mr. ing. H.I.I. (Linde) Rijsdijk
mr. ing. H.I.I. (Linde) Rijsdijk
- Center for Translational Immunology (CTI)
Research Programs
Biography
Biography
Linde Meyaard obtained her PhD in 1995 (cum laude) at Sanquin in Amsterdam studying mechanism of immune dysfunction in HIV infection. In 1996 she entered the immune inhibitory receptor field as a post-doc at DNAX Research Institute in California. She identified a novel inhibitory immune receptor, LAIR-1, and continued her work on this receptor in as a fellow of the Royal Academy of Sciences (KNAW) in the UMC Utrecht.
Since 2000 she leads her own research group embedded in the Center Translational Immunology, supported by multiple grants such as the NWO Vidi and Vici. Meyaard was the first to identify collagens and collagen-like proteins as the natural ligands for LAIR-1. She then extended her research towards other inhibitory receptors and studies these inhibitory receptors in the context of cancer, inflammation and immunopathology of viral infections.
In 2016-2017 she spent a year as visiting scientist at Yale Medical School in the lab of Professor Ruslan Medzhitov. In 2018 she became a principle investigator at Oncode Institite for cancer research. Since september 2018 she is department head of the Center for Translational Immunology at the UMC Utrecht.
In her current work, Meyaard continues to ask fundamental immunological questions regarding inhibitory receptors to develop novel concepts that can be translated to clinic application. She proposed that inhibitory receptors can be grouped in functional categories with different purposes. Recently, her lab identified SIRL-1 as a receptor recognizing endogenous and microbial molecular patterns, introducing the concept of inhibitory pattern recognition receptors. Furthermore, they discovered that inflammation can rewire inhibitory signaling and influence the functional outcome. Together with clinicians, Meyaard translates these concepts to cancer and inflammation. By collaborating with multiple biotech and pharmaceutical companies she aims for clinical application of her work.
Side Activities
Investigator at Oncode Institute
Member of review panel ENW Open Program
Member of the ESCUlab review committee of the European Lead Factory
Collaborative research agreements with NextCure, NGM Biopharmaceuticals, Boehringer Ingelheim
Fellowship and Awards
1999-2001 Fellow of the Royal Dutch Academy of Science (KNAW)
2001 NWO Vidi
2002 NWO Aspasia
2014 NWO Vici
Research Output (115)
Rumpret Matevž, von Richthofen Helen J, Peperzak Victor, Meyaard Linde 14 Dec 2021, In: Journal of Experimental Medicine. 219
van der Vlist Michiel, Pascoal Ramos M Inês , van den Hoogen Lucas L, Hiddingh Sanne, Timmerman Laura M, de Hond Titus A P, Kaan Ellen D, van der Kroef Maarten, Lebbink Robert Jan, Peters Florence M A, Khoury-Hanold William, Fritsch-Stork Ruth, Radstake Timothy R D J, Meyaard Linde 12 Oct 2021, In: Science Signaling [E]. 14 , p. 1-11
Vijver Saskia V., Singh Akashdip, Mommers-Elshof Eline T.A.M., Meeldijk Jan, Copeland Ronald, Boon Louis, Langermann Sol, Flies Dallas, Meyaard Linde, Ramos M. Inês Pascoal 7 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-13
Rumpret Matevž, von Richthofen Helen J., van der Linden Maarten, Westerlaken Geertje H.A., Talavera Ormeño Cami, van Strijp Jos A.G., Landau Meytal, Ovaa Huib, van Sorge Nina M., Meyaard Linde Oct 2021, In: FASEB Journal. 35 , p. 1-19 19 p.
Rumpret Matevž, von Richthofen Helen J., van der Linden Maarten, Westerlaken Geertje H.A., Talavera Ormeño Cami, Low Teck Y., Ovaa Huib, Meyaard Linde 30 Jun 2021, In: European Journal of Immunology. 51 , p. 2210-2217 8 p.
Ramos M. Ines Pascoal, Tian Linjie, de Ruiter Emma J., Song Chang, Paucarmayta Ana, Singh Akashdip, Elshof Eline, Vijver Saskia V., Shaik Jahangheer, Bosiacki Jason, Cusumano Zachary, Jensen Christina, Willumsen Nicholas, Karsdal Morten A., Liu Linda, Langermann Sol, Willems Stefan, Flies Dallas, Meyaard Linde 14 Jun 2021, In: eLife. 10 , p. 1-29
Timmerman Laura M., De Graaf J. Fréderique, Satravelas Nikolaos, Kesmir Çan, Meyaard Linde, Van Der Vlist Michiel 29 Mar 2021, In: PLoS ONE. 16 16 p.
Pascoal Ramos M Inês, Keşmir Can, Stok Jorn E., Geerdink Ruben, Satravelas Nikolaos, Westerlaken Geertje H.A., Meyaard Linde, van der Vlist Michiel 2021, In: Journal of Leukocyte Biology. 111 , p. 367-377 11 p.
Besteman Sjanna B., Callaghan Amie, Langedijk Annefleur C., Hennus Marije P., Meyaard Linde, Mokry Michal, Bont Louis J., Calis Jorg J.A. Nov 2020, In: Clinical Immunology. 220 , p. 1-10
von Richthofen Helen J., Gollnast Doron, van Capel Toni M.M., Giovannone Barbara, Westerlaken Geertje H.A., Lutter Lisanne, Oldenburg Bas, Hijnen Dirk Jan, van der Vlist Michiel, de Jong Esther C., Meyaard Linde 28 Aug 2020, In: Cellular Immunology. 357