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dr. X.Y.Y. van der Breen

dr. X.Y.Y. van der Breen

Full Professor
dr. X.Y.Y. van der Breen
  • Neurologen

Research Programs

Biography

Biography

Bart van der Worp is a neurologist with a special interest in cerebrovascular diseases at the University Medical Center in Utrecht, the Netherlands. He has been (co-)Chief Investigator of the randomised stroke trials HAMLET, PAIS, COOLIST, VAST, APACHE-AF, and MR ASAP and is Chief Investigator of PRECIOUS. He is a member of the Dutch CONTRAST consortium which aims to identify and test new treatments for patients with acute ischaemic stroke or intracerebral haemorrhage. He is former President of the European Stroke Organisation.

Side Activities

2008 –          fellow of the European Stroke Organisation (ESO)

2011 – 2022 member of the Board of Directors of ESO

2011 – 2016 member of the Committee for Professional Interests (BBC) of the NVN

2013 – 2015 member of the Committee for Clinical trials of ESO

2013 – 2017 member of the Guideline Committee of ESO

2014 – 2016 vice-president ESO

2014 – 2021 member of the writing committee of the Dutch Stroke Guideline

2016 – 2018 president-elect ESO

2018 – 2020 president ESO

2019 – 2021 member of Committee on emergency prehospital care (45-minutennorm) of the Gezondheidsraad

2019 - 2020 consultant, Bayer

2020 – 2022 past president ESO

2020 – 2021 Chair module writing group ESO guideline on space-occupying oedema

2022 -          consultant, TargED

2022 -          national coordinator randomised trial, Bayer

 

Member of Data and Safety Monitoring Boards of randomised trials

2005 – 2007 Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis

2009 – 2011 Intrathecal methylprednisolone for intractable postherpetic neuralgia: STIP study. (Steroids for Intractable Postherpetic Neuralgia)

2009 – 2011 A randomised sequential trial of Lithium In amyotrophic lateral sclerosis

2015 – 2021 TELSTAR: Treatment of electroencephalographic status epilepticus after cardiopulmonary resuscitation - a randomized controlled trial (Chair)

2018 – 2019 PHALS: A placebo-controlled double blind randomized trial to investigate the efficacy and safety of the combination of Penicillin G / Hydrocortisone treatment in ALS patients (Chair)

2018 –          RESSTORE: Regenerative Stem Cell Therapy for Stroke in Europe

2019 –          GRECO: Ghrelin treatment of comatose patients after cardiac arrest: A phase 2 clinical trial to estimate safety and efficacy of ghrelin to promote cerebral (Chair)

Research Output (209)

Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED):an open-label, multicentre, randomised controlled trial

van der Steen Wouter, van de Graaf Rob A, Chalos Vicky, Lingsma Hester F, van Doormaal Pieter Jan, Coutinho Jonathan M, Emmer Bart J, de Ridder Inger, van Zwam Wim, van der Worp H Bart, van der Schaaf Irene, Gons Rob A R, Yo Lonneke S F, Boiten Jelis, van den Wijngaard Ido, Hofmeijer Jeannette, Martens Jasper, Schonewille Wouter, Vos Jan Albert, Tuladhar Anil Man, de Laat Karlijn F, van Hasselt Boudewijn, Remmers Michel, Vos Douwe, Rozeman Anouk, Elgersma Otto, Uyttenboogaart Maarten, UMC Amsterdam, van Tuijl Julia, Boukrab Issam, van den Berg René, Beenen Ludo F M, Roosendaal Stefan D, Postma Alida Annechien, Krietemeijer Menno, Lycklama Geert, Meijer Frederick J A, Hammer Sebastiaan, van der Hoorn Anouk, Yoo Albert J, Gerrits Dick, Truijman Martine T B, Zinkstok Sanne, Koudstaal Peter J, Manschot Sanne, Kerkhoff Henk, Nieboer Daan, Berkhemer Olvert, Wolff Lennard, van der Sluijs P Matthijs, 12 Mar 2022, In: Lancet (London, England). 399 , p. 1059-1069 11 p.

Impact of the lockdown on acute stroke treatments during the first surge of the COVID-19 outbreak in the Netherlands

Benali Faysal, Stolze Lotte J, Rozeman Anouk D, Dinkelaar Wouter, Coutinho Jonathan M, Emmer Bart J, Gons Rob A R, Yo Lonneke F S, van Tuijl Julia H, Boukrab Issam, van Dam-Nolen Dianne H K, van den Wijngaard Ido R, Lycklama À Nijeholt Geert J, de Laat Karlijn F, van Dijk Lukas C, den Hertog Heleen M, Flach H Zwenneke, Wermer Marieke J H, van Walderveen Marianne A A, Brouwers Paul J A M, Bulut Tomas, Vermeer Sarah E, Bernsen Marie Louise E, Uyttenboogaart Maarten, Bokkers Reinoud P H, Boogaarts Jeroen D, de Leeuw Frank-Erik, van der Worp H Bart, van der Schaaf Irene C, Schonewille Wouter J, Vos Jan A, Remmers Michel J M, Imani Farshad, Dippel Diederik W J, van Zwam Wim H, Nederkoorn Paul J, van Oostenbrugge Robert J 11 Jan 2022, In: BMC Neurology. 22

Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19:A Multicenter Cohort Study

Sluis Wouter M, Linschoten Marijke, Buijs Julie E, Biesbroek J Matthijs, den Hertog Heleen M, Ribbers Tessa, Nieuwkamp Dennis J, van Houwelingen Reinier C, Dias Andreas, van Uden Ingeborg W M, Kerklaan Joost P, Bienfait H Paul, Vermeer Sarah E, de Jong Sonja W, Ali Mariam, Wermer Marieke J H, de Graaf Marieke T, Brouwers Paul J A M, Asselbergs Folkert W, Kappelle L Jaap, van der Worp H Bart, Algra Annemijn M, 4 Nov 2021, In: Stroke. 52 , p. 3978-3986 9 p.

Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF):a randomised, open-label, phase 2 trial

Schreuder Floris H B M, van Nieuwenhuizen Koen M, Hofmeijer Jeannette, Vermeer Sarah E, Kerkhoff Henk, Zock Elles, Luijckx Gert-Jan, Messchendorp Gert P, van Tuijl Julia, Bienfait H Paul, Booij Suzanne J, van den Wijngaard Ido R, Remmers Michel J M, Schreuder Antonia H C M L, Dippel Diederik W, Staals Julie, Brouwers Paul J A M, Wermer Marieke J H, Coutinho Jonathan M, Kwa Vincent I H, van Gelder Isabelle C, Schutgens Roger E G, Zweedijk Berber, Algra Ale, van Dalen Jan Willem, Jaap Kappelle L, Rinkel Gabriel J E, van der Worp H Bart, Klijn Catharina J M, Nov 2021, In: The Lancet. Neurology. 20 , p. 907-916 10 p.

Second asymptomatic carotid surgery trial (ACST-2):a randomised comparison of carotid artery stenting versus carotid endarterectomy

Halliday Alison, Bulbulia Richard, Bonati Leo H., Chester Johanna, Cradduck-Bamford Andrea, Peto Richard, Pan Hongchao, Potter John, Henning Eckstein Hans, Farrell Barbara, Flather Marcus, Mansfield Averil, Mihaylova Boby, Rahimi Kazim, Simpson David, Thomas Dafydd, Sandercock Peter, Gray Richard, Molyneux Andrew, Shearman Cliff P., Rothwell Peter, Belli Anna, Herrington Will, Judge Parminder, Leopold Peter, Mafham Marion, Gough Michael, Cao Piergiorgio, MacDonald Sumaira, Bari Vasha, Berry Clive, Bradshaw S., Brudlo Wojciech, Clarke Alison, Cox Robin, Fathers Susan, Gaba Kamran, Gray Mo, Hayter Elizabeth, Holliday Constance, Kurien Rijo, Lay Michael, Poorthuis Michiel, Schmidt Andrej, de Borst Gert J., Moll Frans L., Toorop Raechel, van der Worp Bart H., Vonken Evert J., Kappelle Jaap L., 18 Sep 2021, In: The Lancet. 398 , p. 1065-1073 9 p.

Hypotension during endovascular treatment under general anesthesia for acute ischemic stroke

Collette Sabine L, Uyttenboogaart Maarten, Samuels Noor, van der Schaaf Irene C, van der Worp H Bart, Luijckx Gert Jan R, Venema Allart M, Sahinovic Marko M, Dierckx Rudi A J O, Lingsma Hester F, Kappen Teus H, Bokkers Reinoud P H, 23 Jun 2021, In: PLoS ONE. 16 , p. 1-16

Intracranial Atherosclerotic Burden and Cerebral Parenchymal Changes at 7T MRI in Patients With Transient Ischemic Attack or Ischemic Stroke

Lindenholz Arjen, de Bresser Jeroen, van der Kolk Anja G, van der Worp H Bart, Witkamp Theodoor D, Hendrikse Jeroen, van der Schaaf Irene C 6 May 2021, In: Frontiers in Neurology. 12 , p. 1-10

Randomised comparison of a balloon-expandable and self-expandable valve with quantitative assessment of aortic regurgitation using magnetic resonance imaging

Kooistra N H M, Abawi M, Voskuil M, Urgel K, Samim M, Nijhoff F, Nathoe H M, Doevendans P A F M, Chamuleau S A J, Leenders G E H, Leiner T, Abrahams A C, van der Worp H B, Agostoni P, Stella P R 3 Apr 2020, In: Netherlands Heart Journal. 28 , p. 253-265 13 p.

Intracranial atherosclerosis assessed with 7-T MRI:Evaluation of patients with ischemic stroke or transient ischemic attack

Lindenholz Arjen, van der Kolk Anja G., van der Schaaf Irene C., van der Worp H. Bart, Harteveld Anita A., Dieleman Nikki, Bots Michiel L., Hendrikse Jeroen Apr 2020, In: Radiology. 295 , p. 162-170 9 p.

MRI Vessel Wall Imaging after Intra-Arterial Treatment for Acute Ischemic Stroke

Lindenholz A, van der Schaaf I C, van der Kolk A G, van der Worp H B, Harteveld A A, Kappelle L J, Hendrikse J Apr 2020, In: American Journal of Neuroradiology. 41 , p. 624-631 8 p.

All research output

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