mr. G.H. (Eric) Besteman

mr. G.H. (Eric) Besteman

Associate Professor
mr. G.H. (Eric) Besteman
  • Central Diagnostic Laboratory



Dr. Spierings received his PhD degree as immunologist at the Leiden University Medical Center, The Netherlands and was subsequently recognized as SMBWO Immunologist by the Dutch Society for Immunology. His postdoctoral training was performed on minor H antigens in organ- and stem-cell transplantation in the laboratory of Prof. Dr. Els Goulmy, Leiden, The Netherlands. In 2008, he was appointed as lab director of the HLA laboratory of the University Medical Centre Utrecht, The Netherlands. In that position, he combines diagnostic histocompatibility testing with research. His current scientific interest focusses on the role of indirect recognition of mismatched HLA in transplantation and on post-transplant immunomonitoring via Next Generation Sequencing of T- and B-cell receptors and immunoglobulins.

Side Activities

  • Associate editor: Frontiers in Immunology ( Section Alloimmunity and Transplantation)
  • Editorial Board: HLA
  • Editorial board: Cellular Immunology
  • Co-chair for the 18th International HLA & Immunogenetics Workshop (
  • Co-chair for the 35th Conference of the European Federation for Immunogenetics
  • Chair of the Bio-informatics Committee of the European Federation for Immunogenetics
  • Head of the Matchis Expertise Center, Leiden, The Netherlands

Fellowship and Awards

  • 1997: KNAW van Walree Grant
  • 2002: Best Abstract Award – 13th International Histocompatibility Workshop Conference 
  • 2004: Special Fellow – Leukemia and Lymphoma Society 
  • 2007: Best Abstract Award – European Federation for Immunogenetics Conference
  • 2009: Best Abstract Award – European Federation for Immunogenetics Conference
  • 2013: Ureka Mega Challenge Award for Innovation – UMC Utrecht
  • 2016: Novartis Award for best scientific publication – Dutch Transplantation Society
  • 2017: Medical Immunology Science Award – Dutch Society for Immunology

Research Output (107)

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Peereboom Emma T M, Matern Benedict M, Tomosugi Toshihide, Niemann Matthias, Drylewicz Julia, Joosten Irma, Allebes Wil A, van der Meer Arnold, Hilbrands Luuk B, Baas Marije C, van Reekum Franka E, Verhaar Marianne C, Kamburova Elena G, Seelen Marc A J, Sanders Jan Stephan, Hepkema Bouke G, Lambeck Annechien J, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christien E, Wieten Lotte, van Duijnhoven Elly M, Gelens Mariëlle A C J, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Azam, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A, van der Weerd Neelke C, Ten Berge Ineke J M, Bemelman Fréderike J, de Vries Aiko P J, de Fijter Johan W, Betjes Michiel G H, Roelen Dave L, Claas Frans H, Otten Henny G, Heidt Sebastiaan, van Zuilen Arjan D, Kobayashi Takaaki, Geneugelijk Kirsten, Spierings Eric 18 Nov 2021, In: Frontiers in Immunology. 12 , p. 1-13

KIR3DS1 directs NK cell-mediated protection against human adenovirus infections

Jung Johannes M, Ching Wilhelm, Baumdick Martin E, Hofmann-Sieber Helga, Bosse Jens B, Koyro Tobias, Möller Kimberly J, Wegner Lucy, Niehrs Annika, Russu Kristina, Ohms Mareike, Zhang Wenli, Ehrhardt Anja, Duisters Kevin, Spierings Eric, Hölzemer Angelique, Körner Christian, Jansen Suze A, Peine Sven, Königs Ingo, Lütgehetmann Marc, Perez Daniel, Reinshagen Konrad, Lindemans Caroline A, Altfeld Marcus, Belderbos Mirjam, Dobner Thomas, Bunders Madeleine J 17 Sep 2021, In: Science Immunology. 6 , p. 1-13 14 p.

Next-Generation HLA Sequence Analysis Uncovers Shared Risk Alleles Between Clinically Distinct Forms of Childhood Uveitis

Wennink Roos A W, de Boer Joke H, Hiddingh Sanne, Haasnoot Anne-Mieke J W, Kalinina Ayuso Viera, de Hoop Talitha, van Setten Jessica, Spierings Eric, Kuiper Jonas J W 1 Jul 2021, In: Investigative ophthalmology & visual science. 62 , p. 1-12

Computational Eurotransplant kidney allocation simulations demonstrate the feasibility and benefit of T-cell epitope matching

Niemann Matthias, Lachmann Nils, Geneugelijk Kirsten, Spierings Eric Jul 2021, In: PLoS Computational Biology. 17 , p. 1-22

Clinical Significance of Shared T Cell Epitope Analysis in Early De Novo Donor-Specific Anti-HLA Antibody Production After Kidney Transplantation and Comparison With Shared B cell Epitope Analysis

Tomosugi Toshihide, Iwasaki Kenta, Sakamoto Shintaro, Niemann Matthias, Spierings Eric, Nahara Isao, Futamura Kenta, Okada Manabu, Hiramitsu Takahisa, Takeda Asami, Goto Norihiko, Narumi Shunji, Watarai Yoshihiko, Kobayashi Takaaki 26 Mar 2021, In: Frontiers in Immunology. 12 16 p.

Standard reference sequences for submission of HLA genotyping for the 18th International HLA and Immunogenetics Workshop

Matern Benedict M, Mack Steven J, Osoegawa Kazutoyo, Maiers Martin, Niemann Matthias, Robinson James, Heidt Sebastiaan, Spierings Eric 2021, In: HLA. 97 , p. 512-519 8 p.


Mijnheer G., Servaas N., Lutter L., Leong J. Y., Spierings E., Chen P., Petrelli A., Vastert S., de Boer R., Albani S., van Loosdregt J., Pandit A., van Wijk F. 2021, In: Clinical and Experimental Rheumatology. 39 , p. 1153-1154

Peptides Derived From Mismatched Paternal Human Leukocyte Antigen Predicted to Be Presented by HLA-DRB1, -DRB3/4/5, -DQ, and -DP Induce Child-Specific Antibodies in Pregnant Women

Niemann Matthias, Matern Benedict M, Spierings Eric, Schaub Stefan, Hönger Gideon 2021, In: Frontiers in Immunology. 12 , p. 1-12

Genetics-first approach improves diagnostics of ESKD patients <50 years old

Snoek Rozemarijn, van Jaarsveld Richard H, Nguyen Tri Q, Peters Edith D J, Elferink Martin G, Ernst Robert F, Rookmaaker Maarten B, Lilien Marc R, Spierings Eric, Goldschmeding Roel, Knoers Nine V A M, van der Zwaag Bert, van Zuilen Arjan D, van Eerde Albertien M 11 Dec 2020, In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 37 , p. 349-357 9 p.

Analysis of T and B Cell Epitopes to Predict the Risk of de novo Donor-Specific Antibody (DSA) Production After Kidney Transplantation:A Two-Center Retrospective Cohort Study

Sakamoto Shintaro, Iwasaki Kenta, Tomosugi Toshihide, Niemann Matthias, Spierings Eric, Miwa Yuko, Horimi Kosei, Takeda Asami, Goto Norihiko, Narumi Shunji, Watarai Yoshihiko, Kobayashi Takaaki 27 Aug 2020, In: Frontiers in Immunology. 11

All research output

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