prof. dr. P.Q.Q. (Mervyn) Sonsbeek

prof. dr. P.Q.Q. (Mervyn) Sonsbeek

Associate Professor - medical
prof. dr. P.Q.Q. (Mervyn) Sonsbeek
  • Neurologen

Research Programs



Mervyn Vergouwen obtained his PhD degree at the University of Amsterdam / Academic Medical Center in 2009. The title of his PhD was ‘Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage – the role of coagulation and fibrinolysis’. From 2009-2010 he did a clinical/research stroke fellowship at the University of Toronto, Canada. After his return to the Netherlands, he worked as a postdoc at the Laboratory of Experimental Vascular Medicine at the Academic Medical Center to study the role of microthrombosis in the pathogenesis of delayed cerebral ischemia after subarachnoid hemorrhage in a mouse model. In 2011 he accepted a position as a staff neurologist at the UMC Utrecht and joined Prof. Gabriel Rinkel’s research group on aneurysmal subarachnoid hemorrhage.

His research focuses on unruptured intracranial aneurysms, diagnosis of (aneurysmal) subarachnoid hemorrhage, and brain injury after subarachnoid hemorrhage. This includes all processes that occur in the (sub)acute setting, including the initial hemorrhage and subsequent in-hospital complications (such as rebleeding, delayed cerebral ischemia, hydrocephalus, and infections), and the relationship of these processes with micro- and macrostructural brain injury, disability, and cognitive impairment.

His work was published in >100 publications and to date (December 2018) has been cited >3500 times.

Mervyn Vergouwen is the president-elect of the 15th International Conference on SubArachnoid Hemorrhage (ISAH) 2019 and co-PI of the Prospective Randomized Open-label Trial to Evaluate risk faCTor management in patients with Unruptured intracranial aneurysms (PROTECT-U).

Research line

Unruptured intracranial aneurysms - Subarachnoid hemorrhage

Most recent key publications

1: Backes D, Rinkel GJ, Greving JP, Velthuis BK, Murayama Y, Takao H, Ishibashi T, Igase M, terBrugge KG, Agid R, Jääskeläinen JE, Lindgren AE, Koivisto T, von und zu Fraunberg M, Matsubara S, Moroi J, Wong GK, Abrigo JM, Igase K, Matsumoto K, Wermer MJ, van Walderveen MA, Algra A, Vergouwen MD. The ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms. Neurology 2017; Mar 31. [Epub ahead of print].

2: Backes D, Rinkel GJ, Laban KG, Algra A, Vergouwen MD. Patient- and aneurysm-specific risk factors for intracranial aneurysm growth - a systematic review and meta-analysis. Stroke 2016;47:951-957.

3: Vergouwen MD, Jong-Tjien-Fa A, Algra A, Rinkel GJ. Time trends in causes of death after aneurysmal subarachnoid hemorrhage: a hospital-based study. Neurology 2016;86:59-63.

4: Etminan N, Brown RD, Beseoglu K, Juvela S, Raymond J, Morita A, Torner JC, Derdeyn CP, Raabe A, Mocco J, Korja M, Abdulazim A, Amin-Hanjani S, Salman RA, Barrow DL, Bederson J, Bonafe A, Dumont A, Fiorella DH, Gruber A, Hankey G, Hasan DM, Hoh BL, Jabbour P, Kasuya H., Kelly ME, Kirkpatrick PJ, Knuckey N, Koivisto T, Krings T, Lawton MT, Marotta TR, Mayer SA, Mee E, Molyneux A, Morgan MK, Mori K, Murayama Y, Nagahiro S, Nakayama N, Niemelä M, Knuckey N, Ogilvy CS, Mendes-Perreira V, Pierot L, Rabinstein AA, Roos YB, Rinne J, Rosenwasser RH, Ronkainen A, Schaller K, Seifert V, Solomon RA, Spears J, Steiger HJ, Vergouwen MD, Wanke I, Wermer MJH, Wong GK, Wong JH, Zipfel GF, Connolly ES, Steinmetz H, Lanzino G, Pasqualin A, Rüfenacht D, LeRoux P, Vajkoczy P, McDougall C, Hänggi D, Rinkel GJ, Macdonald RL. The Unruptured Intracranial Aneurysm Treatment Score: A multidisciplinary consensus. Neurology 2015;85:881-889.  

5: Backes D, Rinkel GJ, van der Schaaf IC, Nij Bijvank JA, Verweij BH, Visser-Meily JM, Post MW, Algra A, Vergouwen MD. Recovery to pre-interventional functioning, return-to-work and life satisfaction after treatment of unruptured aneurysms. Stroke 2015;46:1607-1612.

