prof. dr. L.M. (Stefan) Gastel

prof. dr. L.M. (Stefan) Gastel

Associate Professor - medical
  • Department of Pathology

Research Programs

Strategic Program Cancer



Dr Stefan Willems was trained in medicin (2003 cum laude Catholic University Leuven) with a PhD in molecular pathology (2010, Leiden University) and specialized in pathology (2011, LUMC). After postdoc positions at Harvard Medical School (Gygilab) and NKI  (Bernardslab) he has been working as a pathologist with special interest in molecular pathology and diagnostics. He is co-director of the molecular pathology lab in the University Medical Center Utrecht. He is associate professor in pathology and head of the molecular head and neck cancer line within the UMC Utrecht (1 postdoc, 8 PhDs). He is also affiliated with the department of pathology of the NKI-AvL and performs here translational head and neck research. He is board member of the PALGA Foundation.

Research Output (171)

Correlation and colocalization of HIF-1α and pimonidazole staining for hypoxia in laryngeal squamous cell carcinomas:A digital, single-cell-based analysis

Swartz Justin E, Smits Hilde J G, Philippens Marielle E P, de Bree Remco, H A M Kaanders Johannes, Willems Stefan M 18 Apr 2022, In: Oral Oncology. 128 , p. 1-8

First experiences with 177Lu-PSMA-617 therapy for recurrent or metastatic salivary gland cancer

Klein Nulent Thomas J.W., van Es Robert J.J., Willems Stefan M., Braat Arthur J.A.T., Devriese Lot A., de Bree Remco, de Keizer Bart 14 Dec 2021, In: EJNMMI Research. 11 , p. 1-6

Accurate detection of circulating tumor DNA using nanopore consensus sequencing

Marcozzi Alessio, Jager Myrthe, Elferink Martin, Straver Roy, van Ginkel Joost H, Peltenburg Boris, Chen Li-Ting, Renkens Ivo, van Kuik Joyce, Terhaard Chris, de Bree Remco, Devriese Lot A, Willems Stefan M, Kloosterman Wigard P, de Ridder Jeroen 9 Dec 2021, In: npj Genomic Medicine. 6 , p. 1-11

De-escalation studies in HPV-positive oropharyngeal cancer:How should we proceed?

Golusinski Pawel, Corry June, Poorten Vincent Vander, Simo Ricard, Sjögren Elisabeth, Mäkitie Antti, Kowalski Luis Paulo, Langendijk Johannes, Braakhuis Boudewijn J M, Takes Robert P, Coca-Pelaz Andrés, Rodrigo Juan P, Willems Stefan M, Forastiere Arlene A, De Bree Remco, Saba Nabil F, Teng Yong, Sanabria Alvaro, Di Maio Pasquale, Szewczyk Mateusz, Ferlito Alfio 17 Nov 2021, In: Oral Oncology. 123 , p. 1-8

Considerable interlaboratory variation in PD-L1 positivity in a nationwide cohort of non-small cell lung cancer patients

Koomen Bregje M., Voorham Quirinus J.M., Epskamp-Kuijpers Chantal C.H.J., van Dooijeweert Carmen, van Lindert Anne S.R., Deckers Ivette A.G., Willems Stefan M. Sep 2021, In: Lung Cancer. 159 , p. 117-126 10 p.

Cancer immunotherapy by nc410, a lair-2 fc protein blocking human lair-collagen interaction

Ramos M. Ines Pascoal, Tian Linjie, de Ruiter Emma J., Song Chang, Paucarmayta Ana, Singh Akashdip, Elshof Eline, Vijver Saskia V., Shaik Jahangheer, Bosiacki Jason, Cusumano Zachary, Jensen Christina, Willumsen Nicholas, Karsdal Morten A., Liu Linda, Langermann Sol, Willems Stefan, Flies Dallas, Meyaard Linde 14 Jun 2021, In: eLife. 10 , p. 1-29

False-negative programmed death-ligand 1 immunostaining in ethanol-fixed endobronchial ultrasound-guided transbronchial needle aspiration specimens of non-small-cell lung cancer patients

Koomen Bregje M, Vreuls Willem, de Boer Mirthe, de Ruiter Emma J, Hoelters Juergen, Vink Aryan, Willems Stefan M 8 Jun 2021, In: Histopathology. 79 , p. 480-490 11 p.

Feasibility study of ultrasound-guided resection of tongue cancer with immediate specimen examination to improve margin control – Comparison with conventional treatment

de Koning Klijs J., Koppes Sjors A., de Bree Remco, Dankbaar Jan Willem, Willems Stefan M., van Es Robert J.J., Noorlag Rob May 2021, In: Oral Oncology. 116 , p. 1-7 7 p.

Contralateral Regional Recurrence in Lateralized or Paramedian Early-Stage Oral Cancer Undergoing Sentinel Lymph Node Biopsy—Comparison to a Historic Elective Neck Dissection Cohort

Mahieu Rutger, den Toom Inne J., Boeve Koos, Lobeek Daphne, Bloemena Elisabeth, Donswijk Maarten L., de Keizer Bart, Klop W. Martin C., Leemans C. René, Willems Stefan M., Takes Robert P., Witjes Max J.H., de Bree Remco 23 Apr 2021, In: Frontiers in oncology. 11 10 p.

Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma:A Systematic Review

de Kort W. W.B., Spelier S., Devriese L. A., van Es R. J.J., Willems S. M. Mar 2021, In: Molecular Diagnosis and Therapy. 25 , p. 123-136 14 p.

All research output

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