prof. P.Q. (Pim) van der Binkhorst

prof. P.Q. (Pim) van der Binkhorst

Full Professor
prof. P.Q. (Pim) van der Binkhorst
  • Gezonde Vaten

Research Programs

Circulatory Health



I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website:  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Side Activities

2020- honorary appointment Departmentof Cardiology, University Medical Center Groningen

2020- National member of Scientific Advisory Board LifeLiens Cohort Study

2019- Member of Science & Innovation Committee, Dutch Society of Cardiology

2019- Member of the Scientific Counsel of the Dutch Heart Registration (NHR)

2019- Nucleus member of the Council on Cardiovascular Genomics, European Society of Cardiology

2018- Member of the Workgroup Acute Coronary Syndrome, Dutch Society of Cardiology

2020-2021 Member of the Supervisory Board Netherlands Heart Institute

2017-2021 Co-founder and manager non-medical affairs Mijnhuisarts B.V. (primary care facility province of Groningen)

2017- Director and owner of the holding Generalis Procuratio B.V. 

2016-2020 Local member of Scientific Advisory Board LifeLines Cohort Study, LifeLines B.V.

2015-2018 co-organizer & member of the Programing Committee  Netherlands Heart Days

2015-2015 Member of the Scientific Sessions Programing Committee, American Heart Association

2014- Member of the Workgroup Interventional Cardiology, Dutch Society of Cardiology

2010-2015 Associate Editor European Journal of Heart Failure

2010-2016 Associate Editor BMC Medical Genetics

2010-2012 member of grant committee Netherlands Heart Foundation

2009-2018 Honorary appointment Department of Cardiovascular Sciences, University of Leicester, UK

2008-2008 Academic Editor of medical journal PLoS Medicine

2008-2012 Editorial Advisory Panel of medical journal Clinical Science

Ad-hoc reviewer for medical journals (including, but not limited to Lancet, Nat Genet, JAMA, PLoS Med, Circulation, Circ Res, J Am Coll Cardiol, Arterioscler Thromb Vasc Biol, Hypertension, Eur Heart J, Hum Mol Genet)

Ad-hoc grant reviewer (including but not limited to; Netherlands Heart Foundation; Netherlands Organisation for Scientific Research (NWO, Netherlands); The Research Foundation Flanders (FWO, Belgium); Medical Research Councel (MRC, South Africa); Danish Councel for Independent Research (FI, Denmark);  National Center of Science and Technology Evaluation (Ministry of Education and Science, Republic of Kazakhstan); Heart Research UK (UK). 

Fellowship and Awards



Winner of Humanimal – One Health Innovation Challenge 2015 with the Durrer Center (of which I was Chief Scientific Officer). Price for “Best Professional Idea Flevoland” for our Open One Health Biobank proposal (€ 50,000.--)

2013Scientific Excellence Award from the Board of the UMCG (€ 100,000.--)
2010 Excellence Award from the Netherlands Foundation for Cardiovascular Excellence for Scientific, Clinical and Presenting Excellence (€ 50,000.--)


2012NWO Clinical Fellowship (90.700.441); Systems and functional genomics strategies to identify novel vulnerability genes for heart failure. €160,000.--
2007VENI Fellowship (916.76.170) of the Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research (NWO); Telomere length in cardiovascular disease; differential expression and prognostic value (€ 248,000.--)
2008ICIN Fellowship (€ 45,000.--) of the Interuniversity Cardiology Institute of the Netherlands



Research Output (316)

Minimally invasive surgery or stenting for left anterior descending artery disease - meta-analysis

Gianoli Monica, de Jong Anne R, Jacob Kirolos A, Namba Hanae F, van der Kaaij Niels P, van der Harst Pim, J L Suyker Willem Jun 2022, In: IJC Heart and Vasculature. 40 , p. 1-8

Cost Analysis From a Randomized Comparison of Immediate Versus Delayed Angiography After Cardiac Arrest

Camaro Cyril, Bonnes Judith L, Adang Eddy M, Spoormans Eva M, Janssens Gladys N, van der Hoeven Nina W, Jewbali Lucia S, Dubois Eric A, Meuwissen Martijn, Rijpstra Tom A, Bosker Hans A, Blans Michiel J, Bleeker Gabe B, Baak Rémon, Vlachojannis George J, Eikemans Bob J, van der Harst Pim, van der Horst Iwan C, Voskuil Michiel, van der Heijden Joris J, Beishuizen Bert, Stoel Martin, van der Hoeven Hans, Henriques José P, Vlaar Alexander P, Vink Maarten A, van den Bogaard Bas, Heestermans Ton A, de Ruijter Wouter, Delnoij Thijs S, Crijns Harry J, Jessurun Gillian A, Oemrawsingh Pranobe V, Gosselink Marcel T, Plomp Koos, Magro Michael, Elbers Paul W, van de Ven Peter M, Lemkes Jorrit S, van Royen Niels 1 Mar 2022, In: Journal of the American Heart Association. 11 , p. 1-17

Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events

van den Berg Victor J, Vroegindewey Maxime M, Umans Victor A, van der Harst Pim, Asselbergs Folkert W, Akkerhuis K Martijn, Kardys Isabella, Boersma Eric, 2 Feb 2022, In: Biomarkers. 27 , p. 264-269 6 p.

