dr. F.G. (Monique) Walet

dr. F.G. (Monique) Walet

Full Professor
dr. F.G. (Monique) Walet
  • Department of Hematology



Prof Dr Monique Minnema was trained as internist and hematologist at Academic Medical Center, Amsterdam and the University Medical Center, Utrecht. She started working as a hematologist in 2005 at the department of hematology, UMC Utrecht and was appointed full professor in 2019. She is specialized in the diagnosis and treatment of B cell malignancies, especially plasma cell dyscrasis  like Multiple Myeloma and AL amyloidosis, and Waldenstrom Macroglobulinemia. Prof Minnema is author on several national and internatonial quidelines on the diagnosis and treatment of these diseases.
She is head supervisor of the hematology clinical research team, the hematology biobank and the European expertise reference network (ERN) malignant hematology of the UMC Utrecht. Her main focus of clinical research is the development of novel therapies (both cellular and drug) developments for plasma cell dyscrasias 

Prof Dr Minnema is an active member of the HOVON working parties for Multiple
Myeloma, Lymphoma, IEC and the vice president of the Lunenburg Lymphoma consortium (LLPC) for phase I/II studies. Examples of her work are the HOVON 104 trial for
patients with AL amyloidosis first line treatment, the clinical studies with
the monoclonal antibody Daratumumab in relapsed Multiple Myeloma and newly diagnosed AL amyloidosis and anti CD19 CAR T cells in relapsed Lymphoma.
Her translational research focuses on 3D models to predict response to therapy and the use of combined immunotherapy for relapsed multiple myeloma.

She was a member of the organizing committee of the Waldenström workshop in Amsterdam in 2016, and is co initiator of the yearly Immune Effector Cell and the Systemic Amyloidosis symposia. 

Side Activities


  • NIV
  • NVvH
  • ASH
  • EHA

Board activities:

  • 2006 onwards: member HOVON working party multiple myeloma, lymphoma, LLPC and Immune Effector Cell (IEC)
  • 2014 onwards: board member Nederlandse Vereniging van Hematologie
  • 2019 onwards: program committee yearly Symposium on Systemic Amyloidosis and Symposium IEC
  • 2019 onwards: Women in Lymphoma steering committee (international)
  • 2021-2022: lid ZonMw beoordelingscommissie
  • 2022 onwards: lid KWF beoordelingscommissie Ontwikkeling en Implementatie
  • May – Nov 2022: lid structuurcommissie van de leerstoel ‘Antistoftherapie’ 
  • May 2022 onwards: bestuurslid HOVON Myeloom WG 
  • August 2022 onwards: member MPE’s Medical Advisory Committee
  • Sept 2022 onwards: member steering committee Aquarius trial
  • Sept 2022 onwards: member IWMF Scientific Advisory Sub-Committee on the Waldenstrom’s Macroglobulinemia (WM) Global Awareness Building Initiative
  • Oct 2022: Member International Myeloma Working Group 

Conflicts of interest:

  • 2022: paid to institution, consultancy Jansen Cilag, BMS, GSK. speakers bureau Binding Site
  • 2021: paid to institution, speakers bureau Medscape, paid to institution consultancy Jansen Cilag
  • 2020: paid to institution, speakers bureau Celgene, paid to institution consultancy Jansen Cilag
  • 2019: paid to institution, speakers bureau Gilead, paid to institution consultancy Alnylam, paid to person; Hospitality Celgene
  • 2018: paid to institution, speakers bureau Roche, Gilead, Celgene, paid to institution consultancy Takeda, Jansen Cilag, paid to person; Hospitality Celgene

Stichting Transparantieregister Zorg - Home, BIG 59043578201

Research Output (152)

Increased mortality risk in multiple-myeloma patients with subsequent malignancies:a population-based study in the Netherlands

Brink Mirian, Minnema Monique C, Visser Otto, Levin Mark-David, Posthuma Eduardus F M Ward, Broijl Annemiek, Sonneveld Pieter, van der Klift Marjolein, Roeloffzen Wilfried W H, Westerman Matthijs, van Rooijen Cleo R, Geerts Paul A F, Zweegman Sonja, van de Donk Niels W C J, Dinmohamed Avinash G 15 Mar 2022, In: Blood cancer journal. 12 , p. 1-4

Pomalidomide in Patients With Relapsed and/or Refractory Multiple Myeloma:A Prospective Study Within the Nationwide Netherlands Cancer Registry

Wester Ruth, Dinmohamed Avinash G, van der Holt Bronno, Zweegman Sonja, Minnema Monique, Croockewit Sandra, Levin Mark-David, Libourel Eduard, de Waal Esther, Sonneveld Pieter, Cornelissen Jan, Blijlevens Nicole, Broijl Annemiek Feb 2022, In: HemaSphere. 6 , p. 1-6

Daratumumab after allogeneic hematopoietic cell transplantation for multiple myeloma is safe and synergies with pre-existing chronic graft versus host disease. A retrospective study from the CMWP EBMT

Vincent Laure, Gras Luuk, Ceballos Patrice, Finke Jürgen, Passweg Jakob, Harel Stéphanie, Rosinol Laura, Minnema Monique, Teipel Raphael, van Doesum Jaap, Hänel Mathias, Lenain Pascal, Botella-Garcia Carmen, Koenecke Christian, Ducastelle Sophie, Sanz Jaime, Schroyens Wilfried, Zuckerman Tsila, Monaco Federico, Koster Linda, de Wreede Liesbeth, Hayden Patrick J, Schönland Stefan, Yakoub-Agha Ibrahim, Beksac Meral 10 Jan 2022, In: Bone Marrow Transplantation. 57 , p. 499-501 3 p.

Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma

Bishop Michael R, Dickinson Michael, Purtill Duncan, Barba Pere, Santoro Armando, Hamad Nada, Kato Koji, Sureda Anna, Greil Richard, Thieblemont Catherine, Morschhauser Franck, Janz Martin, Flinn Ian, Rabitsch Werner, Kwong Yok-Lam, Kersten Marie J, Minnema Monique C, Holte Harald, Chan Esther H L, Martinez-Lopez Joaquin, Müller Antonia M S, Maziarz Richard T, McGuirk Joseph P, Bachy Emmanuel, Le Gouill Steven, Dreyling Martin, Harigae Hideo, Bond David, Andreadis Charalambos, McSweeney Peter, Kharfan-Dabaja Mohamed, Newsome Simon, Degtyarev Evgeny, Awasthi Rakesh, Del Corral Christopher, Andreola Giovanna, Masood Aisha, Schuster Stephen J, Jäger Ulrich, Borchmann Peter, Westin Jason R 14 Dec 2021, In: The New England journal of medicine. 386 , p. 629-639 11 p.

Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma

Locke Frederick L, Miklos David B, Jacobson Caron A, Perales Miguel-Angel, Kersten Marie-José, Oluwole Olalekan O, Ghobadi Armin, Rapoport Aaron P, McGuirk Joseph, Pagel John M, Muñoz Javier, Farooq Umar, van Meerten Tom, Reagan Patrick M, Sureda Anna, Flinn Ian W, Vandenberghe Peter, Song Kevin W, Dickinson Michael, Minnema Monique C, Riedell Peter A, Leslie Lori A, Chaganti Sridhar, Yang Yin, Filosto Simone, Shah Jina, Schupp Marco, To Christina, Cheng Paul, Gordon Leo I, Westin Jason R, 11 Dec 2021, In: The New England journal of medicine. 386 , p. 640-654 15 p.

Targeting B-cell maturation antigen increases sensitivity of multiple myeloma cells to MCL-1 inhibition

Cuenca Marta, Van Nieuwenhuijzen Niels, Moesbergen Laura M, Bloem Andries, Minnema Monique C, Peperzak Victor 9 Dec 2021, In: Haematologica. 107 , p. 980-983 4 p.

Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands:a population-based study

Brink Mirian, Groen Kaz, Sonneveld Pieter, Minnema Monique C, Broijl Annemiek, Dinmohamed Avinash G, van der Spek Ellen, Levin Mark-David, Ypma Paula F, de Waal Esther, Posthuma Eduardus F M Ward, Zweegman Sonja, van de Donk Niels W C J 11 Nov 2021, In: Blood cancer journal. 11 , p. 1-7

Efficacy and Safety of Daratumumab Combined With All-Trans Retinoic Acid in Relapsed/Refractory Multiple Myeloma

Frerichs Kristine A, Minnema Monique Christina, Levin Mark-David, Broijl Annemiek, Bos Gerard Mj, Kersten Marie José, Mutis Tuna, Verkleij Christie P M, Nijhof Inger S, Maas-Bosman Patty W C, Klein Saskia K, Zweegman Sonja, Sonneveld Pieter, van de Donk Niels W C J 8 Oct 2021, In: Blood Advances. 5 , p. 5128-5139 12 p.

Earlier corticosteroid use for adverse event management in patients receiving axicabtagene ciloleucel for large B-cell lymphoma

Topp Max S, van Meerten Tom, Houot Roch, Minnema Monique C, Bouabdallah Krimo, Lugtenburg Pieternella J, Thieblemont Catherine, Wermke Martin, Song Kevin W, Avivi Irit, Kuruvilla John, Dührsen Ulrich, Zheng Yan, Vardhanabhuti Saran, Dong Jinghui, Bot Adrian, Rossi John M, Plaks Vicki, Sherman Marika, Kim Jenny J, Kerber Anne, Kersten Marie José 29 Sep 2021, In: British Journal of Haematology. 195 , p. 388-398 11 p.

Consolidation and Maintenance in Newly Diagnosed Multiple Myeloma

Sonneveld Pieter, Dimopoulos Meletios A, Beksac Meral, van der Holt Bronno, Aquino Sara, Ludwig Heinz, Zweegman Sonja, Zander Thilo, Zamagni Elena, Wester Ruth, Hajek Roman, Pantani Lucia, Dozza Luca, Gay Francesca, Cafro AnneMaria, De Rosa Luca, Morelli Annamaria, Gregersen Henrik, Gulbrandsen Nina, Cornelisse Petra, Troia Rosella, Oliva Stefania, van de Velden Vincent, Wu KaLung, Ypma Paula F, Bos Gerard, Levin Mark-David, Pour Luca, Driessen Christoph, Broijl Annemiek, Croockewit Alexandra, Minnema Monique C, Waage Anders, Hveding Cecilie, van de Donk Niels W C J, Offidani Massimo, Palumbo Giuseppe A, Spencer Andrew, Boccadoro Mario, Cavo Michele 14 Sep 2021, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 39 , p. 3613-3622 10 p.

All research output

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