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dr. H.M. van Santen

dr. H.M. van Santen

Associate Professor - medical
dr. H.M. van Santen
  • Endocrinology patient care

Biography

Biography

Dr. HM van Santen moved her career in 2013 to Utrecht to support the Máxima initiative and to coordinate the endocrine care for children with cancer in the Princess Máxima Center. 

She has co-authored > 100 articles on the endocrine effects of childhood cancer treatment, craniopharyngioma and pediatric thyroid cancer.

She is an associate professor, PI and clinical scientist in the research program of Child Health, WKZ, UMCU and co-PI in the Máxima Center for Pediatric Oncology. 

Her research program focuses on the endocrine and metabolic effects of children with severe disease such as childhood craniopharyngioma, the acute and late effects of childhood cancer treatment on the endocrine system, and on pediatric thyroid cancer. The overall aim of her work is to preserve an intact endocrine system in children with neoplasms enabling normal growth and development into adulthood.

She is chair of the SIOPe craniopharyngioma working group and of the MC4 group Craniopharyngioma in the Máxima Center for Pediatric Oncology. Also she chairs the Late Effects of Childhood Cancer International Guideline Harmonization Groups (IGHG) for thyroid and hypothalamic-pituitary disorders, and is member of the IGHG working groups for male and female gonadal toxicity and preservation of fertility and metabolic syndrome.

She is chair of the Dutch and the European Guideline for Thyroid cancer in children (ETA) and the coordinator of the NFU/ ENDO-ERN expertise center Thyroid Tumors in Utrecht.

Furthermore, Dr Hm van Santen is a member of the SIOP low grade glioma working group, the national consortium for Late effects of treatment for childhood thyroid carcinoma, the consortium of the Dexadagen-2 study, the Dutch Growth Hormone Advisory board and has a consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma.

Side Activities

2020 - now   member of the WKZ Onderzoeksfonds Scientific Committee

2020             member of the Internal Grant committee Princess Maxima Center

2020             Chair SIOPe craniopharyngioma board

2020             Member of the Advisory board of the Academic Japanese Consortium for Juvenile Thyroid Cancer (JCJTC, president Dr Ohtsuru)  

2020             co-PI Prinses Maxima Center for Pediatric Oncology Utrecht

2019             BKO qualification UMCU

2019             Chair of the European Task Force for Recommendations of Treatment of Thyroid nodules and Carcinoma in Childhood

2016 – now  Deputy educator ( plaatsvervangend opleider) of the clinical fellow pediatric endocrinology in the Wilhelmina Children’s Hospital, UMCU

2018 - now   member of working group supportive care Princess Maxima Center

2017 - now   member of fertility working group Princess Maxima Center

2016 - now   Co-chair of the IGHG for surveillance of hypothalamic-pituitary disorders in Childhood Cancer Survivors

2016 - now   Participant/ member of the working group of the IGHG working group for  preservation of fertility in male childhood cancer survivors (in progress)

2016 – now  Participant / working group lead of the IGHG working group for preservation of fertility in female childhood cancer survivors (in progress)

2016 - now   Participant/ member of the working group of the IGHG recommendation for surveillance of the metabolic syndrome in childhood cancer survivors (in progress)

2016 - now   Co-chair of the Dutch Guideline for Treatment of Thyroid nodules and cancer in children (in progress)

2016 - now   Participant of  the SIOP supportive care group

2016 - now   Participant of the SIOP low grade glioma working group

2016 - now   Participant of the national consortium for Late effects of treatment for childhood thyroid carcinoma ( PI T Links, UMCG)

2016 - now   Participant of the consortium of the Dexadagen-2 study

2015 - now   Participant of the Dutch Growth Hormone Advisory board (SEK)

2015 - now   Consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma(www.cyberpoli.nl)

 2015 – now    Participant of the SKION LATER Recommendations for screening Childhood Cancer Survivors https://www.skion.nl/workspace/uploads/vertaling-richtlijn-LATER-versie-final-okt-2014_2.pdf

 

Fellowship and Awards

2020                ZonMW Stimuleringssubsidie "Implementatie van nieuw behandelalgoritme voor hypothalame obesitas bij kinderen met een supra-sellaire tumor"

2019                KIKA project: THYRO-Dynamics Study (Prospective study on thyroid function during treatment with chemotherapy in 600 children)

2019                Princess Maxima Grant; research grant for 4-year PhD student: “Building an organoid model for craniopharyngioma”

2009-2011      Fellowship kinderendocrinologie in het Emma Kinderziekenhuis AMC

Research Output (114)

Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism

van der Vaart Jelte, Bosmans Lynn, Sijbesma Stijn F, Knoops Kèvin, van de Wetering Willine J, Otten Henny G, Begthel Harry, Borel Rinkes Inne H M, Korving Jeroen, Lentjes Eef G W M, Lopez-Iglesias Carmen, Peters Peter J, van Santen Hanneke M, Vriens Menno R, Clevers Hans 21 Dec 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118 , p. 1-11

Overweight in the Dutch National Cohort of Long-Term Survivors of Childhood Cancer

Pluimakers Vincent, Van Atteveld Jenneke E., de Winter Demi T.C., Fiocco M., Nievelstein Rutger Jan, Bresters Dorine, van der Heiden-van der Loo Margriet, de Vries Andrica C, Janssens Geert O, Louwerens Marloes, van der Pal Helena J H, Ronckers Cécile, van Santen HM, Versluijs Birgitta, Kremer Leontien, Loonen Jacqueline J, Tissing Wim, Van Dulmen-Den Broeder Eline, van den Heuvel-Eibrink M.M., Neggers Sebastian J C M M 23 Nov 2021, In: Blood. 138 , p. 3054-3055

Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma:a longitudinal follow-up study

Dekker Bernadette L, Muller Kobold Anneke C, Brouwers Adrienne H, Williams Graham R R, Nies Marloes, Klein Hesselink Mariëlle Sanne, van der Horst-Schrivers Anouk N A, Havekes Bas, van den Heuvel-Eibrink Marry M, van der Pal Heleen J H, Plukker John Th M, Ronckers Cecile M, van Santen Hanneke M, Burgerhof Johannes G M, Corssmit Eleonora P M, Netea-Maier Romana, Peeters Robin P, van Dam Eveline W C M, Boot Annemieke, Tissing Wim J E, Bocca Gianni, Links Thera P 8 Oct 2021, In: Thyroid. 31 , p. 1707-1714 8 p.

Opposite incidence trends for differentiated and medullary thyroid cancer in young dutch patients over a 30‐year time span

Lebbink Chantal A., van den Broek Medard F.M., Kwast Annemiek B.G., Derikx Joep P.M., Dierselhuis Miranda P., Kruijff Schelto, Links Thera P., van Trotsenburg A. S.Paul, Valk Gerlof D., Vriens Menno R., Verrijn Stuart Annemarie A., van Santen Hanneke M., Karim‐kos Henrike E. 2 Oct 2021, In: Cancers. 13

Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group

Bakhuizen Jette J., Hanson Helen, van der Tuin Karin, Lalloo Fiona, Tischkowitz Marc, Wadt Karin, Jongmans Marjolijn C.J., , , , van Santen HM 1 Oct 2021, In: Familial cancer. 20 , p. 337-348 12 p.

Prevalence and risk factors of hypothalamic-pituitary dysfunction in infant and toddler childhood brain tumor survivors

Lebbink C. A., Ringers T. P., Schouten-van Meeteren A. Y.N., van Iersel L., Clement S. C., Boot A. M., Claahsen-van der Grinten H. L., Janssens G. O., van Vuurden D. G., Michiels E. M., Han K. S., van Trotsenburg A. S.P., Vandertop W. P., Kremer L. C.M., van Santen H. M. 6 Sep 2021, In: European Journal of Endocrinology. 185 , p. 597-606 10 p.

Children with multiple endocrine neoplasia type 2B:Not tall and marfanoid, but short with normal body proportions

van den Broek Medard F M, van Santen Hanneke M, Valk Gerlof D, Verrijn Stuart Annemarie A 23 Jun 2021, In: Clinical Endocrinology. 95 , p. 453-459 7 p.

Echocardiography protocol for early detection of cardiac dysfunction in childhood cancer survivors in the multicenter DCCSS LATER 2 CARD study:Design, feasibility, and reproducibility

Merkx Remy, Leerink Jan M., Feijen Elisabeth A.M., Kremer Leontien C.M., de Baat Esmée C., Bellersen Louise, van Dalen Elvira C., van Dulmen-den Broeder Eline, van der Heiden-van der Loo Margriet, van den Heuvel-Eibrink Marry M., Korte Chris L.de, Loonen Jacqueline, Louwerens Marloes, Maas Angela H.E.M., Pinto Yigal M., Ronckers Cécile M., Teske Arco J., Tissing Wim J.E., de Vries Andrica C.H., Mavinkurve-Groothuis Annelies M.C., van der Pal Helena J.H., Weijers Gert, Kok Wouter E.M., Kapusta Livia, Versluys Birgitta, Grootenhuis Martha, van Leeuwen Flora, Neggers Sebastian, van der Steeg Lideke, Janssens Geert, van Santen Hanneke, Veening Margreet, den Hartogh Jaap, Pluijm Saskia, Batenburg Lilian, de Ridder Hanneke, Hollema Nynke, Teunissen Lennart, Schellekens Anke, Jun 2021, In: Echocardiography. 38 , p. 951-963 13 p.

Growth Patterns in Children With Multiple Endocrine Neoplasia Type 2B: Small Stature in Childhood

van den Broek Medard, van Santen HM, Valk GD, Verrijn Stuart Annemarie A 20 Mar 2021,

Oncofertility care for newly diagnosed girls with cancer in a national pediatric oncology setting, the first full year experience from the Princess Maxima Center, the PEARL study

Madeleine van der Perk M. E., van der Kooi Anne Lotte L.F., van de Wetering Marianne D., IJgosse Irene M., van Dulmen-Den Broeder Eline, Broer Simone L., Klijn Aart J., Versluys A. Birgitta, Arends Brigitte, Oude Ophuis Ralph J.A., van Santen Hanneke M., van der Steeg Alida F.W., Veening Margreet A., van den Heuvel-Eibrink Marry M., Bos Annelies M.E. 5 Mar 2021, In: PLoS ONE. 16 , p. 1-18

All research output

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