drs. P.Q. (Hilleke) Blezer

drs. P.Q. (Hilleke) Blezer

Full Professor
drs. P.Q. (Hilleke) Blezer
  • Psychiatry



Hilleke Hulshoff Pol completed her MS degree in psychophysiology with Rien Verbaten in Utrecht (1987), her internship in neuropsychology and neuroimaging with Nelson Butters at the University of California in San Diego (1988), and subsequently her PhD degree in Utrecht (September 25, 1995) with Jan van Ree (neuropharmacology), Max Viergever (imaging), and Cees Tulleken (neurosurgery). Topic of her thesis was memory processes in the frontal cortex of the human brain. Between 1996 and 2006 she set up and headed the brain imaging research lab at the Department of Psychiatry in Utrecht. Since 2007 she is full professor of neuroscience in particular of psychiatric disorders at the Brain Center Rudolf Magnus.

Her research focuses on structural and functional brain plasticity throughout life in health and in psychiatric disease, and the influences of genes and environment on brain plasticity. For this purpose she studies individuals and their (twin) family members, using magnetic resonance imaging at (ultra) high field. She has received a VIDI award from the Netherlands Scientific Organization NWO, and a High Potential award from the Utrecht University. Her work was published in >220 publications, her current h-index is 64, and has been cited >15.800 times.

Research line

Brain plasticity

Most recent key publications

1:Teeuw J., Brouwer R.M., Guimarães, J.P.O.F.T., Brandner, P., Koenis M., Swagerman S., Verwoert, M., Boomsma D.I., Hulshoff Pol H.E. (2019) Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls. Neuroimage. doi: 10.1016/j.neuroimage.2019.116073

2:Brouwer RM Panizzon MS Glahn DC, Hibar DP, Hua X, Jahanshad N, Abramovic L, de Zubicaray GI Franz CE, Hansell NK, Hickie IB, Koenis MMG, Martin NG, Mather KA, McMahon KL, Schnack HG, Strike LT, Swagerman SC, Thalamuthu A, Wen W, Gilmore JH, Gogtay N, Kahn RS, Sachdev PS, Wright MJ, Boomsma DI, Kremen WS, Thompson PM, Hulshoff Pol HE. (2017). Genetic influences on longitudinal changes in global and subcortical brain volumes: results of the ENIGMA Plasticity Working Group. Hum Brain Mapp. 38(9):4444-4458

3:Bohlken MM, Brouwer RM, Mandl RC, Van den Heuvel MP, Hedman AM, De Hert M, Cahn W, Kahn RS, Hulshoff Pol HE. (2016). Structural Brain Connectivity as a Genetic Marker for Schizophrenia. JAMA Psychiatry. 73(1):11-9.

4:Svatkova A, Mandl RC, Scheewe TW, Cahn W, Kahn RS, Hulshoff Pol HE. (2015). Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls. Schizophr Bull.41(4):869-78.

5:Schnack HG, van Haren NE, Brouwer RM, Evans A, Durston S, Boomsma DI, Kahn RS, Hulshoff Pol HE. (2015). Changes in thickness and surface area of the human cortex and their relationship with intelligence. Cereb Cortex. 25(6):1608-17.

6:Marsman A, Mandl RC, Klomp DW, Bohlken MM, Boer VO, Andreychenko A, Cahn W, Kahn RS, Luijten PR, Hulshoff Pol HE. (2014). GABA and glutamate in schizophrenia: a 7 T ¹H-MRS study. Neuroimage Clin. 15;6:398-407.

Side Activities


Fellowship and Awards

Alzheimer's Association Zenith Award Program (subaward PI) 2020

NWA Ideas Generator (one of the PIs) 2020

NIH ENIGMA World Aging Center (subward PI) 2018

NWA NeuroLabNL (subward PI) 2018

Dutch Brain Foundation (subaward PI) 2018

NWO National Roadmap BBMRI-NL2.0 (one of the PIs) 2014

NWO Gravitation Grant CID (one of the PIs), 2012

NWO  NIHC Brain and Cognition, programmes of excellence (PI), 2010

High Potential Program Utrecht University (one of the two PIs), 2007

Marie Curie research training network (PI for Utrecht), 2007

NWO ZON-MW VIDI program (PI), 2004

Research Output (300)

Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children

Hagenbeek Fiona A, van Dongen Jenny, Pool René, Harms Amy C, Roetman Peter J, Fanos Vassilios, van Keulen Britt J, Walker Brian R, Karu Naama, Hulshoff Pol Hilleke E, Rotteveel Joost, Finken Martijn J J, Vermeiren Robert R J M, Kluft Cornelis, Bartels Meike, Hankemeier Thomas, Boomsma Dorret I 24 May 2022, In: Metabolites. 12

