prof. dr. C.K. (Cornelis) van der Ent

prof. dr. C.K. (Cornelis) van der Ent

Full Professor
prof. dr. C.K. (Cornelis) van der Ent
  • Pulmonology patient care
  • Speerpunt Child Health



The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.

Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.

Side Activities

Chairman of Cystic Fibrosis Center Utrecht

Chairman of Dutch Cystic Fibrosis Research Network

Member of Medical Advisory Board Dutch Cystic Fibrosis Committee

Member of Research committee Wilhelmina Children’s Hospital Utrecht

Member of Medical Ethical Committee University Medical Center Utrecht

Medical advisor of Sioux CCM

Board Member of Malawi Mission Work Team

Reviewer for Am J Resp Crit Care Med, European Respir J and many others


Fellowship and Awards

European CF young investigator meeting award 2011. A functional CFTR assay using primary cystic fibrosis organoids

European CF basic science meeting award 2011. Treatment with VX809 and VX770 in rectal CF organoids expressing  uncommon CFTR genotypes

European CF basic science meeting award 2012. Characterizing altered inflammatory signaling in CFTR-defective

bronchial epithelial cells

National symposium Dutch CF foundation award 2011. Complement mediated phagocytosis is reduced in CF monocytes.

Research Output (507)

Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation

Berkers Gitte, van der Meer Renske, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Suen Sylvia Wf, Heijerman Harry Gm, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Janssens Hettie M, de Rijke Yolanda B, Kemper E Marleen, Beekman Jeffrey M, van der Ent Cornelis K, de Jonge Hugo R nov 2020, In: Journal of Cystic Fibrosis. 19 , p. 955-961 7 p.

Defining asthma in children:how well do parents, doctors and spirometry agree?

Korsten Koos, Naaktgeboren Christiana A, Bont Louis J, van der Ent Cornelis K, de Hoog Marieke L A okt 2020, In: ERJ Open Research. 6 , p. 1-10

R117H-CFTR function and response to VX-770 correlate with mRNA and protein expression in intestinal organoids

Van Mourik Peter, van Haaren Paul, Kruisselbrink Evelien, Korkmaz Cemil, Janssens Hettie M., de Winter – de Groot Karin M., van der Ent Cornelis K., Hagemeijer Marne C., Beekman Jeffrey M. sep 2020, In: Journal of Cystic Fibrosis. 19 , p. 728-732 5 p.

Risk factors for atopic diseases and recurrent respiratory tract infections in children

Kansen Hannah M, Lebbink Melanie A, Mul Joeri, van Erp Francine C, van Engelen Martine, de Vries Esther, Prevaes Sabine M P J, Le Thuy My, van der Ent Cornelis K, Verhagen Lilly M 25 aug 2020, In: Pediatric Pulmonology. 55 , p. 3168-3179 12 p.

Relative hyperventilation in non-ventilated patients with spinal muscular atrophy

Veldhoen Esther S, Wijngaarde Camiel A, Verweij-van den Oudenrijn Laura P, Asselman Fay-Lynn, Wösten-van Asperen Roelie M, Hulzebos Erik H J, van der Ent Kors, Cuppen Inge, Gaytant Michael A, van Eijk Ruben P A, van der Pol W Ludo 25 jun 2020, In: The European respiratory journal. 56

Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids

Vonk Annelotte M, van Mourik Peter, Ramalho Anabela S, Silva Iris A L, Statia Marvin, Kruisselbrink Evelien, Suen Sylvia W F, Dekkers Johanna F, Vleggaar Frank P, Houwen Roderick H J, Mullenders Jasper, Boj Sylvia F, Vries Robert, Amaral Margarida D, de Boeck Kris, van der Ent Cornelis K, Beekman Jeffrey M 19 jun 2020, In: STAR protocols. 1 31 p.

Long-term effects of ivacaftor on nonpulmonary outcomes in individuals with cystic fibrosis, heterozygous for a S1251N mutation

Burghard M., Berkers G., Ghijsen S., Hollander-Kraaijeveld F. M., de Winter-de Groot K. M., van der Ent C. K., Heijerman H. G.M., Takken T., Hulzebos H. J. jun 2020, In: Pediatric Pulmonology. 55 , p. 1400-1405 6 p.

Daily life participation in childhood chronic disease:a qualitative study

Nap-van der Vlist Merel M, Kars Marijke C, Berkelbach van der Sprenkel Emma E, Nijhof Linde N, Grootenhuis Martha A, van Geelen Stefan M, van der Ent Cornelis K, Swart Joost F, van Royen-Kerkhof Annet, van Grotel Martine, van de Putte Elise M, Nijhof Sanne L 1 mei 2020, In: Archives of Disease in Childhood. 105 , p. 463-469 7 p.

Natural history of lung function in spinal muscular atrophy

Wijngaarde Camiel A., Veldhoen Esther S., van Eijk Ruben P.A., Stam Marloes, Otto Louise A.M., Asselman Fay Lynn, Wösten-van Asperen Roelie M., Hulzebos Erik H.J., Verweij-van den Oudenrijn Laura P., Bartels Bart, Cuppen Inge, Wadman Renske I., van den Berg Leonard H., van der Ent Cornelis K., van der Pol W. Ludo 10 apr 2020, In: Orphanet Journal of Rare Diseases. 15 11 p.

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Geurts Maarten H., de Poel Eyleen, Amatngalim Gimano D., Oka Rurika, Meijers Fleur M., Kruisselbrink Evelien, van Mourik Peter, Berkers Gitte, de Winter-de Groot Karin M., Michel Sabine, Muilwijk Danya, Aalbers Bente L., Mullenders Jasper, Boj Sylvia F., Suen Sylvia W.F., Brunsveld Jesse E., Janssens Hettie M., Mall Marcus A., Graeber Simon Y., van Boxtel Ruben, van der Ent Cornelis K., Beekman Jeffrey M., Clevers Hans 2 apr 2020, In: Cell stem cell. 26 , p. 503-510.e7

All research output

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