drs. D.E.E. (T.P.C.) van Koopman

drs. D.E.E. (T.P.C.) van Koopman

Associate Professor - medical
drs. D.E.E. (T.P.C.) van Koopman
  • Neurochirurgen



My research focusses on the bench to bedside development of devices that improve outcome of patients with a neurosurgical disease. 

I started my research carreer as a PhD in the group of Prof CAF Tulleken and Prof A van der Zwan at the UMC Utrecht, and I co-invented several ways to make a bypass in the brain. These techniques were ultimately used to treat patients.

After my PhD, during my neurosurgical trianing, I invented and co-developed a new sealant (in the media it is referred to as 'plaster') to prevent cerebrospinal fluid leakage after brain surgery.  I did all developents under public private flag together with Polyganics BV, and the intellectual property (IP) was transferred from UMC Utrecht to this company to make the technique available for patients. The device (formally called 'Liqoseal') is now standard of care in Europe and under research in the USA.

A few years ago I started to do research with Augmented Reality to inform patients, train residents and provide active guidance during brain surgery. The IP I developed was tranferred to a UMC Utrecht spinoff called 'Augmedit'. I combine my function as a neurosurgeon, nowadays both in the UMC Utrecht and the University Medical Center in Zurich, Switserland, with being Chief Medical Officer of this company. My research group in the UMCU works closely together with Augmedit, the Prinsess Maxima Center and University Medical Center Zurich to design optimal software to inform patients, train residents and to ultimately prevent complications during brainsurgery. 

Side Activities

Consultant Polyganics BV, Groningen, The Netherlands

Chief Medical Officer Augmedit bv, Amsterdam, The Netherlands

Neurosurgeon University Medical Center Zurich, Switserland

Research Output (47)

Safety and biodegradability of a synthetic dural sealant patch (Liqoseal) in a porcine cranial model

Kinaci Ahmet, Bergmann Wilhelmina, van Thoor Sander, Redegeld Saskia, van der Zwan Albert, van Doormaal Tristan P C Dec 2021, In: Animal models and experimental medicine. 4 , p. 398-405 8 p.

Neurocap Use for the Treatment of Iatrogenic Neuropathic Pain:Preliminary Operative Results in 3 Patients

de Ru J. Alexander, Hans Hans G.X., Tijink Bernard M., van Doormaal Tristan P.C. 1 Sep 2021, In: Ear, Nose and Throat Journal. 100 , p. 830S-834S

Fully automatic brain tumor segmentation for 3D evaluation in augmented reality

Fick Tim, Van Doormaal Jesse A.M., Tosic Lazar, Van Zoest Renate J., Meulstee Jene W., Hoving Eelco W., Van Doormaal Tristan P.C. Aug 2021, In: Neurosurgical Focus. 51 , p. 1-8 8 p.

Single-arm, open-label, multicentre first in human study to evaluate the safety and performance of dural sealant patch in reducing CSF leakage following elective cranial surgery:The ENCASE trial

Van Doormaal Tristan, Germans Menno R., Sie Mariska, Brouwers Bart, Carlson Andrew, Dankbaar Jan Willem, Fierstra Jorn, Depauw Paul, Robe Pierre, Regli Luca 28 Jul 2021, In: BMJ Open. 11 , p. 1-6

Ex vivo evaluation of a multilayered sealant patch for watertight dural closure:cranial and spinal models

Kinaci A., van Thoor S., Redegeld S., Tooren M., van Doormaal T. P.C. 23 Jul 2021, In: Journal of Materials Science: Materials in Medicine. 32 , p. 1-10

Visual Outcomes after Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas:Our Institutional Experience

Van Essen Max J., Muskens Ivo S., Lamba Nayan, Belunek Stephan F.J., Van Der Boog Arthur T.J., Amelink G. Johan, Gosselaar Peter H., Van Doormaal Tristan P.C., Stades Aline M.E., Verhoeff Joost J.C., Van Genderen Maria M., Eenhorst Christine A.E., Broekman Marike L.D. 1 Jul 2021, In: Journal of Neurological Surgery, Part B: Skull Base. 82 , p. E79-E87

Cerebrospinal fluid leakage after cranial surgery in the pediatric population—a systematic review and meta-analysis

Slot Emma M.H., van Baarsen Kirsten M., Hoving Eelco W., Zuithoff Nicolaas P.A., van Doormaal Tristan P.C. May 2021, In: Child's Nervous System. 37 , p. 1439-1447 9 p.

Holographic patient tracking after bed movement for augmented reality neuronavigation using a head-mounted display

Fick T., van Doormaal J. A.M., Hoving E. W., Regli L., van Doormaal T. P.C. Apr 2021, In: Acta Neurochirurgica. 163 , p. 879-884 6 p.

Current Accuracy of Augmented Reality Neuronavigation Systems:Systematic Review and Meta-Analysis

Fick Tim, van Doormaal Jesse A.M., Hoving Eelco W., Willems Peter W.A., van Doormaal Tristan P.C. Feb 2021, In: World Neurosurgery. 146 , p. 179-188 10 p.

Long-term feasibility of the new sutureless excimer laser-assisted non-occlusive anastomosis clip in a pig model

de Boer B., van Doormaal T. P.C., Tulleken C. A.F., Regli L., van der Zwan A. Feb 2021, In: Acta Neurochirurgica. 163 , p. 573-581 9 p.

All research output

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