosis in patients with connective tissue disease associated interstitial lung diseases

Chiu Yu Hsiang, Spierings Julia, de Jong Pim A., Hoesein Firdaus Mohamed, Grutters Jan C., van Laar Jacob M., Voortman Mareye 18 Aug 2021, In: Respiratory Medicine. 187 8 p.

EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis

Nagy György, Roodenrijs Nadia M T, Welsing Paco M J, Kedves Melinda, Hamar Attila, van der Goes Marlies C, Kent Alison, Bakkers Margot, Pchelnikova Polina, Blaas Etienne, Senolt Ladislav, Szekanecz Zoltan, Choy Ernest H, Dougados Maxime, Jacobs Johannes Wg, Geenen Rinie, Bijlsma Johannes Wj, Zink Angela, Aletaha Daniel, Schoneveld Leonard, van Riel Piet, Dumas Sophie, Prior Yeliz, Nikiphorou Elena, Ferraccioli Gianfranco, Schett Georg, Hyrich Kimme L, Mueller-Ladner Ulf, Buch Maya H, McInnes Iain B, van der Heijde Désirée, van Laar Jacob M 18 Aug 2021, In: Annals of the Rheumatic Diseases. 81 , p. 20-33 14 p.

Outcomes linked to eligibility for stem cell transplantation trials in diffuse cutaneous systemic sclerosis

Spierings Julia, Nihtyanova Svetlana I, Derrett-Smith Emma, Clark Kristina E N, van Laar Jacob M, Ong Voon, Denton Christopher P 26 Jul 2021, In: Rheumatology (Oxford, England). 61 , p. 1948-1956 9 p.

Identification and prediction of difficult-to-treat rheumatoid arthritis patients in structured and unstructured routine care data:results from a hackathon

Messelink Marianne A., Roodenrijs Nadia M.T., van Es Bram, Hulsbergen-Veelken Cornelia A.R., Jong Sebastiaan, Overmars L. Malin, Reteig Leon C., Tan Sander C., Tauber Tjebbe, van Laar Jacob M., Welsing Paco M.J., Haitjema Saskia 8 Jul 2021, In: Arthritis Research and Therapy. 23 , p. 1-10


Van Laar J. M., Lei A., Safy-Khan M., Almquist J., Astbury C., Belvisi M., Platt A., Prothon S., Samuelsson S., Svanberg P., Keen C. Jun 2021, In: Annals of the Rheumatic Diseases. 80 , p. 253-254

All research output

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