dr. X.Y.Y. Santvoort

dr. X.Y.Y. Santvoort

Full Professor
dr. X.Y.Y. Santvoort
  • Center for Translational Immunology (CTI) Research
  • Department of Hematology



Prof. Dr. Jürgen Kuball received his medical degree as hematologists at the University of Mainz, Germany, and was further trained at the Fred Hutchinson Cancer Center in Seattle, WA, USA. Prof. Kuball joined the Department of Hematology at the University Medical Center in Utrecht in The Netherlands in 2007 as hematologists and immunologist. He became a VIDI-laureate in 2010 and chairs the section applied & tumor-immunology within the laboratory of translation immunology. Since 2013 he is chairing the Department of Hematology (adults). His clinical activities are focusing on treating patients with hematological malignancies including stem cell transplantation. His clinical-translational efforts and patient care are driven by his role as Director of the Bone Marrow Transplantation Program at the University Medical Center Utrecht, as well as active membership of the leukemia working party and stem cell working party of HOVON. His current laboratory activities are focusing on the understanding of innate immune cells and their receptors to recognize malignant cells and virally infected cells as well as the genetic engineering of a transplant.

Side Activities

Board activities

  • EBMT Chair Legal and Regulatory Affairs Committee 2019-
  • HOVON General board 2014-
  • KWF PPS commissie 2022-
  • KWF adviesraad  2016-2022
  • Wetenschappelijke raad KIKA 2018-2021

Translational Valorisation

  • Cofounder and shareholder of Gadeta  2015-
  • Patent holder on multipe inventions  licensed to Gadeta and Miltenyi Biotech  2012-
  • Receiving revenues from licensed patents in the field of genetic engineering 2021-


  • ASH
  • EBMT
  • EHA Member
  • HOVON Leukemia working party
  • HOVON SCT working party 

External positions

  • Scientific advisor, GADETA, 2018 → 2020
  • Scientific Advisory Board, JAZZ pharmaceuticals, 11 Sep 2016
  • Scientific cofounder and CSO, GADETA, 2015 → 2018
  • Shareholder, GADETA, 2015 → …
  • Grant Support, speaker and joint patent application, Miltenyi Biotec, 2015 → …
  • Grant and Scientific advisory board, Novartis, 2015 → …

Fellowship and Awards

American Association of Cancer Research-GlaxoSmithKline Scholar in Cancer Research Award (2001)
Stipendiat der Deutschen Krebshilfe (2005-2007)
Team Science recognition award of the „Society for Immunotherapy of Cancer“ to Jürgen Kuball and the University of Washington, USA (2010)
VIDI-Laureate ZonMW, The Netherlands (2010)

Research Output (185)

The Role of γδ T Cells as a Line of Defense in Viral Infections after Allogeneic Stem Cell Transplantation:Opportunities and Challenges

Janssen Anke, van Diest Eline, Vyborova Anna, Schrier Lenneke, Bruns Anke, Sebestyen Zsolt, Straetemans Trudy, de Witte Moniek, Kuball Jürgen Jan 2022, In: Viruses. 14 , p. 1-15

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Wachsmann Tassilo L A, Wouters Anne K, Remst Dennis F G, Hagedoorn Renate S, Meeuwsen Miranda H, van Diest Eline, Leusen Jeanette, Kuball Jürgen, Falkenburg J H Frederik, Heemskerk Mirjam H M 2022, In: OncoImmunology. 11

Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia

Cornelissen Loes L, Kreuger Aukje L, Caram-Deelder Camila, Huisman Menno V, Middelburg Rutger A, Kerkhoffs Jean Louis H, von dem Borne Peter A, Beckers Erik A M, de Vooght Karen M K, Kuball Jürgen, van der Bom Johanna G, Zwaginga J J 19 Dec 2021, In: European Journal of Haematology. 108 , p. 310-318 9 p.

Vaccine responses in adult hematopoietic stem cell transplant recipients:A comprehensive review

Janssen Michelle, Bruns Anke, Kuball Jürgen, Raijmakers Reinier, van Baarle Debbie 6 Dec 2021, In: Cancers. 13 , p. 1-18

Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Van Diest Eline, Hernández López Patricia, Meringa Angelo D., Vyborova Anna, Karaiskaki Froso, Heijhuurs Sabine, Gumathi Bormin Jan, Van Dooremalen Sanne, Nicolasen Mara J.T., Gatti Lucrezia C.D.E., Johanna Inez, Straetemans Trudy, Sebestyén Zsolt, Beringer Dennis X., Kuball Jürgen 23 Nov 2021, In: Journal for ImmunoTherapy of Cancer. 9 , p. 1-15

Adding Help to an HLA-A*24:02 Tumor-Reactive gamma delta TCR Increases Tumor Control

Johanna Inez, Hernández-López Patricia, Heijhuurs Sabine, Scheper Wouter, Bongiovanni Laura, de Bruin Alain, Beringer Dennis X., Oostvogels Rimke, Straetemans Trudy, Sebestyen Zsolt, Kuball Jürgen 25 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-12

CAR-T cells:comment le registre de l'EBMT monitore les activités en Europe, identifie les contraintes et prépare l’évolution des régulations

Chabannon Christian, Lemaitre Jessica, Peffault de Latour Régis, Neven Bénédicte, Bay Jacques Olivier, Robin Marie, Kuball Jurgen, Terwel Sofie, Mohty Mohamad, Yakoub-Agha Ibrahim Oct 2021, In: BULLETIN DU CANCER. 108 , p. S155-S161 7 p.

Characterization and modulation of anti-alpha beta TCR antibodies and their respective binding sites at the beta TCR chain to enrich engineered T cells

Kierkels Guido J J, van Diest Eline, Hernández-López Patricia, Scheper Wouter, de Bruin Anja C M, Frijlink Elselien, Aarts-Riemens Tineke, van Dooremalen Sanne F J, Beringer Dennis X, Oostvogels Rimke, Kramer Lovro, Straetemans Trudy, Uckert Wolfgang, Sebestyén Zsolt, Kuball Jürgen 10 Sep 2021, In: Molecular Therapy - Methods and Clinical Development. 22 , p. 388-400 13 p.

Efficient lentiviral transduction method to gene modify cord blood CD8<sup>+</sup> T cells for cancer therapy applications

Lo Presti Vania, Cornel Annelisa M., Plantinga Maud, Dünnebach Ester, Kuball Jurgen, Boelens Jaap Jan, Nierkens Stefan, van Til Niek P. 11 Jun 2021, In: Molecular Therapy - Methods and Clinical Development. 21 , p. 357-368 12 p.

Allogeneic hematopoietic cell transplantation with cord blood versus mismatched unrelated donor with post-transplant cyclophosphamide in acute myeloid leukemia

Dholaria Bhagirathbhai, Labopin Myriam, Sanz Jaime, Ruggeri Annalisa, Cornelissen Jan, Labussière-Wallet Hélène, Blaise Didier, Forcade Edouard, Chevallier Patrice, Grassi Anna, Zubarovskaya Ludmila, Kuball Jürgen, Ceballos Patrice, Ciceri Fabio, Baron Frederic, Savani Bipin N, Nagler Arnon, Mohty Mohamad 3 May 2021, In: Journal of hematology & oncology. 14

All research output

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