dr. L.M.M. (Folkert) Lenferink

dr. L.M.M. (Folkert) Lenferink

Full Professor
dr. L.M.M. (Folkert) Lenferink
  • Division of Heart & Lungs

Research Programs

Circulatory Health



Prof Dr. Folkert W. Asselbergs is Professor of Precision medicine at Institute of Health Informatics and the institute of Cardiovasculair Science, University College London, Director of the NIHR BRC UCL/UCLH Clinical and Research Informatics Unit, consultant cardiologist and Professor of Precision Medicine at University Medical Center Utrecht, University of Utrecht, the Netherlands, associate editor European Heart Journal, section digital health and innovation, Chair Center for Circulatory Health, UMC Utrecht, and chair data infrastructure Dutch Cardiovascular Alliance ( 


Professor Asselbergs published more than 500 scientific papers in the field of cardiovascular disease and his work has been funded by the Netherlands Heart Foundation, Netherlands Heart Institute, British Heart Foundation, leDucq Foundation, EU FP7, European Society of Cardiology, BBMRI, National Institutes of Health, Innovative Medicines Initiative, European Research Area Network on Cardiovascular Diseases and ZonMw.


His research program in complex genetics focuses on the discovery of genes influencing susceptibility to cardiovascular disease; the application of these findings for the validation of drug targets; and the use of genetic tests for treatment targeting (stratified medicine). Lately, he widened his research focus to precision medicine using linked data sources such as wearable information and routine care data obtained from electronic health records including free text. His ambition is to build a network for performing clinical trials within routine health care linked to national registries. 


Prof Asselbergs is member of a large number of consortia and (co-) founded several consortia of which igenetrain (, and GENIUS-CHD (, and CAPACITY-COVID (  are the most prominent and recent ones. He is scientific coordinator of European IMI Bigdate@heart consortium ( Bigdata@heart aims to deliver clinically relevant disease cardiovascular phenotypes, scalable insights from real-world evidence including data from registries, wearables and electronic health records, and insight driving drug development and personalized medicine through advanced big-data analytics. 


Side Activities

  • Prof of Precision medicine at the Institute of Cardiovascular Science and Institute of Health Informatics, University College London
  • Director NIHR BRC Clinical Research Informatics Unit, University College London Hospital
  • Chair Center for Circulatory Health, UMC Utrecht
  • Chair data infrastructure Dutch Cardiovascular Alliance (
  • Associate editor European Heart Journal, section Digital Health and Innovation

Fellowship and Awards

2003 Dr. E. Dekker Scholarship of the Dutch Heart Foundation (2003T010).
2005 Scholarship Netherlands Heart Institute for postdoc Harvard School of public health
2007 Netherlands Foundation of CardioVascular Excellence grant
2010 Clinical fellowship from the Netherlands Organisation for Health Research (ZonMw grant 90700342),
2012 European Society of Cardiology Training grant (T2012-006).
2013 Fellow European Society of Cardiology
2014 Dr. E. Dekker Scholarship of the Dutch Heart Foundation (2014T001)
2019 Scholarship European Society of Cardiology Executive Master Health Economics at LSE
2021 Pearl award ZonMw, Netherlands:

Research Output (456)

Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events

van den Berg Victor J, Vroegindewey Maxime M, Umans Victor A, van der Harst Pim, Asselbergs Folkert W, Akkerhuis K Martijn, Kardys Isabella, Boersma Eric, 2 Feb 2022, In: Biomarkers. 27 , p. 264-269 6 p.

Reply to the Letter to the Editor: "It is urgent to evaluate the efficacy and safety of genotype guided antiplatelet therapy in patients after percutaneous coronary intervention in East Asian"

Al-Rubaish Abdullah M, Al-Muhanna Fahad A, Alshehri Abdullah M, Al-Mansori Mohammed A, Alali Rudaynah A, Khalil Rania M, Al-Faraidy Khalid A, Cyrus Cyril, Sulieman Mohammed M, Vatte Chittibabu, Loza Bao-Li, Claassens Daniel M F, Asselbergs Folkert W, Al-Ali Amein K 1 Feb 2022, In: International Journal of Cardiology. 348 , p. 57 1 p.

