prof. dr. J.M. (Jaap) van Laar

prof. dr. J.M. (Jaap) van Laar

Full Professor
prof. dr. J.M. (Jaap) van Laar
  • Rheumatology & Clinical Immunology



Jacob M. van Laar is Professor at the Department of Rheumatology and Clinical Immunology at UMC Utrecht, the Netherlands. After obtaining his MD and PhD degrees at Leiden University, he specialised in Internal Medicine and Rheumatology in Leiden University Medical Center and worked at the Department of Rheumatology as clinical academic in various roles from 1997-2007, interrupted by a postdoctoral research fellowship at the National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, USA. From 2007 until 2013 he held a Chair in Clinical Rheumatology at Newcastle University, and post as honorary consultant rheumatologist at The James Cook University Hospital, Middlesbrough, UK. He has been working as Professor of Rheumatology at UMC Utrecht since 1 November 2013. His main research interests involve clinical and pathogenetic aspects of systemic sclerosis and rheumatoid arthritis, aimed at improving the outcome of patients with rheumatic diseases by innovative clinical-translational research.

Side Activities

Member EULAR Scientific Programme Committee (2018 - present)

Ad hoc expert advice Central Board of Appeal (2018 - present)

Chairman Concilium Dutch Society for Rheumatology (2014-present)

Founding Member Stichting ARCH (2017-present)

Member Scientific Advisory Board Edith Busch Stiftung (2015-present)

Member of EUSTAR (EULAR Scleroderma Trials and Research) (2007-present) 

Ad hoc consultant for pharmaceutical companies (2013 - present)

Chair Society for Rheumatology Research Utrecht (2013 - 2019)


Fellowship and Awards

Marie Parijs prijs for pioneering work in the field of clinical stem cell research in rheumatic autoimmune diseases (2002, Leiden University Medical Center)

ZonMW Clinical Fellow (2007)

Fellow of the Royal College of Physicians Edinburgh (2009)

Research Output (275)

A randomised, open-label trial to assess the optimal treatment strategy in early diffuse cutaneous systemic sclerosis:the UPSIDE study protocol

Spierings Julia, van Rhenen Anna, Welsing Paco Mw, Marijnissen Anne Ca, De Langhe Ellen, Del Papa Nicoletta, Dierickx Daan, Gheorghe Karina R, Henes Joerg, Hesselstrand Roger, Kerre Tessa, Ljungman Per, van de Loosdrecht Arjan A, Marijt Erik Waf, Mayer Miro, Schmalzing Marc, Schroers Roland, Smith Vanessa, Voll Reinhard E, Vonk Madelon C, Voskuyl Alexandre E, de Vries-Bouwstra Jeska K, Walker Ulrich A, Wuttge Dirk M, van Laar Jacob M 18 mrt 2021, In: BMJ Open. 11 , p. e044483

EULAR definition of difficult-to-treat rheumatoid arthritis

Nagy György, Roodenrijs Nadia Mt, Welsing Paco Mj, Kedves Melinda, Hamar Attila, van der Goes Marlies C, Kent Alison, Bakkers Margot, Blaas Etienne, Senolt Ladislav, Szekanecz Zoltan, Choy Ernest, Dougados Maxime, Jacobs Johannes Wg, Geenen Rinie, Bijlsma Hans Wj, Zink Angela, Aletaha Daniel, Schoneveld Leonard, van Riel Piet, Gutermann Loriane, Prior Yeliz, Nikiphorou Elena, Ferraccioli Gianfranco, Schett Georg, Hyrich Kimme L, Mueller-Ladner Ulf, Buch Maya H, McInnes Iain B, van der Heijde Désirée, van Laar Jacob M jan 2021, In: Annals of the Rheumatic Diseases. 80 , p. 31-35 5 p.

