ing. S. (Lieza) Buurma

ing. S. (Lieza) Buurma

Assistant Professor - medical
  • Neurologen



Lieza Exalto, is a neurologist who has received her medical training in the UMC Utrecht. In 2014 she obtained her PhD degree with the thesis “Diabetes and Dementia, the bitter taste of a sweet disease”. Afterwards she continued her research in the Vascular Cognitive Impairment group of prof. Biessels and introduced sex and gender differences as relevant research topic. Lieza received funding from Alzheimer Nederland for her project “Does sex modulate the phenotype and prognosis of vascular cognitive impairment”.


Lieza is work-package leader “sex differences” in the Dutch Heart-Brain Consortium study. She collaborates with the META-VCI MAP consortium on research projects on sex differences in post-stroke cognitive impairment. In the European multicenter H2020 study RECOGNISED, she is work-package leader of the cognitive testing. In February 2020 she received the prize for best integration of sex and gender considerations in cardiovascular research plans, during the Libin International Trainee Symposium: Research is Better with Sex and Gender! 

Research Output (30)

Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease-related brain injury

De Luca Alberto, Kuijf Hugo, Exalto Lieza, Thiebaut de Schotten Michel, Biessels Geert-Jan, Sep 2022, In: Brain structure & function. 227 , p. 2553-2567 15 p.

Neuropsychiatric Symptoms as Predictor of Poor Clinical Outcome in Patients With Vascular Cognitive Impairment

Sep Yoni C P, Leeuwis Anna E, Exalto Lieza G, Boomsma Jooske M, Prins Niels D, Verwer Jurre H, Scheltens Philip, van der Flier Wiesje M, Biessels Geert Jan, 2 Jan 2022, In: The American Journal of Geriatric Psychiatry. 30 , p. 813-824 12 p.

Females with type 2 diabetes are at higher risk for accelerated cognitive decline than males:CAROLINA-COGNITION study

Verhagen Chloë, Janssen Jolien, Biessels Geert Jan, Johansen Odd Erik, Exalto Lieza G 27 Oct 2021, In: NMCD : Nutrition metabolism and cardiovascular diseases. 32 , p. 355-364 10 p.

Sex and Cardiovascular Function in Relation to Vascular Brain Injury in Patients with Cognitive Complaints

Kuipers Sanne, Biessels Geert Jan, Greving Jacoba P, Amier Raquel P, de Bresser Jeroen, Bron Esther E, van der Flier Wiesje M, van der Geest Rob J, Hooghiemstra Astrid M, van Oostenbrugge Robert J, van Osch Matthias J P, Kappelle L Jaap, Exalto Lieza G, 26 Oct 2021, In: Journal of Alzheimer's Disease. 84 , p. 261-271 11 p.

Call Characteristics of Patients Suspected of Transient Ischemic Attack (TIA) or Stroke During Out-of-Hours Service:A Comparison Between Men and Women

Exalto Lieza G., van Doorn Sander, Erkelens D. Carmen A., Smit Karin, Rutten Frans H., Kappelle L. Jaap, Zwart Dorien L.M. 14 Jun 2021, In: Frontiers in Neurology. 12

Cerebral Perfusion and the Burden of Small Vessel Disease in Patients Referred to a Memory Clinic

Onkenhout Laurien, Appelmans Nadine, Kappelle L Jaap, Koek Dineke, Exalto Lieza, de Bresser Jeroen, Biessels Geert Jan, Nov 2020, In: Cerebrovascular diseases (Basel, Switzerland). 49 , p. 481-486 6 p.

Diabetes-specific dementia risk score (DSDRS) predicts cognitive performance in patients with type 2 diabetes at high cardio-renal risk

Verhagen Chloë, Janssen Jolien, Exalto Lieza G, van den Berg Esther, Johansen Odd Erik, Biessels Geert Jan 16 Jul 2020, In: Journal of Diabetes and its Complications. 34

Author response: Clinical relevance of acute cerebral microinfarct in vascular cognitive impairment:Clinical relevance of acute cerebral microinfarcts in vascular cognitive impairment

Ferro Doeschka A, van den Brink Hilde, Exalto Lieza G, Boomsma Jooske M F, Barkhof Frederik, Prins Niels D, van der Flier Wiesje M, Biessels Geert Jan 18 Feb 2020, In: Neurology. 94 , p. 330-330 1 p.

Prediction of poor clinical outcome in vascular cognitive impairment:TRACE-VCI study

Boomsma Jooske M F, Exalto Lieza G, Barkhof Frederik, Chen Christopher L H, Hilal Saima, Leeuwis Anna E, Prins Niels D, Saridin Francis N, Scheltens Philip, Teunissen Charlotte E, Verwer Jurre H, Weinstein Henry C, van der Flier Wiesje M, Biessels Geert Jan, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12 , p. 1-12

Small vessel disease lesion type and brain atrophy:The role of co-occurring amyloid

Heinen Rutger, Groeneveld Onno N, Barkhof Frederik, de Bresser Jeroen, Exalto Lieza G, Kuijf Hugo J, Prins Niels D, Scheltens Philip, van der Flier Wiesje M, Biessels Geert Jan, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12 , p. 1-11

All research output

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