ing. W.X. (Wilton A) van Engels - SF

ing. W.X. (Wilton A) van Engels - SF

Full Professor
ing. W.X. (Wilton A) van Engels - SF
  • Anesthesiology

Research Programs

Circulatory Health



Wilton van Klei received his PhD in 2002 and completed his postgraduate training as anesthesiologist in the Netherlands (2006. After that he did a clinical and research fellowship in perioperative medicine (Ottawa, Ontario, 2007). He returned to the Netherlands to complete a fellowship in cardiothoracic anesthesia (2009), including training in TEE. From 2007 till 2012, he was the Medical Director of the Outpatient Preoperative Evaluation Clinic of the UMC Utrecht. Subsequently, he was the Chair of the Department of Anesthesiology and the Director Research and Education of the Division of Anesthesiology, Intensive Care and Emergency Medicine of the UMC Utrecht (2013-2021). Curently, his primary affiliation is at the University Health Network Toronto / University of Toronto, but he holds a small appointment as a research professor at the UMC Utrecht.


His interests focus on improving care for high-risk surgical patients, and involve collaborations with cardiologists, surgeons, clinical chemists, and epidemiologists within the UMC Utrecht’s Circulatory Health research programme. He is supervising several PhD students on clinical research projects in the field of cardiovascular perioperative medicine. Most projects aim to unravel further the etiology, detection and treatment of asymptomatic myocardial injury after surgery. He considers hisself a specialist in perioperative medicine.
Perioperative medicine starts before surgery with a preanesthesia assessment and currently often ends with the patient leaving the recovery room, except for a responsibility for postoperative pain management. However, anesthesiologists should be involved not only in pain management, but also in providing postoperative care on general wards, monitoring vital functions and monitoring for complications likely to be related to surgery and anesthesia. In fact, anesthesiologists should extend what they are doing in the operating room to the surgical floor in order to improve patient outcomes. He is working towards this goal by initiating research in those areas where evidence for optimal treatment is absent.

Side Activities

No side activities

Fellowship and Awards

2011 Research Award of the International Anesthesia Research Society (IARS)

Research Output (204)

The comparative and added prognostic value of biomarkers to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all-cause mortality in patients who undergo noncardiac surgery

Vernooij Lisette M, van Klei Wilton A, Moons Karel Gm, Takada Toshihiko, van Waes Judith, Damen Johanna Aag 21 Dec 2021, In: The Cochrane database of systematic reviews. 2021 , p. 1-439

Intraoperative hypotension and delirium among older adults undergoing transcatheter aortic valve replacement

Wesselink Esther M., Abawi Masieh, Kooistra Nynke H. M., Kappen Teus H., Agostoni Pierfrancesco, Emmelot-Vonk Marielle, Pasma Wietze, Klei Wilton A., Jaarsveld Romy C., Dongen Charlotte S., Doevendans Pieter P. A. F. M., Slooter Arjen J. C., Stella Pieter R. Nov 2021, In: Journal of the American Geriatrics Society. 69 , p. 3177-3185 9 p.

Gastric fluid volume in adults after implementation of a liberal fasting policy:a prospective cohort study

Marsman Marije, Pouw Niels, Moons Leon M.G., van Klei Wilton A., Kappen Teus H. Sep 2021, In: British Journal of Anaesthesia. 127 , p. e85-e87

Supervision, Interprofessional Collaboration, and Patient Safety in Intensive Care Units during the COVID-19 Pandemic

Hennus Marije P, Young John Q, Hennessy Martina, Friedman Karen A, de Vries Bas, Hoff Reinier G, O'Connor Enda, Patterson Aileen, Curley Gerard, Thakker Krima, van Dam Marjel, van Dijk Diederik, van Klei Wilton A, Ten Cate Olle Sep 2021, In: ATS scholar. 2 , p. 397-414 18 p.

Patient selection for routine troponin monitoring after noncardiac surgery

Weersink Corien S.A., van Waes Judith A.R., Grobben Remco B., Nathoe Hendrik M., van Klei Wilton A. 20 Jul 2021, In: Journal of the American Heart Association. 10 , p. 1-9

L’hypoxémie pendant la sédation chez le patient adulte:une étude observationnelle rétrospective

van Schaik Eva P C, Blankman Paul, Van Klei Wilton A, Knape Hans J T A, Vaessen Paul H H B, Braithwaite Sue A, van Wolfswinkel Leo, Schellekens Willem-Jan M 20 Apr 2021, In: Canadian Journal of Anaesthesia. 68 , p. 1349-1357 9 p.

Added value of subjective assessed functional capacity before non-cardiac surgery in predicting postoperative myocardial injury

Marsman Marije, van Waes Judith A R, Grobben Remco B, Weersink Corien S A, van Klei Wilton A Mar 2021, In: European Journal of Preventive Cardiology. 28 , p. 262-269 8 p.

Variation in perioperative cerebral and hemodynamic monitoring during carotid endarterectomy

Fassaert Leonie MM, Toorop Raechel J., Petri Bart Jeroen, Westerink Jan, van Hattum Eline S., Kappelle L. Jaap, Kappelle L. Jaap, van Klei Wilton A., de Borst Gert J. 2021, In: Annals of Vascular Surgery. 77 , p. 153-163 11 p.

Associations between Preoperative Biomarkers and Cardiac Surgery-Associated Acute Kidney Injury in Elderly Patients:A Cohort Study

Verwijmeren Lisa, Bosma Madeleen, Vernooij Lisette M., Linde Esther M., Dijkstra Ineke M., Daeter Edgar J., Van Dongen Eric P.A., Van Klei Wilton A., Noordzij Peter G. 2021, In: Anesthesia and Analgesia. 133 , p. 570-577 8 p.

Emergency Airway Management in Patients with COVID-19:A Prospective International Multicenter Cohort Study

Wong Danny J.N., El-Boghdadly Kariem, Owen Ruth, Johnstone Craig, Neuman Mark D., Andruszkiewicz Paweł, Baker Paul A., Biccard Bruce M., Bryson Gregory L., Chan Matthew T.V., Cheng Ming Hua, Chin Ki Jinn, Coburn Mark, Jonsson Fagerlund Malin, Lobo Clara A., Martinez-Hurtado Eugenio, Myatra Sheila N., Myles Paul S., Navarro Guillermo, O'Sullivan Ellen, Pasin Laura, Quintero Kathleen, Shallik Nabil, Shamim Faisal, Van Klei Wilton A., Ahmad Imran 2021, In: Anesthesiology. 135 , p. 292-303 12 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not