ing. M.N.N. Hoezen

ing. M.N.N. Hoezen

Full Professor
ing. M.N.N. Hoezen

Research Programs




The overall aim of prof. Hendrikse’s research is to understand the cause of ischemic stroke with a focus on the three P’s: Pipes (vessel and vessel walls), Perfusion (CBF and reserve capacity) and Parenchyma (brain tissue and tissue changes/infarcts). After his PhD in 2004 he has created a new research field with technical development and clinical applications of MR methods of cerebral perfusion (so called arterial spin labeling MRI) and intracranial vessel wall imaging. His original MR research is recognized by the international research field with European grants (FP7, Biocog; WP leader) and personal national excellence grants (ERC-StG, VIDI, VENI, Heart association, Technical Research Council), chairmanship of international (ISMRM) perfusion study group, steering committee member of Carotid Stenosis Triallists Collaboration (CSTC), invited lectures, reviews, white papers and book chapters. 22 of his publications are within international collaborations (including Johns Hopkins University and Vanderbilt University, USA). He has over 30 publications within the field of 7T MRI brain imaging method developments. In the radiology and neurovascular research arena ‘RADIOLOGY and ‘STROKE’ are leading journals: he has over 30 publications in these journals. He is the first radiologist awarded with a VIDI grant and an ERC-StG. The focus of his research group is to understand the relation between the ‘3Ps’: pipes (arterial vasculature), perfusion and parenchyma (brain tissue damage) by using innovative imaging methods. Early 2017 he was appointed Chairman of Radiology and Nuclear Medicine UMC Utrecht.


Research line

Brain MRI: Pipes, Perfusion, Parenchyma

Most recent key publications

1: Dieleman N, Van der Kolk AG. Hendrikse J. MR intracranial vessel wall imaging: current prospects and future directions. Circulation. 2014 Jul 8;130(2):192-201
2: De Vis JB, Petersen ET, Bhogal A, Hartkamp NS, Klijn CJ, Kappelle LJ, Hendrikse J. Calibrated MRI to evaluate cerebral hemodynamics in patients with an internal carotid artery occlusion. J Cereb Blood Flow Metab. 2015 Jun;35(6):1015-23
3: Van der Kolk AG, Zwanenburg JJ, Brundel M, Biessels GJ, Visser F, Luijten PR, Hendrikse J. Distribution and natural course of intracranial vessel wall lesions in patients with ischemic stroke or TIA at 7.0 Tesla MRI. Eur Radiol. 2015 Jun;25(6):1692-700
4: De Rotte AA, Truijman MT, van Dijk AC, Liem MI, Schreuder FH, van der Kolk AG, de Kruijk JR, Daemen MJ, van der Steen AF, de Borst GJ, Luijten PR, Nederkoorn PJ, Kooi ME, van der Lugt A, Hendrikse J. Plaque components in symptomatic moderately stenosed carotid arteries related to cerebral infarcts: the plaque at RISK study. Stroke. 2015 Feb;46(2):568-71
5: Hendrikse J, Van der Grond J, Lu H, Van Zijl PCM, Golay X. Flow territory mapping of the cerebral arteries with MRI. Stroke. 2004;35:882-887

Side Activities

ZonMW Veni-subsidiereviewer 2018, 2019, 2020, 2021, 2022

ASNR congres 2022: panel discussion


Fellowship and Awards

1: ERC-StG
2: VENI and VIDI
3: FP7-WP-Leader
4: Dutch Heart Association
5: STW/Technical Research Council

Research Output (328)

Carotid Plaque Characteristics Predict Recurrent Ischemic Stroke and TIA:The PARISK (Plaque At RISK) Study

van Dam-Nolen Dianne H K, Truijman Martine T B, van der Kolk Anja G, Liem Madieke I, Schreuder Floris H B M, Boersma Eric, Daemen Mat J A P, Mess Werner H, van Oostenbrugge Robert J, van der Steen Antonius F W, Bos Daniel, Koudstaal Peter J, Nederkoorn Paul J, Hendrikse Jeroen, van der Lugt Aad, Kooi M Eline, Oct 2022, In: JACC. Cardiovascular imaging. 15 , p. 1715-1726 12 p.