Less loop diuretic use in patients on sacubitril/valsartan undergoing remote pulmonary artery pressure monitoring

Böhm Michael, Assmus Birgit, Anker Stefan D, Asselbergs Folkert W, Brachmann Johannes, Brett Marie-Elena, Brugts Jasper J, Ertl Georg, Wang AiJia, Hilker Lutz, Koehler Friedrich, Rosenkranz Stephan, Leistner David M, Abdin Amr, Wintrich Jan, Zhou Qian, Adamson Philip B, Angermann Christiane E Feb 2022, In: ESC heart failure. 9 , p. 155-163 9 p.

Relation of Iron Status to Prognosis After Acute Coronary Syndrome

Gürgöze Muhammed T, Kardys Isabella, Akkerhuis K Martijn, Oemrawsingh Rohit M, Groot Hilde E, van der Harst Pim, Umans Victor A, Kietselaer Bas, Ronner Eelko, Lenderink Timo, Asselbergs Folkert W, Manintveld Olivier C, Boersma Eric 16 Jan 2022, In: The American Journal of Cardiology. 168 , p. 22-30 9 p.

Sex disparity in subsequent outcomes in survivors of coronary heart disease

Akyea Ralph Kwame, Kontopantelis Evangelos, Kai Joe, Weng Stephen F., Patel Riyaz S., Asselbergs Folkert W., Qureshi Nadeem 1 Jan 2022, In: Heart (British Cardiac Society). 108 , p. 37-45 9 p.

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Slenders Lotte, Landsmeer Lennart P L, Cui Kai, Depuydt Marie A C, Verwer Maarten, Mekke Joost, Timmerman Nathalie, van den Dungen Noortje A M, Kuiper Johan, de Winther Menno P J, Prange Koen H M, Ma Wei Feng, Miller Clint L, Aherrahrou Redouane, Civelek Mete, de Borst Gert J, de Kleijn Dominique P V, Asselbergs Folkert W, den Ruijter Hester M, Boltjes Arjan, Pasterkamp Gerard, van der Laan Sander W, Mokry Michal Jan 2022, In: European heart journal open. 2

Chromatin Immunoprecipitation Sequencing (ChIP-seq) Protocol for Small Amounts of Frozen Biobanked Cardiac Tissue

Pei Jiayi, van den Dungen Noortje A M, Asselbergs Folkert W, Mokry Michal, Harakalova Magdalena 2022, 2458 , p. 97-111 15 p.

Cardiovascular risk prediction in type 2 diabetes:a comparison of 22 risk scores in primary care settings

Dziopa Katarzyna, Asselbergs Folkert W., Gratton Jasmine, Chaturvedi Nishi, Schmidt Amand F. 2022, In: Diabetologia. 65 , p. 644-656 13 p.

A population-based study of 92 clinically recognized risk factors for heart failure:co-occurrence, prognosis and preventive potential

Banerjee Amitava, Pasea Laura, Chung Sheng-Chia, Direk Kenan, Asselbergs Folkert, Grobbee Diederick E, Kotecha Dipak, Anker Stefan D, Dyszynski Tomasz, Tyl Benoît, Denaxas Spiros, Lumbers R Thomas, Hemingway Harry 30 Dec 2021, In: European Journal of Heart Failure. 24 , p. 466-480 15 p.

Methodological issues in meta-analyses of real-world clinical data to infer causality

Uijl Alicia, Lund Lars H, Asselbergs Folkert W, Savarese Gianluigi 15 Dec 2021, In: International Journal of Cardiology. 345 , p. 107-108 2 p.

All research output

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