drs. N.O. (Linda W.) van Martens

drs. N.O. (Linda W.) van Martens

Associate Professor
drs. N.O. (Linda W.) van Martens
  • Division of Heart & Lungs



Linda W. Van Laake, MD, PhD obtained her medical degree at Maastricht University and her PhD (title: Cardiac Recovery by Stem and Progenitor Cells) at Utrecht University, after which she continued her scientific career as a postdoctoral researcher at the Gladstone Institutes, University of California, San Francisco (USA). In 2011 she became Assistant Professor at the Department of Cardiology of the University Medical Center Utrecht and the Hubrecht Institute Utrecht, the Netherlands. In addition, she works as a clinical cardiologist specialized in heart failure.

Dr. Van Laake’s team explores novel approaches to regenerate the heart using stem- and progenitor cells. Many cardiovascular diseases, such as heart failure and myocardial infarction, are associated with loss of functional cardiomyocytes (heart muscle cells). A focus on the understanding of fundamental cardiac developmental – and repair processes will promote the recapitulation of cardiac differentiation in vitro. Currently, the team is investigating the influence of circadian or “day-night” rhythms on cardiac development and regeneration.

Combing a variety of novel approaches together with a greater understanding of how heart development and repair work, Dr. Van Laake and her team strive to create better personalized heart failure therapies.


Side Activities

  • Member of the Translational Committee of the Heart Failure Association, European Society of Cardiology
  • Selected participant of the Postgraduate Course in Heart Failure of the Heart Failure Association, European Society of Cardiology
  • Member of the Young ICIN (Interuniversity Cardiology Institute of the Netherlands) committee
  • Selected participant of the Jacob Jongbloed Talent Society Program, Circulatory Health, UMC Utrecht
  • Participant of “The Young Academy on Wheels”; an outreach program by the Young Academy of the KNAW to bring high school students in contact with science and scientists
  • Selected participant of UMC Utrecht female leadership program Steyn Parvé
  • Member of the Young Health Council, an advisory body to the government and parliament on the current level of knowledge with respect to public health issues and health (services) research
  • Nucleus Member of the Working Group on Cellular Biology of the Heart, European Society of Cardiology
  • Editorial Board member of Stem Cell Reviews and Reports, the Netherlands Heart Journal, and the Journal of Geriatric Cardiology
  • Regular reviewer for Stem Cells, Journal of Molecular and Cellular Cardiology, Stem Cell Reports, Differentiation, Stem Cell Research, European Journal of Heart Failure
  • Reviewer for NWO-ZonMw, Netherlands Heart Foundation, FWO (Flanders Research Foundation), KWF (Netherlands Cancer Foundation), National Research Foundation Luxembourg

 Conflict of interest: none

Fellowship and Awards


  • UMCU Clinical Research Talent Fellowship, 2014-2016
  • Jacob Jongbloed Talent Society grant for multidisciplinary team effort “Heart Failure with Preserved Ejection Fraction in Metabolic Syndrome”, 2014
  • Novartis personal grant for participation in the Postgraduate Course in Heart Failure of the European Society of Cardiology, 2014-2015
  • Netherlands Heart Foundation Dekker personal grant “Arts in Opleiding tot Specialist” 2013-2016
  • European Society of Cardiology First Contact Initiative Grant 2013
  • Veni ZonMw grant 2011-2014, a personal grant that is part of the Innovational Research Incentives Scheme of NWO (Netherlands Organization for Scientific Research)
  • Keystone Scholarship (Pathological and Physiological Regulation of Cardiac Hypertrophy), 2008
  • ICIN (Interuniversity Cardiology Institute of the Netherlands) Fellowship 2007 for post-doctoral training in the Gladstone Institute of Cardiovascular Disease, San Francisco.
  • Netherlands Heart Foundation grant for working visit to the US “Functional integration of transplanted human embryonic stem-cell derived cardiomyocytes”, 2006
  • Van Walree Fund grant, Royal Netherlands Academy of Arts and Sciences; 2004


  • Heineken Young Scientist Award for Medicine, of the KNAW (Royal Netherlands Academy of Arts and Sciences), 2012
  • Young Investigator Award, European Society of Cardiology Congress, Stockholm, 2010
  • Einthoven Dissertatieprijs 2009 (award for the best PhD thesis in Cardiology of 2008)
  • European Society of Cardiology Basic Cardiovascular Science Travel Award, 2008

Research Output (91)

Pirfenidone Has Anti-fibrotic Effects in a Tissue-Engineered Model of Human Cardiac Fibrosis

