drs. T.U. (Marco) Goris
drs. T.U. (Marco) Goris
- Psychiatry
Research Programs
Biography
Biography
Genetic, epigenetic and epidemiological studies of Gene- Environment interplay
The main theme of my research is how our genetic background shapes the influence of the environmental risk for bipolar disorder and schizophrenia.
The idea that psychiatric disorders develop as a result of the interaction between genes and environment is generally supported. However methodological challenges of such studies have limited large scale genome wide efforts. Therefore studies that focus on the interaction between environmental risk and genetic background remain timely and necessary.
However such genetic studies do not take into account a more subtle but highly relevant molecular mechanisms of interactions between environment and genes that recently is identified as a key mechanism of adaptation. These mechanisms, referred to as epigenetics, are extensive and complex and to date not fully understood. Central to our understanding is that epigenetic mechanisms influences transcription of DNA by modifying access to the DNA sequences. What makes this line of research extra interesting is the potential for pharmaceutical manipulation.
To focus these studies we have chosen cannabis and trauma as a main environmental exposure.
Specialties: Psychiatry, epigenetics, genetics, bio-informatics
Fellowship and Awards
1: NARSAD Young Investigator Award 2010
2: Semel Institute of Neuroscience, 2009 Phenomics Travel Award
Research Output (235)
Schwarz Tommer, Boltz Toni, Hou Kangcheng, Bot Merel, Duan Chenda, Loohuis Loes Olde, Boks Marco P, Kahn René S, Ophoff Roel A, Pasaniuc Bogdan 14 Jul 2022, In: HGG advances. 3
Feklicheva Inna, Boks Marco P., de Kloet E. Ron, Chipeeva Nadezda, Maslennikova Ekaterina, Pashkov Anton, Korobova Svetlana, Komelkova Mariia, Kuznetsova Yulia, Platkovski Pavel, Mamonova Marina, Sidorenko Olga, Vasilenko Tatyana, Tseilikman Olga, Tseilikman Vadim Apr 2022, In: Journal of Psychiatric Research. 148 , p. 258-263 6 p.
Korteling Dorinde, Boks Marco P, Fiksinski Ania M, van Hoek Ilja N, Vorstman Jacob A S, Verhoeven-Duif Nanda M, Jans Judith J M, Zinkstok Janneke R 9 Mar 2022, In: Translational Psychiatry. 12 , p. 1-7
Spencer Hannah, Parianen Lesemann Franca H., Kraaijenvanger Eline J., Overbeek Geertjan, Montoya Estrella R., Branje Susan, Boks Marco P.M., Bos Peter A. Mar 2022, In: Psychoneuroendocrinology. 137 , p. 1-10
Schutte Maya J L, Voppel Alban, Collin Guusje, Abramovic Lucija, Boks Marco P M, Cahn Wiepke, van Haren Neeltje E M, Hugdahl Kenneth, Koops Sanne, Mandl René C W, Sommer Iris E C 18 Feb 2022, In: Schizophrenia bulletin. 48 , p. 684-694 11 p.
Gilden Janneke, Poels Eline M.P., Lambrichts Simon, Vreeker Annabel, Boks Marco P.M., Ophoff Roel A., Kahn René S., Kamperman Astrid M., Bergink Veerle 1 Dec 2021, In: Journal of Affective Disorders. 295 , p. 72-79 8 p.
Luykx Jurjen J, Loef Dore, Lin Bochao, van Diermen Linda, Nuninga Jasper O, van Exel Eric, Oudega Mardien L, Rhebergen Didi, Schouws Sigfried N T M, van Eijndhoven Philip, Verwijk Esmée, Schrijvers Didier, Birkenhager Tom K, Ryan Karen M, Arts Baer, van Bronswijk Suzanne C, Kenis Gunter, Schurgers Geert, Baune Bernhard T, Arns Martijn, van Dellen Edwin E, Somers Metten, Sommer Iris E C, Boks Marco P, Gülöksüz Sinan, McLoughlin Declan M, Dols Annemiek, Rutten Bart P F 24 Oct 2021, In: Biological Psychiatry. 91 , p. 531-539 9 p.
Zinkstok Janneke, Korteling Dorinde, Fiksinski Ania, Jans Judith, Verhoeven Nanda, Boks Marco Oct 2021, In: European Neuropsychopharmacology. 51 , p. E130-E130
Mullins Niamh, Kang JooEun, Campos Adrian I, Coleman Jonathan R I, Edwards Alexis C, Galfalvy Hanga, Levey Daniel F, Lori Adriana, Shabalin Andrey, Starnawska Anna, Su Mei-Hsin, Watson Hunna J, Adams Mark, Awasthi Swapnil, Gandal Michael, Hafferty Jonathan D, Hishimoto Akitoyo, Kim Minsoo, Okazaki Satoshi, Otsuka Ikuo, Ripke Stephan, Ware Erin B, Bergen Andrew W, Berrettini Wade H, Bohus Martin, Brandt Harry, Chang Xiao, Chen Wei J, Chen Hsi-Chung, Crawford Steven, Crow Scott, DiBlasi Emily, Duriez Philibert, Fernández-Aranda Fernando, Fichter Manfred M, Gallinger Steven, Glatt Stephen J, Gorwood Philip, Guo Yiran, Hakonarson Hakon, Halmi Katherine A, Hwu Hai-Gwo, Jain Sonia, Jamain Stéphane, Jiménez-Murcia Susana, Johnson Craig, Boks Marco P, Cahn Wiepke, Kahn René S, Ophoff Roel A, 9 Sep 2021, In: Biological Psychiatry. 91 , p. 313-327 15 p.
Nuninga Jasper, Mandl René C W, Siero Jeroen, Nieuwdorp Wendy, Heringa Sophie M, Boks Marco P, Somers Metten, Sommer Iris E C 3 Sep 2021, In: Psychiatry Research - Neuroimaging. 317 , p. 1-7