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ir. D.E.E. (Jan) van de Kasmi

ir. D.E.E. (Jan) van de Kasmi

Full Professor

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Research Output (249)

Expression of CD64 (Fc gamma RI) in skin of patients with acute GVHD

van Royen-Kerkhof A., Walraven V., Sanders E.A.M., de Weger R.A., van Wichen D.F., de Koning E., Thepen T., van de Winkel J.G.J., Leusen J.H.W. Dec 2011, In: Bone Marrow Transplantation. 46 , p. 1566-1569 4 p.

Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.

de Weers M., Tai Y-T, van der Veer M.S., Bakker J.M., Vink T., Jacobs D.C.H., Oomen L.A., Peipp M., Valerius T., Slootstra J.W., Mutis T., Bleeker W.K., Anderson K.C., Lokhorst H.M., van de Winkel J.G.J., Parren P.W.H.I. 2011, In: Journal of Immunology. 186 , p. 1840-1848 9 p.

Epidermal growth factor receptor (EGFR) antibody-induced antibody-dependent cellular cytotoxicity plays a prominent role in inhibiting tumorigenesis, even of tumor cells insensitive to EGFR signaling inhibition

Overdijk M.B., Verploegen S., van den Brakel J.H., Lammerts van Bueren J.J., Vink T., van de Winkel J.G.J., Parren P.W.H.I., Bleeker W.K. 2011, In: Journal of Immunology. 187 , p. 3383-3390 8 p.

Human kappa light chain targeted Pseudomonas exotoxin A--identifying human antibodies and Fab fragments with favorable characteristics for antibody-drug conjugate development

Kellner C., Bleeker W.K., Lammerts van Bueren J.J., Staudinger M., Klausz K., Derer S., Glorius P., Muskulus A., de Goeij B.E.C.G., van de Winkel J.G.J., Parren P.W.H.I., Valerius T., Gramatzki M., Peipp M. 2011, In: Journal of Immunological Methods. 371 , p. 122-133 12 p.

Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC.

Repp R., Kellner C., Muskulus A., Staudinger M., Mohseni Nodehi S., Glorius P., Akramiene D., Dechant M., Fey G.H., van Berkel P.H.C., van de Winkel J.G.J., Parren P.W.H.I., Valerius T., Gramatzki M., Peipp M. 2011, In: Journal of Immunological Methods. 373 , p. 67-78 12 p.

Quantitative analysis of the interaction strength and dynamics of human IgG4 half molecules by native mass spectrometry

Rose R.J., Labrijn A.F., van den Bremer E.T.J., Loverix S., Lasters I., van Berkel P.H.C., van de Winkel J.G.J., Schuurman J., Parren P.W.H.I., Heck A.J.R. 2011, In: Structure. 19 , p. 1274-1282 9 p.

Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca(2+) influx and induces streamers.

Beum P.V., Lindorfer M.A., Peek E.M., Stukenberg P.T., de Weers M., Beurskens F.J., Parren P.W.H.I., van de Winkel J.G.J., Taylor R.P. 2011, In: European Journal of Immunology. 41 , p. 2436-2446 11 p.

Molecular engineering to improve antibodies' anti-lymphoma activity

Peipp M., van de Winkel J.G.J., Valerius T. 2011, In: Best practice & Research. Clinical Haematology. 24 , p. 217-29 13 p.

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing

Lohse S., Derer S., Beyer T., Klausz K., Peipp M., Leusen J.H.W., van de Winkel J.G.J., Dechant M., Valerius T. 2011, In: Journal of Immunology. 186 , p. 3770-3778 9 p.

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden

Boross P., Jansen J.H.M., de Haij S., Beurskens F.J., van der Poel C.E., Bevaart L., Nederend M., Golay J., van de Winkel J.G.J., Parren P.W.H.I., Leusen J.H.W. 2011, In: Haematologica. 96 , p. 1822-30 9 p.

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