Bracco Gartner Tom, Crnko S, Leiteris Laurynas, van Adrichem Iris, van Laake Linda W., Bouten Carlijn V. C., Goumans Marie-Jose, Suyker Willem, Sluijter Joost P.G., Hjortnaes Jesper 11 Mar 2022, In: Frontiers in Cardiovascular Medicine. 9 , p. 1-13

Initiation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock during out of hours versus working hours is not associated with increased mortality

van der Wal P. S., Kraaijeveld A. O., van der Heijden J. J., van Laake L. W., Platenkamp M., de Heer L. M., Braithwaite S. A., van Eijk M. M.J., Hermens J. A.J., Cremer O. L., Donker D. W., Meuwese C. L. 2022, In: International Journal of Artificial Organs. 45 , p. 301-308 8 p.

Prognostically relevant periprocedural myocardial injury and infarction associated with percutaneous coronary interventions:A Consensus Document of the ESC Working Group on Cellular Biology of the Heart and European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Bulluck Heerajnarain, Paradies Valeria, Barbato Emanuele, Baumbach Andreas, Bøtker Hans Erik, Capodanno Davide, De Caterina Raffaele, Cavallini Claudio, Davidson Sean M., Feldman Dmitriy N., Ferdinandy Péter, Gili Sebastiano, Gyöngyösi Mariann, Kunadian Vijay, Ooi Sze Yuan, Madonna Rosalinda, Marber Michael, Mehran Roxana, Ndrepepa Gjin, Perrino Cinzia, Schüpke Stefanie, Silvain Johanne, Sluijter Joost P.G., Tarantini Giuseppe, Toth Gabor G., Van Laake Linda W., Von Birgelen Clemens, Zeitouni Michel, Jaffe Allan S., Thygesen Kristian, Hausenloy Derek J. 14 Jul 2021, In: European heart journal. 42 , p. 2630-2642 13 p.

Morning pulmonary artery pressure measurements by CardioMEMS are most stable and recommended for pressure trends monitoring

Crnko S, Brugts J J, Veenis J F, de Jonge N, Sluijter J P G, Oerlemans M I F, van Laake L W 10 Jun 2021, In: Netherlands Heart Journal. 29 , p. 409-414 6 p.

Donor-Derived Testicular Germ Cell Cancer in a Heart Transplant Recipient

Oerlemans Marish I.F.J., Groenewegen Gerard, Vink Aryan, van Laake Linda W., van der Kaaij Niels P., de Jonge Nicolaas Jun 2021, In: JACC: CardioOncology. 3 , p. 322-325 4 p.

A Roadmap to Cardiac Tissue-Engineered Construct Preservation:Insights from Cells, Tissues, and Organs

Sampaio-Pinto Vasco, Janssen Jasmijn, Chirico Nino, Serra Margarida, Alves Paula M, Doevendans Pieter A, Voets Ilja K, Sluijter Joost P G, van Laake Linda W, van Mil Alain 28 May 2021, In: Advanced materials. 33 , p. 1-24

Propensity score-based analysis of long-term outcome of patients on HeartWare and HeartMate 3 left ventricular assist device support

Numan Lieke, Ramjankhan Faiz Z., Oberski Daniel L., Oerlemans Martinus I.F.J., Aarts Emmeke, Gianoli Monica, Van Der Heijden Joris J., De Jonge Nicolaas, Van Der Kaaij Niels P., Meuwese Christiaan L., Mokhles Mostafa M., Oppelaar Anne Marie, De Waal Eric E.C., Asselbergs Folkert W., Van Laake Linda W. Apr 2021, In: ESC heart failure. 8 , p. 1596-1603 8 p.

Cardiac circadian rhythms in time and space:The future is in 4D

Chirico Nino, Van Laake Linda W, Sluijter Joost P G, van Mil Alain, Dierickx Pieterjan Apr 2021, In: Current Opinion in Pharmacology. 57 , p. 49-59 11 p.

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

Maas Renee G.C., Lee Soah, Harakalova Magdalena, Snijders Blok Christian J.B., Goodyer William R., Hjortnaes Jesper, Doevendans Pieter A.F.M., Van Laake Linda W., van der Velden Jolanda, Asselbergs Folkert W., Wu Joseph C., Sluijter Joost P.G., Wu Sean M., Buikema Jan W. 19 Mar 2021, In: STAR protocols. 2

From the freezer to the clinic:Antifreeze proteins in the preservation of cells, tissues, and organs

Tas Roderick P., Sampaio-Pinto Vasco, Wennekes Tom, van Laake Linda W., Voets Ilja K. 3 Mar 2021, In: EMBO Reports. 22 , p. 1-8

All research output

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