From “being at war” to “getting back on your feet”:A qualitative study on experiences of patients with systemic sclerosis treated with hematopoietic stem cell transplantation

Spierings Julia, de Bresser Carolijn J.M., van Rhijn-Brouwer Femke C.C., Pieterse Arwen, Vonk Madelon C., Voskuyl Alexandre E., de Vries-Bouwstra Jeska K., van Laar Jacob M., Kars Marijke C. okt 2020, In: Journal of Scleroderma and Related Disorders. 5 , p. 202-209

Tocilizumab in systemic sclerosis:a randomised, double-blind, placebo-controlled, phase 3 trial

Khanna Dinesh, Lin Celia J F, Furst Daniel E, Goldin Jonathan, Kim Grace, Kuwana Masataka, Allanore Yannick, Matucci-Cerinic Marco, Distler Oliver, Shima Yoshihito, van Laar Jacob M, Spotswood Helen, Wagner Bridget, Siegel Jeffrey, Jahreis Angelika, Denton Christopher P, okt 2020, In: The Lancet Respiratory Medicine. 8 , p. 963-974 12 p.

CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cellsin vitro

Silva-Cardoso Sandra C., Tao Weiyang, Angiolilli Chiara, Lopes Ana P., Bekker Cornelis P. J., Devaprasad Abhinandan, Giovannone Barbara, van Laar Jaap, Cossu Marta, Marut Wioleta, Hack Erik, de Boer Rob J., Boes Marianne, Radstake Timothy R. D. J., Pandit Aridaman 17 sep 2020, In: Frontiers in Immunology. 11

Effectiveness and safety over 3 years after the 2-year U-Act-Early trial of the strategies initiating tocilizumab and/or methotrexate

Verhoeven Maxime M.A., Tekstra Janneke, Welsing Paco M.J., Pethö-Schramm Attila, Borm Michelle E.A., Bruyn George A.W., Bos Reinhard, Griep Ed N., Klaasen Ruth, van Laar Jacob M., Lafeber Floris P.J.G., Bijlsma Johannes W.J., de Hair Marjolein J.H., Jacobs Johannes W.G. 1 sep 2020, In: Rheumatology (Oxford, England). 59 , p. 2325-2333 9 p.

B(effector)reaking bad in systemic sclerosis:role of a novel B cell subset

O'Reilly S, van Laar J sep 2020, In: Clinical and Experimental Immunology. 201 , p. 231-232 2 p.

Predictive factors for treatment-related mortality and major adverse events after autologous haematopoietic stem cell transplantation for systemic sclerosis:results of a long-term follow-up multicentre study

van Bijnen Sandra, de Vries-Bouwstra Jeska, van den Ende Cornelia H, Boonstra Maaike, Kroft Lucie, Geurts Bram, Snoeren Miranda, Schouffoer Anne, Spierings Julia, van Laar Jacob M, Huizinga Tom Wj, Voskuyl Alexandre, Marijt Erik, van der Velden Walter, van den Hoogen Frank Hj, Vonk Madelon C aug 2020, In: Annals of the Rheumatic Diseases. 79 , p. 1084-1089 6 p.

Clinical practice guidelines adherence, knowledge and awareness in rare and complex connective tissue diseases across Europe:results from the first ERN ReCONNET survey

Talarico Rosaria, Marinello Diana, Bombardieri Stefano, Burmester Gerd, Fonseca Joao, Frank Charissa, Galetti Ilaria, Hachulla Eric, Houssiau Frederic, Mueller-Ladner Ulf, Schneider Matthias, Smith Vanessa, Turchetti Giuseppe, van Laar Jacob M, Vieira Ana, Cutolo Maurizio, Mosca Marta aug 2020, In: RMD Open. 6 , p. 1-12

Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA):a double-blind, multicentre, randomised controlled trial

Burmester Gerd R, Buttgereit Frank, Bernasconi Corrado, Álvaro-Gracia Jose M, Castro Nidia, Dougados Maxime, Gabay Cem, van Laar Jacob M, Nebesky Jan Michael, Pethoe-Schramm Attila, Salvarani Carlo, Donath Marc Y, John Markus R, 25 jul 2020, In: The Lancet. 396 , p. 267-276 10 p.

All research output

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