prof. dr. N.M. (Nico M.) Wulffraat

prof. dr. N.M. (Nico M.) Wulffraat

Full Professor
prof. dr. N.M. (Nico M.) Wulffraat
  • Cluster B
  • Rheumatology Research 1
  • Immunology



Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.

Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.

He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.

Side Activities

Coördinator ERN/RITA 2019 - heden

Commissie lid ZONMW Translationeel Adult Stamcelresearch

Commissielid ZONMW call Priority Medicins Children, thans Goed gebruik Geneesmiddelen

Editor Werkboek Kinderreumatologie

Werkgroep uveitis richtlijn (Orde medisch specialisten, 2014-2015)

Lid Drug safety Monitoring Board Sycamore trial (RCT for adalimumab   in JIA associated uveitis).

Lid bestuur Pediatric Rheumatology European Society (PRES, treasurer, 2012-)

Lid bestuur Pediatric Rheumatology International Trials organization (Printo, 2012-)

Editorial board Pediatric Rheumatology Online Journal

Reviewer for all major rheumatology Journals, Blood, Lancet, NEJM

Organiser (PRES representative) and faculty of basic& advanced educational courses in pediatric Rheumatology (India, Turkey, Brasilia)

Fellowship and Awards

FP7 Grant Pharmachild


Div. ZON MW Grants



AbbVie (bijdrage Reuma2Go)

Roche (bijdrage Reuma2Go)

ERN coordinator RITA

ZonMW grant Chronic Fatique QFS and JIA

Research Output (584)

Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in patients with juvenile dermatomyositis:a real-world multicentre study

Grein Ingrid Herta Rotstein, Pinto Natalia Balera Ferreira, Groot Noortje, Martins Camila Bertini, Lobo Aline, Aikawa Nadia Emi, Barbosa Cassia, Terreri Maria Teresa, da Fraga Aline Coelho Moreira, de Oliveira Sheila Knupp Feitosa, Sztajnbok Flavio, Paim Marques Luciana B, Islabão Aline Garcia, Appenzeller Simone, Bica Blanca, de Oliveira Sato Juliana, Magalhães Claudia Saad, Ferriani Virgínia, Pasmans Hella, Schepp Rutger, van der Klis Fiona, de Roock Sytze, Wulffraat Nico, Pileggi Gecilmara Salviato 11 nov 2020, In: Pediatric rheumatology online journal. 18 , p. 1-12

Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis

Wennink Roos A.W., Pandit Aridaman, Haasnoot Anne Mieke J.W., Hiddingh Sanne, Kalinina Ayuso Viera, Wulffraat Nico M., Vastert Bas J., Radstake Timothy R.D.J., de Boer Joke H., Kuiper Jonas J.W. 17 sep 2020, In: Frontiers in Immunology. 11

Efficacy and Safety of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis With and Without Fever at Baseline:Results from an Open-label, Active Treatment Extension Study

Brunner Hermine I, Quartier Pierre, Alexeeva Ekaterina, Constantin Tamàs, Koné-Paut Isabelle, Marzan Katherine, Schneider Rayfel, Wulffraat Nico M, Chasnyk Vyacheslav, Tirosh Irit, Kallinich Tilmann, Kuemmerle-Deschner Jasmin, Wouters Carine, Lauwerys Bernard, Nikishina Irina, Trachana Maria, Vougiouka Olga, Martini Alberto, Lovell Daniel J, Levy Jeremy, Vritzali Eleni, Ruperto Nicolino, 10 jul 2020, In: Arthritis & Rheumatology. 72 , p. 2147-2158 12 p.

Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in patients with childhood systemic lupus erythematosus:a real-world interventional multi-centre study

Rotstein Grein Ingrid Herta, Pinto Natalia Ferreira, Lobo Aline, Groot Noortje, Sztajnbok Flavio, da Silva Clóvis Artur Almeida, Paim Marques Luciana B., Appenzeller Simone, Islabão Aline Garcia, Magalhães Claudia Saad, de Almeida Rozana Gasparello, Bica Blanca, Fraga Melissa, da Fraga Aline Coelho Moreira, dos Santos Maria Carolina, Robazzi Teresa, Terreri Maria Teresa RA, Bandeira Marcia, Pasmans Hella, Schepp Rutger, van der Klis Fiona, de Roock Sytze, Wulffraat Nico, Pileggi Gecilmara 1 jul 2020, In: Lupus. 29 , p. 934-942 9 p.

The Patient and Parent Perspective on Methotrexate in Recent Juvenile Idiopathic Arthritis Guidelines:Comment on the Article by Ringold et al

Schoemaker Casper G., Wulffraat Nico M., Vastert Sebastiaan J. 1 jun 2020, In: Arthritis and Rheumatology. 72 , p. 1039-1040 2 p.

Treating juvenile idiopathic arthritis to target:What is the optimal target definition to reach all goals?

Schoemaker Casper G., Swart Joost F., Wulffraat Nico M. 16 apr 2020, In: Pediatric Rheumatology. 18 , p. 1-4

European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides – the SHARE initiative:This is a correction to: Rheumatology, Volume 58, Issue 4, April 2019, Pages 656–671,

De Graeff Nienke, Groot Noortje, Brogan Paul, Ozen Seza, Avcin Tadej, Bader-Meunier Brigitte, Dolezalova Pavla, Feldman Brian M., Kone-Paut Isabelle, Lahdenne Pekka, Marks Stephen D., McCann Liza, Pilkington Clarissa, Ravelli Angelo, Van Royen Annet, Uziel Yosef, Vastert Bas, Wulffraat Nico, Kamphuis Sylvia, Beresford Michael W. apr 2020, In: Rheumatology (United Kingdom). 59 , p. 919 1 p.

Pharmacological conditioning for juvenile idiopathic arthritis:A potential solution to reduce methotrexate intolerance

Smits Rosanne M., Veldhuijzen Dieuwke S., Van Middendorp Henriet, Hissink Muller Petra C.E., Armbrust Wineke, Legger Elizabeth, Wulffraat Nico M., Evers Andrea W.M. 7 feb 2020, In: Pediatric Rheumatology. 18 , p. 1-7

Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases:updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE)

Sharrack Basil, Saccardi Riccardo, Alexander Tobias, Badoglio Manuela, Burman Joachim, Farge Dominique, Greco Raffaella, Jessop Helen, Kazmi Majid, Kirgizov Kirill, Labopin Myriam, Mancardi Gianluigi, Martin Roland, Moore John, Muraro Paolo, Rovira Montserrat, Sormani Maria Pia, Snowden John A., Snowden John, Saccardi Riccardo, McGrath Eoin, Bambi Franco, Sanchez-Guijo Fermín, Worel Nina, Snowden John, Alexander Tobias, Badolglio Manuela, Abinun Mario, Arnold Renate, Brierley Charlotte, Castilla-Llorente Cristina, Cooper Nichola, Daikeler Thomas, del Papa Nicoletta, Farge Dominique, Finke Jurgen, Greco Raffaella, Hagglund Hans, Henes Joerg, Hiepe Falk, Jessop Helen, Kiely David, Labopin Myriam, Kazmi Majid, Kirgizov Kirill, Mancardi Gianluigi, Marjanovic Zora, Martin Roland, Martin Thierry, Wulffraat Nico, feb 2020, In: Bone Marrow Transplantation. 55 , p. 283-306

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet