ir. C. (Cornelis) van der Nes

ir. C. (Cornelis) van der Nes

Full Professor
ir. C. (Cornelis) van der Nes
  • Pulmonology patient care
  • Strategic theme Child Health



The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.

Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.

Side Activities

Chairman of Cystic Fibrosis Center Utrecht

Chairman of Dutch Cystic Fibrosis Research Network

Member of Medical Advisory Board Dutch Cystic Fibrosis Committee

Member of Research committee Wilhelmina Children’s Hospital Utrecht

Member of Medical Ethical Committee University Medical Center Utrecht

Medical advisor of Sioux CCM

Board Member of Malawi Mission Work Team

Chair of CoreNetwork CF of European Refence Network of Excellence for rare lung diseases (ERN-LUNG) 2015-now

Member steering committee Clinical Trial Office UMC Utrecht 2017-now

Coordinator of European HIT-CF program 2018-now

Board member of Lung Alliance Netherlands (LAN) 2020-now

Reviewer for Am J Resp Crit Care Med, European Respir J and many others

Reviewer for the expertise centra voor zeldzame ziekte voor de NFU 2021 - heden

Chair of therapeutic foundation 2021 - heden


Potential Conflicts of Interest

Dr. van der Ent reports grants from GSK, grants from Nutricia, grants from TEVA, grants from Gilead, grants from Vertex, grants from ProQR, grants from Proteostasis, grants from Galapagos NV, grants from Eloxx and grants from Santhera, all paid to UMCU; In addition, Dr. van der Ent has a patent 10006904 with royalties paid.

Fellowship and Awards

European CF young investigator meeting award 2011. A functional CFTR assay using primary cystic fibrosis organoids

European CF basic science meeting award 2011. Treatment with VX809 and VX770 in rectal CF organoids expressing  uncommon CFTR genotypes

European CF basic science meeting award 2012. Characterizing altered inflammatory signaling in CFTR-defective

bronchial epithelial cells

National symposium Dutch CF foundation award 2011. Complement mediated phagocytosis is reduced in CF monocytes.

Research Output (528)

Prediction of Real-World Long-Term Outcomes of People with CF Homozygous for the F508del Mutation Treated with CFTR Modulators

Muilwijk Danya, Bierlaagh Marlou, van Mourik Peter, Kraaijkamp Jasmijn, van der Meer Renske, van den Bor Rutger, Heijerman Harry, Eijkemans René, Beekman Jeffrey, van der Ent Kors 16 Dec 2021, In: Journal of Personalized Medicine. 11 , p. 1-12

Immunometabolic factors in adolescent chronic disease are associated with Th1 skewing of invariant Natural Killer T cells

Ververs Francesca, Engelen Suzanne, Nuboer Roos, Vastert SJ, van der Ent Kors , van 't Land Belinda, Garssen Johan, Monaco Claudia, Boes Marianne, Schipper Henk 11 Oct 2021, In: Scientific Reports. 11 11 p.

CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy

de Poel Eyleen, Spelier Sacha, Korporaal Ricardo, Lai Ka Wai, Boj Sylvia F., Conrath Katja, van der Ent Cornelis K., Beekman Jeffrey M. 15 Sep 2021, In: Frontiers in Molecular Biosciences. 8

A new era for people with cystic fibrosis

Bierlaagh Marlou C., Muilwijk Danya, Beekman Jeffrey M., van der Ent Cornelis K. Sep 2021, In: European Journal of Pediatrics. 180 , p. 2731-2739 9 p.

PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections

van Eijk Martin, van Dijk Albert, van der Ent Cornelis K., Arets Hubertus G.M., Breukink Eefjan, van Os Nico, Adrichem Roy, van der Water Sven, Lino Gómez Rita, Kristensen Maartje, Hessing Martin, Jekhmane Shehrazade, Weingarth Markus, Veldhuizen Ruud A.W., Veldhuizen Edwin J.A., Haagsman Henk P. Sep 2021, In: Biochimica et Biophysica Acta - General Subjects. 1865 , p. 1-11

Internet and smartphone-based ecological momentary assessment and personalized advice (PROfeel) in adolescents with chronic conditions:A feasibility study

Nap-van der Vlist Merel M., Houtveen Jan, Dalmeijer Geertje W., Grootenhuis Martha A., van der Ent Cornelis K., van Grotel Martine, Swart Joost F., van Montfrans Joris M., van de Putte Elise M., Nijhof Sanne L. Sep 2021, In: Internet Interventions. 25 , p. 1-10

Diagnostic accuracy of Ara h 2 for detecting peanut allergy in children

Kansen Hannah M., van Erp Francine C., Meijer Yolanda, Gorissen Dianne M.W., Stadermann Marike, van Velzen Maartje F., Keusters Willem R., Frederix Geert W.J., Knulst André C., van der Cornelis K., Le Thuy My Aug 2021, In: Clinical and Experimental Allergy. 51 , p. 1069-1079 11 p.

Parent-Child Dyadic Coping and Quality of Life in Chronically Diseased Children

Nap-van der Vlist Merel M., van der Wal Reine C., Grosfeld Eva, van de Putte Elise M., Dalmeijer Geertje W., Grootenhuis Martha A., van der Ent Cornelis K., van den Heuvel-Eibrink Marry M., Swart Joost F., Bodenmann Guy, Finkenauer Catrin, Nijhof Sanne L. 28 Jul 2021, In: Frontiers in Psychology. 12

Breast development in a 7 year old girl with CF treated with ivacaftor:An indication for personalized dosing?

Jeyaratnam Joshena, van der Meer Renske, Berkers Gitte, Heijerman Harry Gm, Beekman Jeffrey M, van der Ent Cornelis K 23 Jun 2021, In: Journal of Cystic Fibrosis. 20 , p. e63-e66

Role of parents in fatigue of children with a chronic disease:A cross-sectional study

Kramer Niels, Nijhof Sanne L., Van De Putte Elise M., Ketelaar Marjolijn, Grootenhuis Martha A., Van Der Ent Kors, Swart Joost F., Van Grotel Martine, Dalmeijer Geertje W., Nap-Van Der Vlist Merel M. 21 May 2021, In: BMJ paediatrics open. 5 , p. 1-9

All research output

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