prof. dr. D. (Kees) Hilderink

prof. dr. D. (Kees) Hilderink

Full Professor
prof. dr. D. (Kees) Hilderink
  • Neurologen

Research Programs




Kees Braun obtained his Medical Degree at Utrecht University in January 1992. He specialized in Neurology (registered in 2000) and Paediatric Neurology (registered in 2002) in the UMC Utrecht. In 2000 he obtained his PhD degree on a thesis entitled “Magnetic Resonance Spectroscopy in Hydrocephalus. He was appointed as staff neurologist in 2000 and paediatric neurologist in 2002. Since 2011 he is head of Paediatric Neurology/Neurosurgery.  In May 2012 he was appointed as a full professor of Paediatric Neurology.

His clinical and scientific areas of expertise are: refractory paediatric epilepsy, epilepsy surgery,  imaging in epilepsy, and childhood arteriopathic stroke, in particular moyamoya treatment.

He coordinates epilepsy research in the  UMCU Brain center. The epilepsy research projects he is personally involved in  focus on the effects of focal epilepsy on the brain in animal models and patients (structural and functional integrity and network analysis); seizure- and cognitive outcome after paediatric epilepsy surgery; postoperative antiepileptic drug withdrawal; ESES treatment; stress and epilepsy; and epileptic focus detection in surgical candidates.

Kees Braun currently is president of the Dutch Society of Paediatric Neurology and of the organizing committee of the 2016 world congress of child neurology (ICNC) in Amsterdam. He is member of the European Task Force for Epilepsy Surgery in Children (U-Task), the European Network for Epilepsy Research (ENER), and work-package leader of the EU-funded E-PILEPSY project.

Research line

Refractory epilepsy

Most recent key publications

1: Boshuisen K, Arzimanoglou A, Cross JH, Uiterwaal CS, Polster T, van Nieuwenhuizen O, Braun KP; for the TimeToStop study Group. Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study. Lancet Neurol 2012:11:784-791
2: Van Campen JS, Jansen FE, Pet MA, Otte WM, Hillegers MH, Joels M, Braun KP. Relation between stress-precipitated seizures and the stress response in childhood epilepsy. Brain 2015;138:2234-2248
3: Lamberink HJ, Boshuisen K, van Rijen PC, Gosselaar PH, Braun KP. Changing profiles of pediatric epilepsy surgery candidates over time: a nationwide single-center experience from 1990 to 2011. Epilepsia 215;56:717-725
4: Boshuisen K, van Schooneveld MM, Uiterwaal CS, Cross JH, Harrison S, Polster T, Daehn M, Djimjadi S, Yalnizoglu D, Turanli G, Sassen R, Hoppe C, Kuczaty S, Barba C, Kahane P, Schubert-Bast S, Reuner G, Bast T, Strobl K, Mayer H, de Saint-Martin A, Seegmuller C, Laurent A, Arzimanoglou A, Braun KP, for the TimeToStop cognitive outcome study group. Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery. Ann Neurol 2015;78:104-114
5: Braun KPJ, Bulder MMM, Chabrier S, Kirkham FJ, Uiterwaal CSP, Tardieu M, Sebire G. Longitudinal vascular imaging in 79 children with ischemic stroke and unilateral intracranial arteriopathy. Brain 2009;132:544-557

Side Activities

As mentioned in the Biography.

Fellowship and Awards

1: Recipient of the first “Patrick Hanlo Award”, March 17 2009
2: Personal investment grant for epilepsy research by the Dutch National Epilepsy Fund
3: Recipient of the “Gerlach Cerfontaine Fellowship” of the Catharijne Foundation, UMCU, 1998-2000, for the PhD project “Magnetic Resonance Spectroscopy in Hydrocephalus”
4: Recipient of several research grants from e.g. the Dutch Epilepsy Fund, Johanna Children’s Fund, and Wilhelmina Research Fund.

Research Output (256)

Cumulative effects of antiseizure medication on intelligence in children with focal epilepsy

Stevering Carmen H., Lamberink Herm J., Woodfield Julie, van Schooneveld Monique, Otte Willem M., Chin Richard F.M., Bastin Mark E., Geleijns Karin, Braun Kees P.J. 1 Oct 2022, In: Epileptic disorders : international epilepsy journal with videotape. 24 , p. 877-888 12 p.