Presurgical diffusion metrics of the thalamus and thalamic nuclei in postoperative delirium:A prospective two-centre cohort study in older patients

Fislage Marinus, Winzeck Stefan, Stamatakis Emmanuel, Correia Marta M, Preller Jacobus, Feinkohl Insa, Spies Claudia D, Hendrikse Jeroen, J C Slooter Arjen, Winterer Georg, Pischon Tobias, Menon David K, Zacharias Norman, 19 Sep 2022, In: NeuroImage. Clinical. 36 , p. 103208

Automatic quantification of perivascular spaces in T2-weighted images at 7 T MRI

Verbeek-Spijkerman Jolanda, Zwanenburg J. J.M., Bouvy W. H., Geerlings M. I., Biessels G. J., Hendrikse J., Luijten P. R., Kuijf H. J. 13 Apr 2022, In: Cerebral Circulation - Cognition and Behavior. 3 , p. 1-9

An anomaly detection approach to identify chronic brain infarcts on MRI

van Hespen Kees M, Zwanenburg Jaco J M, Dankbaar Jan W, Geerlings Mirjam I, Hendrikse Jeroen, Kuijf Hugo J Dec 2021, In: Scientific Reports. 11

The Association Between Time-Varying Wall Shear Stress and the Development of Plaque Ulcerations in Carotid Arteries From the Plaque at Risk Study

Dilba Kristine, van Dam-Nolen Dianne H K, Korteland Suze-Anne, van der Kolk Anja G, Kassem Mohamed, Bos Daniel, Koudstaal Peter J, Nederkoorn Paul J, Hendrikse Jeroen, Kooi M Eline, Gijsen Frank J H, van der Steen Anton F W, van der Lugt Aad, Wentzel Jolanda J 18 Nov 2021, In: Frontiers in cardiovascular medicine. 8

Sensitivity of brain MRI and neurological examination for detection of upper motor neurone degeneration in amyotrophic lateral sclerosis

Nitert Abram D, Tan Harold Hg, Walhout Renée, Knijnenburg Nienke L, van Es Michael A, Veldink Jan H, Hendrikse Jeroen, Westeneng Henk-Jan, van den Berg Leonard H 18 Oct 2021, In: Journal of neurology, neurosurgery, and psychiatry. 93 , p. 82-92 11 p.


Flies C. M., van Leuken K. H., Verhoeff J. J. C., de Vos F. Y. F., Seute T., Robe P. A., Hendrikse J., Witkamp T. D., Dankbaar J. W., Snijders T. J. Sep 2021, In: Neuro-Oncology. 23 , p. ii41-ii41

Dolichoarteriopathies of the extracranial internal carotid artery:The Plaque At RISK study

Dilba Kristine, van Dam-Nolen Dianne H K, Crombag Geneviève A J C, van der Kolk Anja G, Koudstaal Peter J, Nederkoorn Paul J, Hendrikse Jeroen, Kooi Marianne Eline, van der Steen Antonius F W, Wentzel Jolanda J, van der Lugt Aad, Bos Daniel Sep 2021, In: European Journal of Neurology. 28 , p. 3133-3138 6 p.

Association of Ischemic Imaging Phenotype With Progression of Brain Atrophy and Cerebrovascular Lesions on MRI:The SMART-MR Study

Rissanen Ina, Lucci Carlo, Ghaznawi Rashid, Hendrikse Jeroen, Kappelle L. Jaap, Geerlings Mirjam I., , van der Kaaij NP, Asselbergs Folkert 21 Jul 2021, In: Neurology. 97 , p. e1063-e1074

Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery:The Plaque at RISK (PARISK) study

van Dam-Nolen Dianne H K, van Dijk Anouk C, Crombag Geneviève A J C, Lucci Carlo, Kooi M Eline, Hendrikse Jeroen, Nederkoorn Paul J, Daemen Mat J A P, van der Steen Antonius F W, Koudstaal Peter J, Kronenberg Florian, Roeters van Lennep Jeanine E, Mulder Monique T, van der Lugt Aad Jul 2021, In: Atherosclerosis. 329 , p. 22-29 8 p.

All research output

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