6: Blok KM, Rinkel GJ, Majoie CB, Hendrikse J, Braaksma M, Tijssen CC, Wong YY, Hofmeijer J, Extercatte J, Kerklaan B, Schreuder TH, ten Holter S, Verheul F, Harlaar L, Pruissen MO, Kwa VI, Brouwers PJ, Remmers MJ, Schonewille WJ, Kruyt ND, Vergouwen MD. CT within 6 hours to rule out subarachnoid hemorrhage in nonacademic hospitals. Neurology 2015;84:1927-1932.

7: Backes D, Vergouwen MD, Velthuis BK, van der Schaaf IC, Bor AS, Algra A, Rinkel GJ. Difference in characteristics between ruptured and unruptured aneurysms in patients with multiple intracranial aneurysms. Stroke 2014;45:1299-1303.

8: Cremers CH, van der Schaaf IC, Wensink E, Greving JP, Rinkel GJ, Velthuis BK, Vergouwen MD. CT perfusion and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Cereb Blood Flow Metab 2014;34:200-207.

9: Backes D, Rinkel GJ, Kemperman H, Linn FH, Vergouwen MD. Time-dependent test characteristics of head CT in patients suspected of non-traumatic subarachnoid hemorrhage. Stroke 2012;43:2115-2119.

10: Diringer MN, Bleck TP, Claude Hemphill J 3rd, Menon D, Shutter L, Vespa P, Bruder N, Connolly ES Jr, Citerio G, Gress D, Hänggi D, Hoh BL, Lanzino G, Le Roux P, Rabinstein A, Schmutzhard E, Stocchetti N, Suarez JI, Treggiari M, Tseng MY, Vergouwen MD, Wolf S, Zipfel G. Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society’s Multidisciplinary Consensus Conference. Neurocrit Care 2011;15:211-240.

11: Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, Mendelow AD, Juvela S, Yonas H, Terbrugge KG, Macdonald RL, Diringer MN, Broderick JP, Dreier JP, Roos YB. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies - Proposal of a multidisciplinary research group. Stroke 2010;41:2391-2395.

12: Vergouwen MD, Meijers JC, Geskus RB, Coert BA, Horn J, Stroes ES, van der Poll T, Vermeulen M, Roos YB. Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage - a double-blind, placebo-controlled randomized trial. J Cereb Blood Flow Metab 2009;29:1444-1453.

13: Vergouwen MD, Vermeulen M, Coert BA, Stroes ES, Roos YB. Microthrombosis after aneurysmal subarachnoid hemorrhage - an additional explanation for delayed cerebral ischemia. J Cereb Blood Flow Metab 2008;28:1761-1770.

14: Vergouwen MD, Vermeulen M, Roos YB. Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage - a systematic review. Lancet Neurol 2006;5:1029-1032.

Fellowship and Awards

1: Jacob Jongbloed Talent Society (2014)
2: Netherlands Heart Foundation Dr. E. Dekker postdoc personal grant (2011)
3: Niels Stensen award for stroke fellowship in Toronto, Canada (2009)

Research Output (161)

Relationship between 3D Morphologic Change and 2D and 3D Growth of Unruptured Intracranial Aneurysms

Timmins Kimberley, Kuijf Hugo, Vergouwen Mervyn, Ruigrok Ynte, Velthuis Birgitta, van der Schaaf Irene Mar 2022, In: American Journal of Neuroradiology. 43 , p. 416-421 6 p.

Time trends in the risk of delayed cerebral ischemia after subarachnoid hemorrhage:a meta-analysis of randomized controlled trials

Rigante Luigi, van Lieshout Jasper Hans, Vergouwen Mervyn D I, van Griensven Carlijn H S, Vart Priya, van der Loo Lars, de Vries Joost, Vinke Ruben Saman, Etminan Nima, Aquarius Rene, Gruber Andreas, Mocco J, Welch Babu G, Menovsky Tomas, Klijn Catharina J M, Bartels Ronald H M A, Germans Menno R, Hänggi Daniel, Boogaarts Hieronymus D Mar 2022, In: Neurosurgical Focus. 52 , p. 1-5

Rebleeding After Aneurysmal Subarachnoid Hemorrhage in Two Centers Using Different Blood Pressure Management Strategies

Calviere Lionel, Gathier Celine, Rafiq Marie, Koopman Inez, Rousseau Vanessa, Raposo Nicolas, Albucher Jean François, Viguier Alain, Geeraerts Thomas, Cognard Christophe, Rinkel Gabriel J E, Vergouwen Mervyn D I, Olivot Jean-Marc 2022, In: Frontiers in Neurology. 13

Reliability and Agreement of 2D and 3D Measurements on MRAs for Growth Assessment of Unruptured Intracranial Aneurysms

Timmins Kimberley, Kuijf Hugo, Vergouwen Mervyn, Otten Maarten, Ruigrok Ynte, Velthuis BK, van der Schaaf Irene 1 Sep 2021, In: American Journal of Neuroradiology. 42 , p. 1598-1603 6 p.

