ds. F.G.G. (Linda) de Schreuders

ds. F.G.G. (Linda) de Schreuders

Professor Emeritus
ds. F.G.G. (Linda) de Schreuders
  • Birth Center Neonatology - Medical



Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.


Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
4: Harwood Nash memorial lecture, Toronto, 2012
5: McCance Lecture (British Neonatal Society), 2004
6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (653)

A uniform description of perioperative brain MRI findings in infants with severe congenital heart disease:Results of a European collaboration

Stegeman R., Feldmann M., Claessens N. H.P., Jansen N. J.G., Breur J. M.P.J., de Vries L. S., Logeswaran T., Reich B., Knirsch W., Kottke R., Hagmann C., Latal B., Simpson J., Pushparajah K., Bonthrone A. F., Kelly C. J., Arulkumaran S., Rutherford M. A., Counsell S. J., Benders M. J.N.L., 1 Nov 2021, In: American Journal of Neuroradiology. 42 , p. 2034-2039 6 p.

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse, van Huffelen Alexander, van Klink Nicole, Benders Manon, de Vries Linda, Leijten Frans, Jansen Floor E., Braun Kees, Zijlmans Maeike Nov 2021, In: Epilepsia. 62 , p. 114-115

Neonatal stroke in premature neonates

Steggerda S. J., de Vries L. S. Nov 2021, In: Seminars in perinatology. 45 , p. 1-9

Neuroimaging in the term newborn with neonatal encephalopathy

Wisnowski Jessica L, Wintermark Pia, Bonifacio Sonia L, Smyser Christopher D, Barkovich A James, Edwards A David, de Vries Linda S, Inder Terrie E, Chau Vann, 29 Oct 2021, In: Seminars in Fetal & Neonatal Medicine. 26 , p. 1-13

Motor Developmental Delay After Cardiac Surgery in Children With a Critical Congenital Heart Defect:A Systematic Literature Review and Meta-analysis

Sprong Maaike C A, Broeders Willem, van der Net Janjaap, Breur Johannes M P J, de Vries Linda S, Slieker Martijn G, van Brussel Marco 1 Oct 2021, In: Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association. 33 , p. 186-197 12 p.

Preliminary results of the PASSIoN trial (Perinatal Arterial Stroke treated with Stromal cells IntraNasally)

Baak Lisanne M., Wagenaar Nienke, van der Aa Niek E., Groenendaal Floris, Dudink Jeroen, Tataranno Maria-Luisa, Smit Liesbeth S., Jellema Reint K., de Haan Timo R., ter Horst Henk J., de Boode Willem P., Steggerda Sylke J., de Haar Colin G., de Vries Linda S., van Bel Frank, Nijboer Cora H. A., Benders Manon J. N. L. Oct 2021, In: Pediatric Research. 90 , p. 8-8

Intraparenchymal hemorrhage after serial ventricular reservoir taps in neonates with hydrocephalus and association with neurodevelopmental outcome at 2 years of age

Cizmeci Mehmet N., de Vries Linda S., Tataranno Maria Luisa, Zecic Alexandra, van de Pol Laura A., Alarcon Ana, Groenendaal Floris, Woerdeman Peter A. 17 Sep 2021, In: Journal of Neurosurgery: Pediatrics. 28 , p. 695-702 8 p.

Ultrasound measurements of brain structures differ between moderate-late preterm and full-term infants at term equivalent age

Boswinkel Vivian, Sok Femke I., Krüse-Ruijter Martine F., Nijholt Ingrid M., Jansen Fenna A.R., Haak Monique C., Boomsma Martijn F., de Vries Linda S., Steggerda Sylke J., van Wezel-Meijler Gerda Sep 2021, In: Early Human Development. 160 , p. 1-8

Mild brain lesions do not affect brain volumes in moderate-late preterm infants

Boswinkel Vivian, Verschuur Anouk S, Nijholt Ingrid M, van Osch Jochen A C, Nijboer-Oosterveld Jacqueline, Beare Richard J, Slump Cornelis H, de Vries Linda S, Boomsma Martijn F, van Wezel-Meijler Gerda 17 Aug 2021, In: European Journal of Paediatric Neurology. 34 , p. 91-98 8 p.

Timing of Intraventricular Hemorrhage in Preterm Neonates Reply

Inder Terrie E, de Vries Linda S, Ment Laura R 11 Aug 2021, In: The Journal of Pediatrics. 239 , p. 248-249 2 p.

All research output

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