drs. U.V. (Sjoerd) Sikkes

drs. U.V. (Sjoerd) Sikkes

Associate Professor
drs. U.V. (Sjoerd) Sikkes
  • Epi Kanker Team C
  • Julius Center Research Program Cancer
  • Julius Center Research Program Cancer

Research Programs

Strategic Program Cancer



I obtained my MSc in Clinical Epidemiology at the Netherlands Institute for Health Sciences (2002), and my PhD at Utrecht University (2003). Following graduation from Medical School in 2005 I worked as a resident in radiology (Gelre Ziekenhuizen Apeldoorn, the Netherlands, 2006-2007). A personal Dutch Cancer Society Research Fellowship (2009-2013) enabled me to work as a visiting scientist at the Molecular Imaging Program at Stanford (professor SS Gambhir), the Department of Radiology and Biomedical Imaging at the University of California San Francisco (professor NM Hylton), and the Department of Molecular Pathology at the Netherlands Cancer Institute (professor LJ van't Veer). Since 2008, I work as a Clinical Epidemiologist in the research programs Cancer and Methodology at the Julius Center for Health Sciences and Primary Care, since 2018 as Associate Professor. Furthermore, I have more than ten years of experience in teaching and coordinating courses in clinical epidemiology, both nationally as well as internationally. Since 2020 I am coordinator of the PhD program Clinical and Translational Oncology, and since 2021 I am coordinator of the Research Program Cancer and management team member of the Epidemiology department of the Julius Center, as well as board member of the UMC Utrecht Strategic Program Cancer.

Interests and Focus

My main research focus is on the clinical evaluation and translation of biomarkers, particularly for cancer classification (i.e. diagnostic, prognostic, and predictive markers). These markers include emerging imaging technologies such as molecular imaging, omics-based tests, and organoids. I have both experience in preclinical research as well as applied clinical science, and have expertise and experience in the design and analysis of studies spanning all (translation) phases of biomarker development, as well as treatment studies (from phase I through phase III).

Side Activities

- Board member of the UMC Utrecht Strategic Program Cancer.

- Coordinator of the Research Program Cancer of the Julius Center.

- Coordinator of the PhD program Clinical and Translational Oncology.

- Coordinator of the SUMMA course "Wetenschappelijke Vorming - Onderzoeksmethodologie" ("applied clinical research").

- Coordinator of the MSc Epidemiology course "Advanced Topics in Causal Research: Confounding and Effect-Modification".

- Member of the Internal Review Committee Exploration of the Dutch Cancer Society.

- Member of the Dutch Association for Epidemiology (Vereniging voor Epidemiologie), Registration as Senior Epidemiologist (B) (SMBWO, 2006).

Fellowship and Awards

2022: Voted best lecturer of the year by the Selective Utrecht Medical Master program students, Utrecht University

2016-2017: Jury member of the Talma Eykman award, UMC Utrecht.

2016-2017: Jury member of the Frits de Waard Penning, UMC Utrecht.

2014: Epidemiology teacher of the year, Epidemiology department, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht.

2014: Voted best lecturer of the year by the Selective Utrecht Medical Master program students, Utrecht University.

2013-2016: Methodologist of the Medical Ethical Review Board of the UMC Utrecht.

2013: UMC Utrecht Research Talent Program.

2012: Invitee, 2nd Inspire2Live annual conference at the Royal Netherlands Academy of Arts and Sciences (meeting of talented young international cancer scientists).

2011: René Vogels Foundation travel grant.

2009: Dutch Cancer Society Research Fellowship (four year personal grant).

Research Output (176)

External Validation of Two Established Clinical Risk Scores Predicting Outcome after Local Treatment of Colorectal Liver Metastases in a Nationwide Cohort

Bolhuis Karen, Wensink G. Emerens, Elferink Marloes A.G., Bond Marinde J.G., Dijksterhuis Willemieke P.M., Fijneman Remond J.A., Kranenburg Onno W., Borel Rinkes Inne H.M., Koopman Miriam, Swijnenburg Rutger Jan, Vink Geraldine R., Hagendoorn Jeroen, Punt Cornelis J.A., Elias Sjoerd G., Roodhart Jeanine M.L. 2 May 2022, In: Cancers. 14 , p. 1-17

Population-based estimates of overtreatment with adjuvant systemic therapy in early breast cancer patients with data from the Netherlands and the USA

Ragusi M.A.A., van der Velden B.H.M., van Maaren M.C., van der Wall E., van Gils C. H., Pijnappel R. M., Gilhuijs K.G.A., Elias S.G. 2022, In: Breast Cancer Research and Treatment. 193 , p. 161-173 13 p.