Association of Early MRI Characteristics With Subsequent Epilepsy and Neurodevelopmental Outcomes in Children With Tuberous Sclerosis Complex

Hulshof Hanna M, Kuijf Hugo J, Kotulska Katarzyna, Curatolo Paolo, Weschke Bernhard, Riney Kate, Krsek Pavel, Feucht Martha, Nabbout Rima, Lagae Lieven, Jansen Anna, Otte Wim M, Lequin Maarten H, Sijko Kamil, Benvenuto Arianna, Hertzberg Christoph, Benova Barbora, Scholl Theresa, De Ridder Jessie, Aronica EleonoraM A, Kwiatkowski David J, Jozwiak Sergiusz, Jurkiewicz Elzbieta, Braun Kees, Jansen Floor E, 31 Jan 2022, In: Neurology. 98 , p. e1216-e1225

High-frequency oscillations in scalp EEG:A systematic review of methodological choices and clinical findings

Noorlag Lotte, van Klink Nicole E.C., Kobayashi Katsuhiro, Gotman Jean, Braun Kees P.J., Zijlmans Maeike 20 Jan 2022, In: Clinical Neurophysiology. 137 , p. 46-58 13 p.

Development and Validation of Prediction Models for Developmental and Intellectual Outcome Following Pediatric Epilepsy Surgery

Cloppenborg Thomas, van Schooneveld Monique, Hagemann Anne, Hopf Johanna Lena, Kalbhenn Thilo, Otte Willem M., Polster Tilman, Bien Christian G., Braun Kees P.J. 18 Jan 2022, In: Neurology. 98 , p. e225-e235

Is the crystal ball broken?:Another external validation of the post-withdrawal seizure-relapse prediction model

Terman Samuel W., Lamberink Herm J., Slinger Geertruida, Otte Willem M., Burke James F., Braun Kees P.J. Dec 2021, In: Epilepsia. 62 , p. 3146-3147 2 p.

The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia

Hulshof Hanna M., Benova Barbora, Krsek Pavel, Kyncl Martin, Lequin Maarten H., Belohlavkova Anezka, Jezdik Petr, Braun Kees P.J., Jansen Floor E. Dec 2021, In: Epilepsia Open. 6 , p. 663-671 9 p.

Comparative Effectiveness of Stereotactic Electroencephalography Versus Subdural Grids in Epilepsy Surgery

Jehi Lara, Morita-Sherman Marcia, Love Thomas E., Bartolomei Fabrice, Bingaman William, Braun Kees, Busch Robyn M., Duncan John, Hader Walter J., Luan Guoming, Rolston John D., Schuele Stephan, Tassi Laura, Vadera Sumeet, Sheikh Shehryar, Najm Imad, Arain Amir, Bingaman Justin, Diehl Beate, de Tisi Jane, Rados Matea, Van Eijsden Pieter, Wahby Sandra, Wang Xiongfei, Wiebe Samuel Dec 2021, In: Annals of Neurology. 90 , p. 927-939 13 p.

An updated systematic review and meta-analysis of brain network organization in focal epilepsy:Looking back and forth

Slinger Geertruida, Otte Willem M, Braun Kees P J, van Diessen Eric 20 Nov 2021, In: Neuroscience and Biobehavioral Reviews. 132 , p. 211-223 13 p.

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse, van Huffelen Alexander, van Klink Nicole, Benders Manon, de Vries Linda, Leijten Frans, Jansen Floor E., Braun Kees, Zijlmans Maeike Nov 2021, In: Epilepsia. 62 , p. 114-115

High-resolution electric source imaging for presurgical evaluation of tuberous sclerosis complex patients

Mouthaan Brian E., Jansen Floor E., Colon Albert J., Huiskamp Geertjan M., van Eijsden Pieter, Leijten Frans S.S., Braun Kees P.J. 29 Oct 2021, In: Clinical Neurophysiology. 133 , p. 126-134 9 p.

All research output

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