mr. ing. H.I.I. (Linde) Rijsdijk

mr. ing. H.I.I. (Linde) Rijsdijk

Full Professor
mr. ing. H.I.I. (Linde) Rijsdijk
  • Center for Translational Immunology (CTI)



Linde Meyaard obtained her PhD in 1995 (cum laude) at Sanquin in Amsterdam studying mechanism of immune dysfunction in HIV infection. In 1996 she entered the immune inhibitory receptor field as a post-doc at DNAX Research Institute in California. She identified a novel inhibitory immune receptor, LAIR-1, and continued her work on this receptor in as a fellow of the Royal Academy of Sciences (KNAW) in the UMC Utrecht.

Since 2000 she leads her own research group embedded in the Center Translational Immunology, supported by multiple grants such as the NWO Vidi and Vici. Meyaard was the first to identify collagens and collagen-like proteins as the natural ligands for LAIR-1. She then extended her research towards other inhibitory receptors and studies these inhibitory receptors in the context of cancer, inflammation and immunopathology of viral infections.

In 2016-2017 she spent a year as visiting scientist at Yale Medical School in the lab of Professor Ruslan Medzhitov. In 2018 she became a principle investigator at Oncode Institite for cancer research. Since september 2018 she is department head of the Center for Translational Immunology at the UMC Utrecht.

In her current work, Meyaard continues to ask fundamental immunological questions regarding inhibitory receptors to develop novel concepts that can be translated to clinic application. She proposed that inhibitory receptors can be grouped in functional categories with different purposes. Recently, her lab identified SIRL-1 as a receptor recognizing endogenous and microbial molecular patterns, introducing the concept of inhibitory pattern recognition receptors. Furthermore, they discovered that inflammation can rewire inhibitory signaling and influence the functional outcome. Together with clinicians, Meyaard translates these concepts to cancer and inflammation. By collaborating with multiple biotech and pharmaceutical companies she aims for clinical application of her work.

Side Activities

Investigator at Oncode Institute

Member of review panel ENW Open Program

Member of the ESCUlab review committee of the European Lead Factory

Collaborative research agreements with NextCure, NGM Biopharmaceuticals, Boehringer Ingelheim


Fellowship and Awards

1999-2001      Fellow of the Royal Dutch Academy of Science (KNAW)

2001                NWO Vidi

2002                NWO Aspasia

2014                NWO Vici

Research Output (115)

Inhibitory pattern recognition receptors

Rumpret Matevž, von Richthofen Helen J, Peperzak Victor, Meyaard Linde 14 Dec 2021, In: Journal of Experimental Medicine. 219

Signaling by the inhibitory receptor CD200R is rewired by type I interferon

van der Vlist Michiel, Pascoal Ramos M Inês , van den Hoogen Lucas L, Hiddingh Sanne, Timmerman Laura M, de Hond Titus A P, Kaan Ellen D, van der Kroef Maarten, Lebbink Robert Jan, Peters Florence M A, Khoury-Hanold William, Fritsch-Stork Ruth, Radstake Timothy R D J, Meyaard Linde 12 Oct 2021, In: Science Signaling [E]. 14 , p. 1-11

Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1

Vijver Saskia V., Singh Akashdip, Mommers-Elshof Eline T.A.M., Meeldijk Jan, Copeland Ronald, Boon Louis, Langermann Sol, Flies Dallas, Meyaard Linde, Ramos M. Inês Pascoal 7 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-13

Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic alpha-helical peptides

Rumpret Matevž, von Richthofen Helen J., van der Linden Maarten, Westerlaken Geertje H.A., Talavera Ormeño Cami, van Strijp Jos A.G., Landau Meytal, Ovaa Huib, van Sorge Nina M., Meyaard Linde Oct 2021, In: FASEB Journal. 35 , p. 1-19 19 p.

Recognition of S100 proteins by Signal Inhibitory Receptor on Leukocytes-1 negatively regulates human neutrophils

Rumpret Matevž, von Richthofen Helen J., van der Linden Maarten, Westerlaken Geertje H.A., Talavera Ormeño Cami, Low Teck Y., Ovaa Huib, Meyaard Linde 30 Jun 2021, In: European Journal of Immunology. 51 , p. 2210-2217 8 p.

Cancer immunotherapy by nc410, a lair-2 fc protein blocking human lair-collagen interaction

Ramos M. Ines Pascoal, Tian Linjie, de Ruiter Emma J., Song Chang, Paucarmayta Ana, Singh Akashdip, Elshof Eline, Vijver Saskia V., Shaik Jahangheer, Bosiacki Jason, Cusumano Zachary, Jensen Christina, Willumsen Nicholas, Karsdal Morten A., Liu Linda, Langermann Sol, Willems Stefan, Flies Dallas, Meyaard Linde 14 Jun 2021, In: eLife. 10 , p. 1-29

Identification of a novel conserved signaling motif in CD200 receptor required for its inhibitory function

Timmerman Laura M., De Graaf J. Fréderique, Satravelas Nikolaos, Kesmir Çan, Meyaard Linde, Van Der Vlist Michiel 29 Mar 2021, In: PLoS ONE. 16 16 p.

CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils

Pascoal Ramos M Inês, Keşmir Can, Stok Jorn E., Geerdink Ruben, Satravelas Nikolaos, Westerlaken Geertje H.A., Meyaard Linde, van der Vlist Michiel 2021, In: Journal of Leukocyte Biology. 111 , p. 367-377 11 p.

Transcriptome of airway neutrophils reveals an interferon response in life-threatening respiratory syncytial virus infection

Besteman Sjanna B., Callaghan Amie, Langedijk Annefleur C., Hennus Marije P., Meyaard Linde, Mokry Michal, Bont Louis J., Calis Jorg J.A. Nov 2020, In: Clinical Immunology. 220 , p. 1-10

Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon

von Richthofen Helen J., Gollnast Doron, van Capel Toni M.M., Giovannone Barbara, Westerlaken Geertje H.A., Lutter Lisanne, Oldenburg Bas, Hijnen Dirk Jan, van der Vlist Michiel, de Jong Esther C., Meyaard Linde 28 Aug 2020, In: Cellular Immunology. 357

All research output

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