Full-Thickness Scar Resection after R1/Rx Excised T1 Colorectal Cancers as an Alternative to Completion Surgery

Gijsbers Kim M, Laclé Miangela M, Elias Sjoerd G, Backes Yara, Bosman Joukje H, van Berkel Annemarie M, Boersma Femke, Boonstra Jurjen J, Bos Philip R, Dekker Patty, Didden Paul D, Geesing Joost M J, Groen John N, Haasnoot Krijn J C, Kessels Koen, van Lent Anja U G, van der Schee Lisa, Schrauwen Ruud W M, Schreuder Ramon-Michel, Schwartz Matthijs P, Seerden Tom J, Spanier Marcel B W M, Terhaar Sive Droste Jochim S, Tuynman Jurriaan B, de Vos Tot Nederveen Cappel Wouter H, van Westreenen Erik H L, Wolfhagen Frank H J, Vleggaar Frank P, Ter Borg Frank, Moons Leon M G, 31 Dec 2021, In: American Journal of Gastroenterology. 117 , p. 647-653 7 p.

Development and validation of a lifestyle-based model for colorectal cancer risk prediction:the LiFeCRC score

Aleksandrova Krasimira, Reichmann Robin, Kaaks Rudolf, Jenab Mazda, Bueno-de-Mesquita H Bas, Dahm Christina C, Eriksen Anne Kirstine, Tjønneland Anne, Artaud Fanny, Boutron-Ruault Marie-Christine, Severi Gianluca, Hüsing Anika, Trichopoulou Antonia, Karakatsani Anna, Peppa Eleni, Panico Salvatore, Masala Giovanna, Grioni Sara, Sacerdote Carlotta, Tumino Rosario, Elias Sjoerd G, May Anne M, Borch Kristin B, Sandanger Torkjel M, Skeie Guri, Sánchez Maria-Jose, Huerta José María, Sala Núria, Gurrea Aurelio Barricarte, Quirós José Ramón, Amiano Pilar, Berntsson Jonna, Drake Isabel, van Guelpen Bethany, Harlid Sophia, Key Tim, Weiderpass Elisabete, Aglago Elom K, Cross Amanda J, Tsilidis Konstantinos K, Riboli Elio, Gunter Marc J Dec 2021, In: BMC Medicine. 19 , p. 1-19

Contralateral parenchymal enhancement on MRI is associated with tumor proteasome pathway gene expression and overall survival of early ER+/HER2-breast cancer patients

Ragusi Max A A, Bismeijer Tycho, van der Velden Bas H M, Loo Claudette E, Canisius Sander, Wesseling Jelle, Wessels Lodewyk F A, Elias Sjoerd G, Gilhuijs Kenneth G A 2 Nov 2021, In: The Breast. 60 , p. 230-237 8 p.

De behandeling van oudere vrouwen met borstkanker

Scholten Astrid N, Schröder Carolien P, Elias Sjoerd G, Liefers Gerrit Jan 14 Oct 2021, In: Nederlands Tijdschrift voor Geneeskunde. 165

Sixty-Day Mortality of Patients With Metastatic Colorectal Cancer Randomized to Systemic Treatment vs Primary Tumor Resection Followed by Systemic Treatment:The CAIRO4 Phase 3 Randomized Clinical Trial

van der Kruijssen Dave E W, Elias Sjoerd G, Vink Geraldine R, van Rooijen Karlijn L, 't Lam-Boer Jorine, Mol Linda, Punt Cornelis J A, de Wilt Johannes H W, Koopman Miriam, 6 Oct 2021, In: JAMA Surgery. 156 , p. 1093-1101 9 p.

Effects of exercise in breast cancer patients:implications of the trials within cohorts (TwiCs) design in the UMBRELLA Fit trial

Gal Roxanne, Monninkhof Evelyn M, van Gils Carla H, Groenwold Rolf H H, Elias Sjoerd G, van den Bongard Desirée H J G, Peeters Petra H M, Verkooijen Helena M, May Anne M 24 Aug 2021, In: Breast Cancer Research and Treatment. 190 , p. 89-101 13 p.

Role of Up-Front Primary Tumor Resection and Tumor Sidedness in the Survival of Synchronous Metastatic Colon Cancer Patients

van der Kruijssen Dave E W, van Rooijen Karlijn L, Kurk Sophie A, de Wilt Johannes HW, Punt Cornelis J A, Vink Geraldine R, Elias Sjoerd G, Koopman Miriam 28 Jul 2021, In: Digestive Surgery. 38 , p. 283-289 7 p.

First-in-Human Study of the Biodistribution and Pharmacokinetics of Zr-89-CX-072, a Novel Immunopet Tracer Based on an Anti-PD-L1 Probody

Kist de Ruijter Laura, Hooiveld-Noeken Jahlisa S, Giesen Danique, Lub-de Hooge Marjolijn N, Kok Iris C, Brouwers Adrienne H, Elias Sjoerd G, Nguyen Margaret T L, Lu Hong, Gietema Jourik A, Jalving Mathilde, de Groot Derk J A, Vasiljeva Olga, de Vries Elisabeth G E 12 Jul 2021, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 27 , p. 5325-5333 9 p.

All research output

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