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Brouwer Rachel M, Klein Marieke, Grasby Katrina L, Schnack Hugo G, Jahanshad Neda, Teeuw Jalmar, Thomopoulos Sophia I, Sprooten Emma, Franz Carol E, Gogtay Nitin, Kremen William S, Panizzon Matthew S, Olde Loohuis Loes M, Whelan Christopher D, Aghajani Moji, Alloza Clara, Alnæs Dag, Artiges Eric, Ayesa-Arriola Rosa, Barker Gareth J, Bastin Mark E, Blok Elisabet, Bøen Erlend, Breukelaar Isabella A, Bright Joanna K, Buimer Elizabeth E L, Bülow Robin, Cannon Dara M, Ciufolini Simone, Crossley Nicolas A, Damatac Christienne G, Dazzan Paola, de Mol Casper L, de Zwarte Sonja M C, Desrivières Sylvane, Díaz-Caneja Covadonga M, Janssen Joost, Koevoets Martijn G J C, Mandl René C W, Setiaman Nikita, van Haren Neeltje E M, Westeneng Henk-Jan, van Eijk Kristel R, Cahn Wiepke, Hillegers Manon, Kahn Rene S, Ophoff Roel A, van den Berg Leonard H, Veldink Jan H, Hulshoff Pol Hilleke E, Apr 2022, In: Nature Neuroscience. 25 , p. 421-432 12 p.

Longitudinal Allometry of Sulcal Morphology in Health and Schizophrenia

Janssen Joost, Alloza Clara, Díaz-Caneja Covadonga M, Santonja Javier, Pina-Camacho Laura, Gordaliza Pedro M, Fernández-Pena Alberto, Lois Noemi González, Buimer Elizabeth E L, van Haren Neeltje E M, Cahn Wiepke, Vieta Eduard, Castro-Fornieles Josefina, Bernardo Miquel, Arango Celso, Kahn René S, Hulshoff Pol Hilleke E, Schnack Hugo G 22 Mar 2022, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 , p. 3704-3715 12 p.

Multivariate Genetic Structure of Externalizing Behavior and Structural Brain Development in a Longitudinal Adolescent Twin Sample

Teeuw Jalmar, Klein Marieke, Mota Nina Roth, Brouwer Rachel M, van 't Ent Dennis, Al-Hassaan Zyneb, Franke Barbara, Boomsma Dorret I, Hulshoff Pol Hilleke E 15 Mar 2022, In: International journal of molecular sciences. 23

Integrating Cognitive Developmental Neuroscience in Society:Lessons Learned From a Multidisciplinary Research Project on Education and Social Safety of Youth

Vandenbroucke Annelinde R.E., Crone Eveline A., Erp Jan B.F.van, Güroğlu Berna, Hulshoff Pol Hilleke E., de Kogel Catherina H., Krabbendam Lydia, Jansen Lucres M.C., Brouwer Anne Marie 22 Nov 2021, In: Frontiers in Integrative Neuroscience. 15 , p. 1-13 13 p.

Self-regulation in the pre-adolescent brain

Pas P., Hulshoff Pol H. E., Raemaekers M., Vink M. Oct 2021, In: Developmental Cognitive Neuroscience. 51 , p. 1-10 10 p.

Alcohol use and brain morphology in adolescence:a longitudinal study in three different cohorts

El Marroun Hanan, Klapwijk Eduard T, Koevoets Martijn, Brouwer Rachel M, Peters Sabine, van 't Ent Dennis, Boomsma Dorret I, Muetzel Ryan, Crone Eveline A, Hulshoff Pol Hilleke E, Franken Ingmar H A 18 Aug 2021, In: European Journal of Neuroscience. 54 , p. 6012-6026 15 p.

Sex Differences in Lifespan Trajectories and Variability of Human Sulcal and Gyral Morphology

Díaz-Caneja Covadonga M, Alloza Clara, Gordaliza Pedro M, Fernández-Pena Alberto, de Hoyos Lucía, Santonja Javier, Buimer Elizabeth E L, van Haren Neeltje E M, Cahn Wiepke, Arango Celso, Kahn René S, Hulshoff Pol Hilleke E, Schnack Hugo G, Janssen Joost 26 Jun 2021, In: Cerebral Cortex. 31 , p. 5107-5120 14 p.

De‐identification procedures for magnetic resonance images and the impact on structural brain measures at different ages

Buimer Elizabeth, Schnack Hugo, Caspi Yaron, van Haren Neeltje, Milchenko Mikhail, Pas P, ADNI , Hulshoff Pol Hilleke, Brouwer Rachel 11 May 2021, In: Human Brain Mapping. 42 , p. 3643-3655

Reliability modelling of resting-state functional connectivity

Teeuw Jalmar, Hulshoff Pol Hilleke E., Boomsma Dorret I., Brouwer Rachel M. 1 May 2021, In: NeuroImage. 231 12 p.

All research output

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