drs. T.U. (Marco) Goris

drs. T.U. (Marco) Goris

Associate Professor - medical
drs. T.U. (Marco) Goris
  • Psychiatry

Research Programs




Genetic, epigenetic and epidemiological studies of Gene- Environment interplay

The main theme of my research is how our genetic background shapes the influence of the environmental risk for bipolar disorder and schizophrenia. 

 The idea that psychiatric disorders develop as a result of the interaction between genes and environment is generally supported. However methodological challenges of such studies have limited large scale genome wide efforts. Therefore studies that focus on the interaction between environmental risk and genetic background remain timely and necessary.

 However such genetic studies do not take into account  a more subtle but highly relevant molecular mechanisms of interactions between environment and genes that recently is identified as a key mechanism of adaptation. These mechanisms, referred to as epigenetics, are extensive and complex and to date not fully understood. Central to our understanding is that epigenetic mechanisms influences transcription of DNA by modifying access to the DNA sequences. What makes this line of research extra interesting is the potential for pharmaceutical manipulation.

To focus these studies we have chosen cannabis and trauma as a main environmental exposure. 

Specialties: Psychiatry, epigenetics, genetics, bio-informatics


Fellowship and Awards

1:  NARSAD Young Investigator Award 2010
2: Semel Institute of Neuroscience, 2009 Phenomics Travel Award

Research Output (235)

Powerful eQTL mapping through low-coverage RNA sequencing

Schwarz Tommer, Boltz Toni, Hou Kangcheng, Bot Merel, Duan Chenda, Loohuis Loes Olde, Boks Marco P, Kahn René S, Ophoff Roel A, Pasaniuc Bogdan 14 Jul 2022, In: HGG advances. 3

Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago:FOCUS ON cortisol, thyroid hormones, testosterone and GABA

Feklicheva Inna, Boks Marco P., de Kloet E. Ron, Chipeeva Nadezda, Maslennikova Ekaterina, Pashkov Anton, Korobova Svetlana, Komelkova Mariia, Kuznetsova Yulia, Platkovski Pavel, Mamonova Marina, Sidorenko Olga, Vasilenko Tatyana, Tseilikman Olga, Tseilikman Vadim Apr 2022, In: Journal of Psychiatric Research. 148 , p. 258-263 6 p.

Untargeted metabolic analysis in dried blood spots reveals metabolic signature in 22q11.2 deletion syndrome

Korteling Dorinde, Boks Marco P, Fiksinski Ania M, van Hoek Ilja N, Vorstman Jacob A S, Verhoeven-Duif Nanda M, Jans Judith J M, Zinkstok Janneke R 9 Mar 2022, In: Translational Psychiatry. 12 , p. 1-7

Oxytocin system gene methylation is associated with empathic responses towards children

Spencer Hannah, Parianen Lesemann Franca H., Kraaijenvanger Eline J., Overbeek Geertjan, Montoya Estrella R., Branje Susan, Boks Marco P.M., Bos Peter A. Mar 2022, In: Psychoneuroendocrinology. 137 , p. 1-10

Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum

Schutte Maya J L, Voppel Alban, Collin Guusje, Abramovic Lucija, Boks Marco P M, Cahn Wiepke, van Haren Neeltje E M, Hugdahl Kenneth, Koops Sanne, Mandl René C W, Sommer Iris E C 18 Feb 2022, In: Schizophrenia bulletin. 48 , p. 684-694 11 p.

Bipolar episodes after reproductive events in women with bipolar I disorder, A study of 919 pregnancies

Gilden Janneke, Poels Eline M.P., Lambrichts Simon, Vreeker Annabel, Boks Marco P.M., Ophoff Roel A., Kahn René S., Kamperman Astrid M., Bergink Veerle 1 Dec 2021, In: Journal of Affective Disorders. 295 , p. 72-79 8 p.

Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness

Luykx Jurjen J, Loef Dore, Lin Bochao, van Diermen Linda, Nuninga Jasper O, van Exel Eric, Oudega Mardien L, Rhebergen Didi, Schouws Sigfried N T M, van Eijndhoven Philip, Verwijk Esmée, Schrijvers Didier, Birkenhager Tom K, Ryan Karen M, Arts Baer, van Bronswijk Suzanne C, Kenis Gunter, Schurgers Geert, Baune Bernhard T, Arns Martijn, van Dellen Edwin E, Somers Metten, Sommer Iris E C, Boks Marco P, Gülöksüz Sinan, McLoughlin Declan M, Dols Annemiek, Rutten Bart P F 24 Oct 2021, In: Biological Psychiatry. 91 , p. 531-539 9 p.


Zinkstok Janneke, Korteling Dorinde, Fiksinski Ania, Jans Judith, Verhoeven Nanda, Boks Marco Oct 2021, In: European Neuropsychopharmacology. 51 , p. E130-E130

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Mullins Niamh, Kang JooEun, Campos Adrian I, Coleman Jonathan R I, Edwards Alexis C, Galfalvy Hanga, Levey Daniel F, Lori Adriana, Shabalin Andrey, Starnawska Anna, Su Mei-Hsin, Watson Hunna J, Adams Mark, Awasthi Swapnil, Gandal Michael, Hafferty Jonathan D, Hishimoto Akitoyo, Kim Minsoo, Okazaki Satoshi, Otsuka Ikuo, Ripke Stephan, Ware Erin B, Bergen Andrew W, Berrettini Wade H, Bohus Martin, Brandt Harry, Chang Xiao, Chen Wei J, Chen Hsi-Chung, Crawford Steven, Crow Scott, DiBlasi Emily, Duriez Philibert, Fernández-Aranda Fernando, Fichter Manfred M, Gallinger Steven, Glatt Stephen J, Gorwood Philip, Guo Yiran, Hakonarson Hakon, Halmi Katherine A, Hwu Hai-Gwo, Jain Sonia, Jamain Stéphane, Jiménez-Murcia Susana, Johnson Craig, Boks Marco P, Cahn Wiepke, Kahn René S, Ophoff Roel A, 9 Sep 2021, In: Biological Psychiatry. 91 , p. 313-327 15 p.

Shape and volume changes of the superior lateral ventricle after electroconvulsive therapy measured with ultra-high field MRI

Nuninga Jasper, Mandl René C W, Siero Jeroen, Nieuwdorp Wendy, Heringa Sophie M, Boks Marco P, Somers Metten, Sommer Iris E C 3 Sep 2021, In: Psychiatry Research - Neuroimaging. 317 , p. 1-7

All research output

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