drs. U.V.V. (Frank ) Kreek

drs. U.V.V. (Frank ) Kreek

Full Professor
drs. U.V.V. (Frank ) Kreek
  • Internal Medicine

Research Programs

Circulatory Health



Frank Visseren (1965) is Internist, Epidemiologist and Professor in Vascular Medicine at the University Medical Center in Utrecht. He is head of the Department of Vascular Medicine and responsible for patient care, research, and teaching. The Department of Vascular Medicine at the UMC Utrecht consists of Internists, Fellows, Research Nurses and PhD students. His main research interest is in the field of insulin resistance and vascular diseases and consists of basic, translational and epidemiologic research covering etiology, therapy, prognosis and diagnosis. There is a focus on (visceral) adipose tissue and development of atherosclerosis, atherotrombosis and diabetes. An other research focus is on translating the results of large clinical trials to invidivual patients, in collaboration with (inter)national partners. He is (co-)author of over 300 publications and associate editor of 2 scientific journals. The GCP certified research unit of the Department of Vascular Medicine performs state-of-the-art non-invasive vascular imaging tests including FMD, FBF, PWV, fingertip plethysmography, IMT and HRV. There is broad experience with industry-sponsored clinical trials in the field of Vascular Medicine, Cardiology and Diabetology and he also serves as sponsor of multi-national investigator initiated studies. He is the clinical director of the Second Manifestations of ARTerial disease (SMART) cohort at the UMC Utrecht. This is a cohort with over 13,000 patients with vascular diseases and/or type 2 diabetes or severe hypertension or familial hyperlipidemia, growing with 800 patients annually, for etiologic, prognostic, diagnostic and therapeutic research. He was (co-)supervisor of 30 thesis and currently involved in the supervision of 11  PhD students.

The clinical work of the Department of Vascular Medicine is concentrated around patients at high risk for the development of cardiovascular diseases including patients with Familial Hypercholesterolemia, patients with therapy-resistant hypertension and patients with diabetes and vascular disease. He strongly believes in a multidisciplinary, patient-centered approach in the treatment of patients at high risk for the development of (new) vascular diseases.

Teaching covers first year Medical Students to clinical specialty training in Vascular Medicine. He is member of the Concilium Medicinae Internae and chairman of the section Vascular Medicine of the Dutch Internal Medicine Society.

Side Activities

Chairman ESC 2021 Cardiovascular Prevention Guideline Task Force (2019-2021)

Member board Vascular Medicine, Dutch Internal Medicine Association (NIV) (2006- ongoing)

Member National guideline committee Cardio Vascular Risk Management (CVRM) (2016-2019, 2021- ongoing)

Member National guideline committee addendum CVRM for elderly (2015-2019)

Member National guideline committee addendum (Genetic) Dyslipidemia (2015-2019)

Chairman ‘Writing committee Facts & Figures’ (Commissie Cijfers) Dutch Heart Foundation (2009-2020)

Research Output (516)

Chronic kidney disease and atrial fibrillation:A dangerous combination

Ocak Gurbey, Khairoun Meriem, Khairoun Othman, Bos Willem Jan W, Fu Edouard L, Cramer Maarten J, Westerink Jan, Verhaar Marianne C, Visseren Frank L, Apr 2022, In: PLoS ONE. 17 , p. 1-13

The relation between urinary sodium and potassium excretion and risk of cardiovascular events and mortality in patients with cardiovascular disease

Groenland Eline H., Vendeville Jean Paul, Bots Michiel L., de Borst Gert Jan, Nathoe Hendrik M., Ruigrok Ynte M., Blankestijn Peter J., Visseren Frank L.J., Spiering Wilko Mar 2022, In: PLoS ONE. 17

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

Visseren Frank L J, Mach François, Smulders Yvo M, Carballo David, Koskinas Konstantinos C, Bäck Maria, Benetos Athanase, Biffi Alessandro, Boavida José-Manuel, Capodanno Davide, Cosyns Bernard, Crawford Carolyn, Davos Constantinos H, Desormais Ileana, Di Angelantonio Emanuele, Franco Oscar H, Halvorsen Sigrun, Hobbs F D Richard, Hollander Monika, Jankowska Ewa A, Michal Matthias, Sacco Simona, Sattar Naveed, Tokgozoglu Lale, Tonstad Serena, Tsioufis Konstantinos P, van Dis Ineke, van Gelder Isabelle C, Wanner Christoph, Williams Bryan, 19 Feb 2022, In: European Journal of Preventive Cardiology. 29 , p. 5-115 111 p.

Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease:the updated SMART2 algorithm

Hageman Steven H J, McKay Ailsa J, Ueda Peter, Gunn Laura H, Jernberg Tomas, Hagström Emil, Bhatt Deepak L, Steg Ph Gabriel, Läll Kristi, Mägi Reedik, Nordbø Gynnild Mari, Ellekjær Hanne, Saltvedt Ingvild, Tuñón José, Mahíllo Ignacio, Aceña Álvaro, Kaminski Karol, Chlabicz Malgorzata, Sawicka Emilia, Tillman Taavi, McEvoy John W, Di Angelantonio Emanuele, Graham Ian, De Bacquer Dirk, Ray Kausik K, Dorresteijn Jannick A N, Visseren Frank L J, 15 Feb 2022, In: European heart journal. 43 , p. 1715-1727 13 p.

The 'ten commandments' for the 2021 ESC Guidelines on CVD prevention

Carballo David, Visseren Frank L.J., Mach François, Smulders Yvo 25 Jan 2022, In: European heart journal. 43 , p. 174-176 3 p.

Population median imputation was noninferior to complex approaches for imputing missing values in cardiovascular prediction models in clinical practice

Berkelmans G F N, Read S H, Gudbjörnsdottir S, Wild S H, Franzen S, van der Graaf Y, Eliasson B, Visseren F L J, Paynter N P, Dorresteijn J A N 20 Jan 2022, In: Journal of Clinical Epidemiology. 145 , p. 70-80 11 p.

Impact of a Patient’s Baseline Risk on the Relative Benefit and Harm of a Preventive Treatment Strategy:Applying Trial Results in Clinical Decision Making

de Vries Tamar I., Stam-Slob Manon C., Peters Ron J.G., van der Graaf Yolanda, Westerink Jan, Visseren Frank L.J. 4 Jan 2022, In: Journal of the American Heart Association. 11 , p. 1-17

Risk Factor Clusters and Cardiovascular Disease in High-Risk Patients:The UCC-SMART Study

Holthuis Emily I., Visseren Frank L.J., Bots Michiel L., Peters Sanne A.E. 21 Dec 2021, In: Global Heart. 16 , p. 1-12

Allopurinol to reduce cardiovascular morbidity and mortality:A systematic review and meta-analysis

van der Pol Karel H., Wever Kimberley E., Verbakel Mariette, Visseren Frank L.J., Cornel Jan H., Rongen Gerard A. Dec 2021, In: PLoS ONE. 16 , p. 1-19

Insulin resistance and risk of vascular events, interventions and mortality in type 1 diabetes

Helmink Marga A G, de Vries Marieke, Visseren Frank L J, de Ranitz Wendela L, de Valk Harold W, Westerink Jan 10 Nov 2021, In: European Journal of Endocrinology. 185 , p. 831-840 10 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not