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drs. R.S.S. (Wigard) Meijering

drs. R.S.S. (Wigard) Meijering

Associate Professor
drs. R.S.S. (Wigard) Meijering
  • Group De Ridder, section Genetics

Research Output (91)

Distinct Genomic Profiles Are Associated with Treatment Response and Survival in Ovarian Cancer

de Witte Chris J, Kutzera Joachim, van Hoeck Arne, Nguyen Luan, Boere Ingrid A, Jalving Mathilde, Ottevanger Petronella B, van Schaik-van de Mheen Christa, Stevense Marion, Kloosterman Wigard P, Zweemer Ronald P, Cuppen Edwin, Witteveen Petronella O 2 Mar 2022, In: Cancers. 14 , p. 1-18

Accurate detection of circulating tumor DNA using nanopore consensus sequencing

Marcozzi Alessio, Jager Myrthe, Elferink Martin, Straver Roy, van Ginkel Joost H, Peltenburg Boris, Chen Li-Ting, Renkens Ivo, van Kuik Joyce, Terhaard Chris, de Bree Remco, Devriese Lot A, Willems Stefan M, Kloosterman Wigard P, de Ridder Jeroen 9 Dec 2021, In: npj Genomic Medicine. 6 , p. 1-11

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Bollen Yannik, Stelloo Ellen, van Leenen Petra, van den Bos Myrna, Ponsioen Bas, Lu Bingxin, van Roosmalen Markus J., Bolhaqueiro Ana C.F., Kimberley Christopher, Mossner Maximilian, Cross William C.H., Besselink Nicolle J.M., van der Roest Bastiaan, Boymans Sander, Oost Koen C., de Vries Sippe G., Rehmann Holger, Cuppen Edwin, Lens Susanne M.A., Kops Geert J.P.L., Kloosterman Wigard P., Terstappen Leon W.M.M., Barnes Chris P., Sottoriva Andrea, Graham Trevor A., Snippert Hugo J.G. 2021, In: Nature Genetics. 53 , p. 1187-1195 9 p.

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte Chris Jenske, Espejo Valle-Inclan Jose, Hami Nizar, Lõhmussaar Kadi, Kopper Oded, Vreuls Celien Philomena Henrieke, Jonges Geertruida Nellie, van Diest Paul, Nguyen Luan, Clevers Hans, Kloosterman Wigard Pieter, Cuppen Edwin, Snippert Hugo Johannes Gerhardus, Zweemer Ronald Peter, Witteveen Petronella Oda, Stelloo Ellen 16 Jun 2020, In: Cell Reports. 31 8 p.

Multi-contact 4C:long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies

Vermeulen Carlo, Allahyar Amin, Bouwman Britta A.M., Krijger Peter H.L., Verstegen Marjon J.A.M., Geeven Geert, Valdes-Quezada Christian, Renkens Ivo, Straver Roy, Kloosterman Wigard P., de Ridder Jeroen, de Laat Wouter 1 Feb 2020, In: Nature Protocols. 15 , p. 364-397 34 p.

Prioritization of genes driving congenital phenotypes of patients with de novo genomic structural variants

Middelkamp Sjors, Vlaar Judith M, Giltay Jacques, Korzelius Jerome, Besselink Nicolle, Boymans Sander, Janssen Roel, de la Fonteijne Lisanne, van Binsbergen Ellen, van Roosmalen Markus J, Hochstenbach Ron, Giachino Daniela, Talkowski Michael E, Kloosterman Wigard P, Cuppen Edwin 4 Dec 2019, In: Genome Medicine. 11

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Nersisyan Lilit, Nikoghosyan Maria, Arakelyan Arsen, Francioli Laurent C., Menelaou Androniki, Pulit Sara L., Elbers Clara C., Kloosterman Wigard P., van Setten Jessica, Nijman Isaäc J., Renkens Ivo, de Bakker Paul I.W., van Dijk Freerk, Neerincx Pieter B.T., Deelen Patrick, Kanterakis Alexandros, Dijkstra Martijn, Byelas Heorhiy, van der Velde K. Joeri, Platteel Mathieu, Swertz Morris A., Wijmenga Cisca, Palamara Pier Francesco, Pe’er Itsik, Ye Kai, Ye Kai, Lameijer Eric Wubbo, Moed Matthijs H., Beekman Marian, de Craen Anton J.M., Suchiman H. Eka D., Slagboom P. Eline, Guryev Victor, Abdellaoui Abdel, Jan Hottenga Jouke, Kattenberg Mathijs, Willemsen Gonneke, Boomsma Dorret I., van Leeuwen Elisabeth M., Karssen Lennart C., Amin Najaf, Rivadeneira Fernando, Isaacs Aaron, Hofman Albert, Uitterlinden André G., van Duijn Cornelia M., van Oven Mannis, Kayser Manfred, Veldink Jan H., van den Berg Leonard H., 1 Dec 2019, In: Scientific Reports. 9

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

Kneissig M, Keuper K, de Pagter Mirjam, van Roosmalen Mark, Martin J, Otto H, Passerini V, Campos Sparr A, Renkens Ivo , Kropveld F, Vasudevan A, Sheltzer JM, Kloosterman Wigard, Storchova Zuzana 28 Nov 2019, In: eLife. 8

Detection of disease causing repeats by multi-locus CRISPR-Cas enrichment and nanopore sequencing

Elferink M. G., Renkens I. J., Dooijes D., van Roosmalen M. J., Raimondeau E., Bowen R., Heron A. J., Graham J. E., van Amstel H. Ploos, Kloosterman W. P., van Gassen K. L. Oct 2019, In: European Journal of Human Genetics. 27 , p. 1658-1658

Detection of disease causing repeats by multi-locus CRISPR-Cas enrichment and nanopore sequencing

Elferink Martin, Renkens Ivo , Dooijes Dennis, van Roosmalen Mark, Ploos van Amstel Hans Kristian, Kloosterman Wigard, van Gassen Koen 16 Jun 2019,

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