drs. ing. I.J.J. (Floris) Stapel
drs. ing. I.J.J. (Floris) Stapel
- Birth Center Neonatology - Medical
Research Programs
Biography
Biography
Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.
Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.
In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic strategies have been developed and tested in animal models.
He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.
He is member of many professional societies.
Research line
Neonatal neuroprotection
Most recent key publications
1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575
Side Activities
• Invited speaker on many international courses and symposia
• Co-inventor of 2-iminobiotin for neonatal neuroprotection
• Expert witness in several legal cases
• Reviewer for many international scientific journals
Fellowship and Awards
- Ter Meulen Fonds, KNAW, Amsterdam 1993
- Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995
- NWO AGIKO-stipendium 920-03-039
- Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07
- Dr.W.M.Phelps-Stichting voor Spastici 03.016
- Wilhelmina Kinderziekenhuis Onderzoekfonds 2003
- NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022
- Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.
- NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002
- NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103
- ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005
- ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes. 50-50200-98-060
Research Output (598)
Groenendaal Floris, van der Aa Niek Nov 2021, In: Journal of Pediatrics. 238 , p. 338-342 5 p.
Baak Lisanne M., Wagenaar Nienke, van der Aa Niek E., Groenendaal Floris, Dudink Jeroen, Tataranno Maria-Luisa, Smit Liesbeth S., Jellema Reint K., de Haan Timo R., ter Horst Henk J., de Boode Willem P., Steggerda Sylke J., de Haar Colin G., de Vries Linda S., van Bel Frank, Nijboer Cora H. A., Benders Manon J. N. L. Oct 2021, In: Pediatric Research. 90 , p. 8-8
Luzzati Michele, Coviello Caterina, Swarenburg-Veye Henriette, Dudink Jeroen, Dani Carlo, Koopmans Corine, deVries Linda S., Groenendaal Floris, Benders Manon, Tataranno Maria Luisa Oct 2021, In: Pediatric Research. 90 , p. 8-8
Hortensius Lisa M., Janson Els, van Beek Pauline E., Groenendaal Floris, Claessens Nathalie H.P., Swanenburg de Veye Henriette F.N., Eijsermans Maria J.C., Koopman-Esseboom Corine, Dudink Jeroen, van Elburg Ruurd M., Benders Manon J.N.L., Tataranno Maria Luisa, van der Aa Niek E. 27 Sep 2021, In: Nutrients. 13
Cizmeci Mehmet N., de Vries Linda S., Tataranno Maria Luisa, Zecic Alexandra, van de Pol Laura A., Alarcon Ana, Groenendaal Floris, Woerdeman Peter A. 17 Sep 2021, In: Journal of Neurosurgery: Pediatrics. 28 , p. 695-702 8 p.
van Hoorn Fieke, de Wit Leon, van Rossem Lenie, Jambroes Marielle, Groenendaal Floris, Kwee Anneke, Lamain-de Ruiter Marije, Franx Arie, van Rijn Bas B, Koster Maria P H, Bekker Mireille N Sep 2021, In: PLoS ONE. 16
Trzcionkowska Kasia, Groenendaal Floris, Andriessen Peter, Dijk Peter H, van den Dungen Frank A M, van Hillegersberg Jacqueline L, Koole Sanne, Kornelisse René F, van Westering-Kroon Elke, von Lindern Jeanette S, Meijssen Clemens B, Schuerman Frank A B A, Steiner Katerina, van Tuyl Minke W G, Witlox Ruben S G M, Schalij-Delfos Nicoline E, Termote Jacqueline U M 22 Jul 2021, In: Neonatology. 118 , p. 462-469 8 p.
van Hoorn Fieke, Koster Maria P H, Kwee Anneke, Groenendaal Floris, Franx Arie, Bekker Mireille N, 13 Apr 2021, In: BMC Pregnancy and Childbirth. 21
Gallo Dario, de Bijl-Marcus Karen A, Alderliesten Thomas, Lilien Marc, Groenendaal Floris 29 Mar 2021, In: Neonatology. 118 , p. 174-179 6 p.
Annink Kim V, de Vries Linda S, Groenendaal Floris, Eijsermans Rian M J C, Mocking Manouk, van Schooneveld Monique M J, Dudink Jeroen, van Straaten Henrica L M, Benders Manon J N L, Lequin Maarten, van der Aa Niek E 3 Mar 2021, In: Scientific Reports. 11 , p. 1-12