drs. X.Y.Y. Breugelmans

drs. X.Y.Y. Breugelmans

Associate Professor
drs. X.Y.Y. Breugelmans
  • Center for Translational Immunology (CTI) Research



  1. Biograpy: Obtained his PhD in Hungary at University of Debrecen, where he became fascinated by biophysical techniques that he learned to use to study molecular interactions in living cells. He was further trained in the Babraham Institute In Cambridge (UK) and later at the ErasmusMC in Rotterdam (NL) where he as postdoctoral fellow has studied the molecular needs of genetic engineering of T cells for the immunotherapy of cancer. He continued his career at the UMCU in Utrecht, where he was appointed in 2014 as staff member of Section Applied within the Laboratory of Translational Immunology. He is currently focusing on the developement of novel gamma delta T cell-based immunotherapies and the better understanding of innate T cell and tumour cell interactions.  Reserach interest:  Tumour recognition of innate immune cells, Immune receptors , Genetic engineering

Research Output (22)

The Role of γδ T Cells as a Line of Defense in Viral Infections after Allogeneic Stem Cell Transplantation:Opportunities and Challenges

Janssen Anke, van Diest Eline, Vyborova Anna, Schrier Lenneke, Bruns Anke, Sebestyen Zsolt, Straetemans Trudy, de Witte Moniek, Kuball Jürgen Jan 2022, In: Viruses. 14 , p. 1-15

Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Van Diest Eline, Hernández López Patricia, Meringa Angelo D., Vyborova Anna, Karaiskaki Froso, Heijhuurs Sabine, Gumathi Bormin Jan, Van Dooremalen Sanne, Nicolasen Mara J.T., Gatti Lucrezia C.D.E., Johanna Inez, Straetemans Trudy, Sebestyén Zsolt, Beringer Dennis X., Kuball Jürgen 23 Nov 2021, In: Journal for ImmunoTherapy of Cancer. 9 , p. 1-15

Adding Help to an HLA-A*24:02 Tumor-Reactive gamma delta TCR Increases Tumor Control

Johanna Inez, Hernández-López Patricia, Heijhuurs Sabine, Scheper Wouter, Bongiovanni Laura, de Bruin Alain, Beringer Dennis X., Oostvogels Rimke, Straetemans Trudy, Sebestyen Zsolt, Kuball Jürgen 25 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-12

Characterization and modulation of anti-alpha beta TCR antibodies and their respective binding sites at the beta TCR chain to enrich engineered T cells

Kierkels Guido J J, van Diest Eline, Hernández-López Patricia, Scheper Wouter, de Bruin Anja C M, Frijlink Elselien, Aarts-Riemens Tineke, van Dooremalen Sanne F J, Beringer Dennis X, Oostvogels Rimke, Kramer Lovro, Straetemans Trudy, Uckert Wolfgang, Sebestyén Zsolt, Kuball Jürgen 10 Sep 2021, In: Molecular Therapy - Methods and Clinical Development. 22 , p. 388-400 13 p.

gamma 9 delta 2T cell diversity and the receptor interface with tumor cells

Vyborova Anna, Beringer Dennis X, Fasci Domenico, Karaiskaki Froso, van Diest Eline, Kramer Lovro, de Haas Aram, Sanders Jasper, Janssen Anke, Straetemans Trudy, Olive Daniel, Leusen Jeanette Hw, Boutin Lola, Nedellec Steven, Schwartz Samantha L, Wester Michael J, Lidke Keith A, Scotet Emmanuel, Lidke Diane, Heck Albert Jr, Sebestyen Zsolt, Kuball Jurgen 2 Jun 2020, In: Journal of Clinical Investigation. 130 , p. 4637-4651 15 p.

TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice

Johanna Inez, Hernández-López Patricia, Heijhuurs Sabine, Bongiovanni Laura, de Bruin Alain, Beringer Dennis, van Dooremalen Sanne, Shultz Leonard D, Ishikawa Fumihiko, Sebestyen Zsolt, Straetemans Trudy, Kuball Jürgen 5 Feb 2020, In: Journal of Leukocyte Biology. 107 , p. 1069-1079 11 p.

gamma delta T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity

Janssen Anke, Villacorta Hidalgo José, Beringer Dennis X, van Dooremalen Sanne F.J., Fernando Febilla, van Diest Eline, Terrizzi Antonela R, Bronsert Peter, Kock Sylvia, Schmitt-Graeff Annette, Werner Martin, Heise Kerstin, Follo Marie, Straetemans Trudy, Sebestyen Zsolt, Chudakov Dmitriy M, Kasatskaya Sofya A, Frenkel Felix E, Ravens Sarina, Spierings Eric, Prinz Immo, Küppers Ralf, Malkovsky Miroslav, Fisch Paul, Kuball Jurgen 4 Feb 2020, In: Cancer Immunology Research. 8 , p. 530-543 14 p.

TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product

Straetemans Trudy, Janssen Anke, Jansen Koen, Doorn Ruud, Aarts Tineke, van Muyden Anna D D, Simonis Marieke, Bergboer Judith, de Witte Moniek, Sebestyen Zsolt, Kuball Jurgen 14 Dec 2019, In: Molecular Therapy. 28 , p. 561-571 11 p.

Identification of a tumor-specific allo-HLA-restricted γδTCR

Kierkels G J J, Scheper W, Meringa A D, Johanna I, Beringer D X, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen J H W, San José E, Fuchs K, Griffioen M, Falkenburg J H, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck A J R, Shultz L D, Ishikawa F, Nishimura M I, Sebestyén Z, Kuball J 8 Oct 2019, In: Blood Advances. 3 , p. 2870-2882 13 p.

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

Sebestyen Zsolt, Prinz Immo, Déchanet-Merville Julie, Silva-Santos Bruno, Kuball Jurgen 6 Sep 2019, In: Nature Reviews. Drug Discovery. 19 , p. 169-184 16 p.

All research output

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