Rescue therapy for vasospasm following aneurysmal subarachnoid hemorrhage:a propensity score-matched analysis with machine learning

Martini Michael L, Neifert Sean N, Shuman William H, Chapman Emily K, Schüpper Alexander J, Oermann Eric K, Mocco J, Todd Michael, Torner James C, Molyneux Andrew, Mayer Stephan, Roux Peter Le, Vergouwen Mervyn D I, Rinkel Gabriel J E, Wong George K C, Kirkpatrick Peter, Quinn Audrey, Hänggi Daniel, Etminan Nima, van den Bergh Walter M, Jaja Blessing N R, Cusimano Michael, Schweizer Tom A, Suarez Jose I, Fukuda Hitoshi, Yamagata Sen, Lo Benjamin, Leonardo de Oliveira Manoel Airton, Boogaarts Hieronymus D, Macdonald R Loch, 2 Jul 2021, In: Journal of Neurosurgery. 136 , p. 134-147 14 p.

Management decisions on unruptured intracranial aneurysms before and after implementation of the PHASES score

Hollands Laurie J., Vergouwen Mervyn D.I., Greving Jacoba P., Wermer Marieke J.H., Rinkel Gabriël J.E., Algra Annemijn M. 15 Mar 2021, In: Journal of the Neurological Sciences. 422

International practice variability in treatment of aneurysmal subarachnoid hemorrhage

de Winkel Jordi, van der Jagt Mathieu, Lingsma Hester F., Roozenbeek Bob, Calvillo Eusebia, Chou Sherry H.Y., Dziedzic Peter H., Etminan Nima, Huang Judy, Ko Nerissa U., Macdonald Robert Loch, Martin Renee L., Potu Niteesh R., Venkatasubba Rao Chethan P., Vergouwen Mervyn D.I., Suarez Jose I. 14 Feb 2021, In: Journal of Clinical medicine. 10 , p. 1-14 14 p.

Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA):a randomised controlled trial

Post René, Germans Menno R., Tjerkstra Maud A., Vergouwen Mervyn D.I., Jellema Korné, Koot Radboud W., Kruyt Nyika D., Willems Peter W.A., Wolfs Jasper F.C., de Beer Frits C., Kieft Hans, Nanda Dharmin, van der Pol Bram, Roks Gerwin, de Beer Frank, Halkes Patricia H.A., Reichman Loes J.A., Brouwers Paul J.A.M., van den Berg-Vos Renske M., Kwa Vincent I.H., van der Ree Taco C., Bronner Irene, van de Vlekkert Janneke, Bienfait Henri P., Boogaarts Hieronymus D., Klijn Catharina J.M., van den Berg René, Coert Bert A., Horn Janneke, Majoie Charles B.L.M., Rinkel Gabriël J.E., Roos Yvo B.W.E.M., Vandertop W. Peter, Verbaan Dagmar, 9 Jan 2021, In: Lancet (London, England). 397 , p. 112-118 7 p.

Risk of Rupture After Intracranial Aneurysm Growth

van der Kamp Laura T, Rinkel Gabriel J E, Verbaan Dagmar, van den Berg René, Vandertop W Peter, Murayama Yuichi, Ishibashi Toshihiro, Lindgren Antti, Koivisto Timo, Teo Mario, St George Jerome, Agid Ronit, Radovanovic Ivan, Moroi Junta, Igase Keiji, van den Wijngaard Ido R, Rahi Melissa, Rinne Jaakko, Kuhmonen Johanna, Boogaarts Hieronymus D, Wong George K C, Abrigo Jill M, Morita Akio, Shiokawa Yoshiaki, Hackenberg Katharina A M, Etminan Nima, van der Schaaf Irene C, Zuithoff Nicolaas P A, Vergouwen Mervyn D I 2021, In: JAMA Neurology. 78 , p. 1228-1235 8 p.

Deferred Consent in an Acute Stroke Trial from a Patient, Proxy, and Physician Perspective:A Cross-Sectional Survey

Koopman Inez, Verbaan Dagmar, Vandertop W Peter, van der Graaf Rieke, Kompanje Erwin J O, Post René, Coert Bert A, Ploem Martine C, Sluis Wouter M, Scheijmans Féline E V, Rinkel Gabriel J E, Vergouwen Mervyn D I 2021, In: Neurocritical Care. 36 , p. 621-629 9 p.

All research output

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