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Human iPSCs - Advanced Disease Modelling

Human iPSCs - Advanced Disease Modelling

Research Topics uitklapper, klik om te openen

To be added.

Key Publications uitklapper, klik om te openen

Buikema JW, Lee S, Goodyer WR, Maas RG, Chirikian O, Li G, Miao Y, Paige SL, Lee D, Wu H, Paik DT, Rhee S, Tian L, Galdos FX, Puluca N, Beyersdorf B, Hu J, Beck A, Venkamatran S, Swami S, Wijnker P, Schuldt M, Dorsch LM, van Mil A, Red-Horse K, Wu JY, Geisen C, Hesse M, Serpooshan V, Jovinge S, Fleischmann BK, Doevendans PA, van der Velden J, Garcia KC, Wu JC, Sluijter JPG, Wu SM. Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes. Cell Stem Cell. 2020 Jul 2;27(1):50-63.e5. doi: 10.1016/j.stem.2020.06.001. PMID: 32619518; PMCID: PMC7334437.

Buikema JW, Wu SM. Untangling the Biology of Genetic Cardiomyopathies with Pluripotent Stem Cell Disease Models. Curr Cardiol Rep. 2017 Apr;19(4):30. doi: 10.1007/s11886-017-0842-1. PMID: 28315121.

Sharma A*, Zhang Y*, Buikema JW*, Serpooshan V, Chirikian O, Kosaric N, Churko JM, Dzilic E, Shieh A, Burridge PW, Wu JC, Wu SM. Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Sci Rep. 2018 Apr 26;8(1):6618. doi: 10.1038/s41598-018-24954-3. PMID: 29700394; PMCID: PMC5920079.

Buikema JW, Mady AS, Mittal NV, Atmanli A, Caron L, Doevendans PA, Sluijter JP, Domian IJ. Wnt/β-catenin signaling directs the regional expansion of first and second heart field-derived ventricular cardiomyocytes. Development. 2013 Oct;140(20):4165-76. doi: 10.1242/dev.099325. Epub 2013 Sep 11. PMID: 24026118; PMCID: PMC3787756.

Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW. Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes. STAR Protoc. 2021 Feb 9;2(1):100334. doi: 10.1016/j.xpro.2021.100334. PMID: 33615277; PMCID: PMC7881265.

Facilities Involved uitklapper, klik om te openen

iPSC Facility

Live Heart Bank

Contact uitklapper, klik om te openen

Jan Willem Buikema

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