drs. Y.Z. (Olaf) Staring

drs. Y.Z. (Olaf) Staring

Full Professor
drs. Y.Z. (Olaf) Staring
  • Intensive Care Medicine

Research Programs

Infection & Immunity



Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:

1 - diagnostic uncertainty in early detection of sepsis

2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation

3 - decision support for diagnosis and treatment of sepsis

Cremer has been mentoring 16 PhD students to date.

Side Activities

Advisory boards

2021 - GlaxoSmithKline (otilimab drug development) - money paid to UMCU

2021 - Parexel (adrenomed ENCOURAGE program) - money paid to UMCU


Industry collaborations

2015-2019 - ImmuneXpress Inc. (Seattle, WA) – Unrestricted research grant (105K)

2021-2022 - Abionic SA (Epalinges, Switzerland) – Unrestricted research grant (60K)

2022-2024 - Prolira BV (Utrecht, Netherlands) - In kind contributions to research (50K)


Speaker fees

Committee for European Education in Anaesthesiology





Research Output (219)

Transportability and Implementation Challenges of Early Warning Scores for Septic Shock in the ICU:A Perspective on the TREWScore

Niemantsverdriet Michael S A, Varkila Meri R J, Vromen-Wijsman Jacqueline L P, Hoefer Imo E, Bellomo Domenico, van Vliet Martin H, van Solinge Wouter W, Cremer Olaf L, Haitjema Saskia 8 Feb 2022, In: Frontiers in medicine. 8

Delirium and long-term psychopathology following surgery in older adults

de Mul Nikki, van den Bos Lisa M E C, Kant Ilse M J, van Montfort Simone J T, Schellekens Willem-Jan M, Cremer Olaf L, Slooter Arjen J C 30 Jan 2022, In: Journal of Psychosomatic Research. 155 , p. 1-5

Initiation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock during out of hours versus working hours is not associated with increased mortality

van der Wal P. S., Kraaijeveld A. O., van der Heijden J. J., van Laake L. W., Platenkamp M., de Heer L. M., Braithwaite S. A., van Eijk M. M.J., Hermens J. A.J., Cremer O. L., Donker D. W., Meuwese C. L. 2022, In: International Journal of Artificial Organs. 45 , p. 301-308 8 p.

Predictors for extubation failure in COVID-19 patients using a machine learning approach

Fleuren Lucas M, Dam Tariq A, Tonutti Michele, de Bruin Daan P, Lalisang Robbert C A, Gommers Diederik, Cremer Olaf L, Bosman Rob J, Rigter Sander, Wils Evert-Jan, Frenzel Tim, Dongelmans Dave A, de Jong Remko, Peters Marco, Kamps Marlijn J A, Ramnarain Dharmanand, Nowitzky Ralph, Nooteboom Fleur G C A, de Ruijter Wouter, Urlings-Strop Louise C, Smit Ellen G M, Mehagnoul-Schipper D Jannet, Dormans Tom, de Jager Cornelis P C, Hendriks Stefaan H A, Achterberg Sefanja, Oostdijk Evelien, Reidinga Auke C, Festen-Spanjer Barbara, Brunnekreef Gert B, Cornet Alexander D, van den Tempel Walter, Boelens Age D, Koetsier Peter, Lens Judith, Faber Harald J, Karakus A, Entjes Robert, de Jong Paul, Rettig Thijs C D, Arbous Sesmu, Vonk Sebastiaan J J, Fornasa Mattia, Machado Tomas, Houwert Taco, Hovenkamp Hidde, Noorduijn Londono Roberto, Quintarelli Davide, Scholtemeijer Martijn G, de Beer Aletta A, 27 Dec 2021, In: Critical care (London, England). 25 , p. 1-10 10 p.

Source-specific host response and outcomes in critically ill patients with sepsis:a prospective cohort study

Peters-Sengers Hessel, Butler Joe M, Uhel Fabrice, Schultz Marcus J, Bonten Marc J, Cremer Olaf L, Scicluna Brendon P, van Vught Lonneke A, van der Poll Tom, 13 Dec 2021, In: Intensive Care Medicine. 48 , p. 92-102 11 p.

Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 - Insights from the PRoVENT-COVID study

Roozeman Jan-Paul, Mazzinari Guido, Serpa Neto Ary, Hollmann Markus W, Paulus Frederique, Schultz Marcus J, Pisani Luigi, , Cremer Olaf, de Lange Prof.dr. D.W. (Dylan) 3 Dec 2021, In: Journal of Critical Care. 68 , p. 31-37 7 p.

Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia

Pereverzeva Liza, Uhel Fabrice, Peters Sengers Hessel, Cremer Olaf L, Schultz Marcus J, Bonten Marc M J, Scicluna Brendon P, van der Poll Tom, Dec 2021, In: Annals of Intensive Care. 11 , p. 1-13 13 p.

De sCepsis voorbij:oratie

Cremer Olaf 5 Nov 2021, 26 p.

Rapid evaluation of Coronavirus Illness Severity (RECOILS) in intensive care:Development and validation of a prognostic tool for in-hospital mortality

Plečko Drago, Bennett Nicolas, Mårtensson Johan, Dam Tariq A, Entjes Robert, Rettig Thijs C D, Dongelmans Dave A, Boelens Age D, Rigter Sander, Hendriks Stefaan H A, de Jong Remko, Kamps Marlijn J A, Peters Marco, Karakus Attila, Gommers Diederik, Ramnarain Dharmanand, Wils Evert-Jan, Achterberg Sefanja, Nowitzky Ralph, van den Tempel Walter, de Jager Cornelis P C, Nooteboom Fleur G C A, Oostdijk Evelien, Koetsier Peter, Cornet Alexander D, Reidinga Auke C, de Ruijter Wouter, Bosman Rob J, Frenzel Tim, Urlings-Strop Louise C, de Jong Paul, Smit Ellen G M, Cremer Olaf L, Mehagnoul-Schipper D Jannet, Faber Harald J, Lens Judith, Brunnekreef Gert B, Festen-Spanjer Barbara, Dormans Tom, de Bruin Daan P, Lalisang Robbert C A, Vonk Sebastiaan J J, Haan Martin E, Fleuren Lucas M, Thoral Patrick J, Elbers Paul W G, Bellomo Rinaldo 15 Oct 2021, In: Acta Anaesthesiologica Scandinavica. 66 , p. 65-75 11 p.

Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome:results from three observational cohorts

Bos Lieuwe D J, Sjoding Michael, Sinha Pratik, Bhavani Sivasubramanium V, Lyons Patrick G, Bewley Alice F, Botta Michela, Tsonas Anissa M, Serpa Neto Ary, Schultz Marcus J, Dickson Robert P, Paulus Frederique, , Cremer Olaf, de Lange Prof.dr. D.W. (Dylan) 12 Oct 2021, In: The Lancet Respiratory Medicine. 9 , p. 1377-1386 10 p.

All research output

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