Der diagnostische und prognostischeWert der Koronarkalkmessung bei Patienten mit anhaltenden Brustschmerzen:Ein narrativer Uberblick

Koopman Moniek Y, Willemsen Robert T A, van der Harst Pim, van Bruggen Rykel, Gratama Jan Willem C, Braam Richard, van Ooijen Peter M A, Doggen Carine J M, Dinant Geert-Jan, Kietselaer Bas, Vliegenthart Rozemarijn 26 Jan 2022, In: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 194 , p. 257-265 9 p.

Association of Lipoprotein(a) With Atherosclerotic Plaque Progression

Kaiser Yannick, Daghem Marwa, Tzolos Evangelos, Meah Mohammed N, Doris Mhairi K, Moss Alistair J, Kwiecinski Jacek, Kroon Jeffrey, Nurmohamed Nick S, van der Harst Pim, Adamson Philip D, Williams Michelle C, Dey Damini, Newby David E, Stroes Erik S G, Zheng Kang H, Dweck Marc R 25 Jan 2022, In: Journal of the American College of Cardiology. 79 , p. 223-233 11 p.

Large HDL particles negatively associate with leukocyte counts independent of cholesterol efflux capacity:A cross sectional study in the population-based LifeLines DEEP cohort

Groenen Anouk G, Bazioti Venetia, van Zeventer Isabelle A, Chen Lianmin, Groot Hilde E, Balder Jan-Willem, Zhernakova Alexandra, van der Harst Pim, Rimbert Antoine, Kuivenhoven Jan Albert, Fu Jingyuan, Westerterp Marit 18 Jan 2022, In: Atherosclerosis. 343 , p. 20-27 8 p.

Relation of Iron Status to Prognosis After Acute Coronary Syndrome

Gürgöze Muhammed T, Kardys Isabella, Akkerhuis K Martijn, Oemrawsingh Rohit M, Groot Hilde E, van der Harst Pim, Umans Victor A, Kietselaer Bas, Ronner Eelko, Lenderink Timo, Asselbergs Folkert W, Manintveld Olivier C, Boersma Eric 16 Jan 2022, In: The American Journal of Cardiology. 168 , p. 22-30 9 p.

Early detection of obstructive coronary artery disease in the asymptomatic high-risk population:objectives and study design of the EARLY-SYNERGY trial

Ties Daan, van Dorp Paulien, Pundziute Gabija, van der Aalst Carlijn M, Gratama Jan Willem C, Braam Richard L, Kuijpers Dirkjan, Lubbers Daniël D, van der Bilt Ivo A C, Westenbrink B Daan, Wolcherink Martijn J Oude, Doggen Carine J M, Išgum Ivana, Nijveldt Robin, de Koning Harry J, Vliegenthart Rozemarijn, Oudkerk Matthijs, van der Harst Pim 13 Jan 2022, In: American Heart Journal. 246 , p. 166-177 12 p.

Dynamic Myocardial Perfusion CT for the Detection of Hemodynamically Significant Coronary Artery Disease

Nous Fay M A, Geisler Tobias, Kruk Mariusz B P, Alkadhi Hatem, Kitagawa Kakuya, Vliegenthart Rozemarijn, Hell Michaela M, Hausleiter Jörg, Nguyen Patricia K, Budde Ricardo P J, Nikolaou Konstantin, Kepka Cezary, Manka Robert, Sakuma Hajime, Malik Sachin B, Coenen Adriaan, Zijlstra Felix, Klotz Ernst, van der Harst Pim, Artzner Christoph, Dedic Admir, Pugliese Francesca, Bamberg Fabian, Nieman Koen Jan 2022, In: JACC. Cardiovascular imaging. 15 , p. 75-87 13 p.

Telomere length is independently associated with all-cause mortality in chronic heart failure

Romaine Simon P R, Denniff Matthew, Codd Veryan, Nath Mintu, Koekemoer Andrea, Anker Stefan D, Cleland John G, Filippatos Gerasimos, Levin Daniel, Metra Marco, Mordi Ify R, Ouwerkerk Wouter, Ter Maaten Jozine M, van Veldhuisen Dirk J, Zannad Faiez, Ng Leong L, van der Harst Pim, Lang Chim C, Voors Adriaan A, Nelson Christopher P, Samani Nilesh J Jan 2022, In: Heart. 108 , p. 124-129 6 p.

All research output

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