dr. ir. L.M. Fortes
dr. ir. L.M. Fortes
- Lab Translational Oncology
Research Programs
Biography
Biography
Onno Kranenburg received his PhD in 1995 from Leiden University (Prof Lex van der Eb). He then studied RAS and RHO small GTPase signaling in cancer in the Netherlands Cancer Institute (Prof Wouter Moolenaar). In 2000 he became senior Post-Doc in the Dept of Medical Oncology in the UMC Utrecht (Prof Emile Voest) where he started his translational studies on the mechanism of action of anti-angiogenic drugs. In 2003 he became Assistant Professor and PI at the Dept. of Surgery (Prof Inne Borel Rinkes) and started to work on the mechanisms of colon cancer metastasis, initially focusing on the role of the K-RAS oncogene. In 2006 he became Associate Professor, head of the Surgery Lab and staff member at the Dept. of Surgery. In 2012 he became coordinator of the PhD research school Clinical and Translational Oncology. In 2015 he was appointed Professor of Surgical and Translational Tumor Biology at the Cancer Center UMC Utrecht where he continues to design and test novel strategies for the prevention and treatment of colon cancer metastasis.
Side Activities
2013-present: Coordinator of the PhD program Clinical and Translational Oncology
2005-present Head Laboratory Translational Oncology
2018-present: chair working group translational research Dutch Colorectal Cancer Group (DCCG)
2018-present: Chair U-PORT
Fellowship and Awards
1. KWF2015-8088. Targeting mesenchymal-tyope colon cancer by aggravating oxidative damage. €573.500.
2. Scope: Modulation of chemotherapy efficacy and toxicity by nutrition in metastatic colorectal cancer. €586.000.
3. ZonMw 2014: PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymal-type colon cancer: A window trial. €108.000
4. Gieskes-Strijbis Fonds 2014: The relationship between primary colorectal tumors and their liver metastases: Biological subgroups and therapy response. €290.000
5. Vrienden UMC Utrecht 2013. Title: Targeting colon tumors at their root: Elimination of Cancer Stem Cells. €217.000
6. KWF UU2011-5226 Title: LIMK1 control of CD95 function in colorectal cancer. €553.300
7. KWF UU2011-5135. Suppression of LIMK1 by oncogenic KRAS and RAF1: A critical survival pathway in colorectal cancer? €560.000
8. KWF UU2009-4417. The contribution of CD95 signalling to recurrence of colorectal liver metastases following radiofrequency ablation. €592.100
Research Output (117)
Laoukili Jamila, van Schelven Susanne, Küçükköse Emre, Verheem André, Goey Kaitlyn, Koopman Miriam, Borel Rinkes Inne, Kranenburg Onno 29 Nov 2022, In: Cell Reports. 41
Marvin Dieuwke L, You Li, Bornes Laura, van Dinther Maarten, Peters Niek, Dang Hao, Hakuno Sarah K, Hornsveld Marten, Kranenburg Onno, van Rheenen Jacco, Rohling Jos H T, Chien Miao-Ping, Ten Dijke Peter, Ritsma Laila 19 May 2022, In: Cancers. 14
Bolhuis Karen, Wensink G. Emerens, Elferink Marloes A.G., Bond Marinde J.G., Dijksterhuis Willemieke P.M., Fijneman Remond J.A., Kranenburg Onno W., Borel Rinkes Inne H.M., Koopman Miriam, Swijnenburg Rutger Jan, Vink Geraldine R., Hagendoorn Jeroen, Punt Cornelis J.A., Elias Sjoerd G., Roodhart Jeanine M.L. 2 May 2022, In: Cancers. 14 , p. 1-17
Poghosyan Susanna, Frenkel Nicola, Lentzas Aristeidis, Laoukili Jamila, Rinkes Inne Borel, Kranenburg Onno, Hagendoorn Jeroen 1 Feb 2022, In: Cancers. 14 , p. 1-18
Küçükköse Emre, Wensink G. Emerens, Roelse Celine M., van Schelven Susanne J., Raats Daniëlle A.E., Boj Sylvia F., Koopman Miriam, Laoukili Jamila, Roodhart Jeanine M.L., Kranenburg Onno 1 Nov 2021, In: Cancers. 13 , p. 1-12
Rovers Koen P., Bakkers Checca, Nienhuijs Simon W., Burger Jacobus W.A., Creemers Geert Jan M., Thijs Anna M.J., Brandt-Kerkhof Alexandra R.M., Madsen Eva V.E., Van Meerten Esther, Tuynman Jurriaan B., Kusters Miranda, Versteeg Kathelijn S., Aalbers Arend G.J., Kok Niels F.M., Buffart Tineke E., Wiezer Marinus J., Boerma Djamila, Los Maartje, De Reuver Philip R., Bremers Andreas J.A., Verheul Henk M.W., Kruijff Schelto, De Groot Derk Jan A., Witkamp Arjen J., Van Grevenstein Wilhelmina M.U., Koopman Miriam, Nederend Joost, Lahaye Max J., Kranenburg Onno, Fijneman Remond J.A., Van 'T Erve Iris, Snaebjornsson Petur, Hemmer Patrick H.J., Dijkgraaf Marcel G.W., Punt Cornelis J.A., Tanis Pieter J., De Hingh Ignace H.J.T. Aug 2021, In: JAMA Surgery. 156 , p. 710-720 11 p.
Frenkel Nicola, Poghosyan Susanna, Alarcón Carmen Rubio, García Silvia Bonilla, Queiroz Karla, Van Den Bent Lotte, Laoukili Jamila, Rinkes Inne Borel, Vulto Paul, Kranenburg Onno, Hagendoorn Jeroen 12 Jul 2021, In: ACS Biomaterials Science and Engineering. 7 , p. 3030-3042 13 p.
Sacchetti Andrea, Teeuwssen Miriam, Verhagen Mathijs, Joosten Rosalie, Xu Tong, Stabile Roberto, van der Steen Berdine, Watson Martin M., Gusinac Alem, Kim Won Kyu, Ubink Inge, Van de Werken Harmen J.G., Fumagalli Arianna, Paauwe Madelon, Van Rheenen Jacco, Sansom Owen J., Kranenburg Onno, Fodde Riccardo 26 May 2021, In: eLife. 10 , p. 1-28
Wenmaekers Stijn, Viergever Bastiaan J., Kumar Gunjan, Kranenburg Onno, Black Peter C., Daugaard Mads, Meijer Richard P. 20 May 2021, In: Cells. 10 19 p.
Wijler Liza A, Raats Danielle A E, Elias Sjoerd G, Dijk Francina J, Quirindongo Hanil, May Anne M, Furber Matthew J W, Dorresteijn Bram, van Dijk Miriam, Kranenburg Onno 6 May 2021, In: Journal of Cachexia, Sarcopenia and Muscle. 12 , p. 796-810 15 p.