prof. dr. U. (Hanneke L.D.M.) Nijs

prof. dr. U. (Hanneke L.D.M.) Nijs

Assistant Professor
prof. dr. U. (Hanneke L.D.M.) Nijs
  • Center for Translational Immunology (CTI) Research

Research Programs

Infection & Immunity



Hanneke Willemen was born on March 21th, 1982 in Den Bosch. She studied Biotechnology at Wageningen University and in 2006 she received her Master’s degree with specialization cellular/molecular research. In 2006 she started working as a research technician at the Laboratory of Psychoneuroimmunology (PNI). In 2008 she started her PhD-project in the PNI-lab to studyneurobiological mechanisms underlying the transition from acute to chronic inflammation-induced pain under supervision of Professor Heijnen, Professor Kavelaars and Dr. Eijkelkamp. In 2013 this work resulted in her PhD thesis: “Chronic inflammatory pain: New molecules & mechanisms”. After completing her PhD she continued her research as a postdoc in the Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD) under supervision of Dr. Eijkelkamp. She investigated the genetic contribution to chronic pain and identified an unidentified protein which has a key role to promote the development of chronic pain. In search for the molecular function of this protein she recently worked in the lab of Professor Falnes, Oslo University (Norway) for 3 months. In 2018 she was rewarded with a VENI (NWO) to study whether targeting mitochondria is a novel way to treat chronic pain. Currently she is working on this project in the neuro-immunulogy group (Dr. Eijkelkamp) at Center for Translational Immunology. 

Side Activities

UMCU young academy

Fellowship and Awards

Defeating chronic pain. Centre for unusual collaborations (2021)

VENI (2018)

3V's: Pain-in-a-dish (2017) 

EMBO short-term fellowship (2014)

Boehringer Ingelheim Fonds (2013)

Research Output (38)

Anti-GD2 IgA kills tumors by neutrophils without antibody-associated pain in the preclinical treatment of high-risk neuroblastoma

Evers Mitchell, Stip Marjolein, Keller Kaylee, Willemen Hanneke, Nederend Maaike, Jansen Marco, Chan Chilam, Budding Kevin, Nierkens Stefan, Valerius Thomas, Meyer-Wentrup Friederike, Eijkelkamp Niels, Leusen Jeanette 29 Oct 2021, In: Journal for ImmunoTherapy of Cancer. 9 , p. 1-14

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

Davydova Erna, Shimazu Tadahiro, Schuhmacher Maren Kirstin, Jakobsson Magnus E, Willemen Hanneke L D M, Liu Tongri, Moen Anders, Ho Angela Y Y, Małecki Jędrzej, Schroer Lisa, Pinto Rita, Suzuki Takehiro, Grønsberg Ida A, Sohtome Yoshihiro, Akakabe Mai, Weirich Sara, Kikuchi Masaki, Olsen Jesper V, Dohmae Naoshi, Umehara Takashi, Sodeoka Mikiko, Siino Valentina, McDonough Michael A, Eijkelkamp Niels, Schofield Christopher J, Jeltsch Albert, Shinkai Yoichi, Falnes Pål Ø 9 Feb 2021, In: Nature Communications. 12 14 p.

GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity

Vila-Bedmar Rocío, Cruces-Sande Marta, Arcones Alba C, Willemen Hanneke L D M, Prieto Patricia, Moreno-Indias Isabel, Díaz-Rodríguez Daniel, Francisco Sara, Jaén Rafael I, Gutiérrez-Repiso Carolina, Heijnen Cobi J, Boscá Lisardo, Fresno Manuel, Kavelaars Annemieke, Mayor Federico, Murga Cristina 11 Jan 2020, In: Cellular and Molecular Life Sciences. 77 , p. 4957-4976 20 p.

Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration

Małecki Jędrzej, Willemen Hanneke L D M, Pinto Rita, Ho Angela Y Y, Moen Anders, Eijkelkamp Niels, Falnes Pål Ø 18 Jun 2019, In: Journal of Biological Chemistry. 294 , p. 11654-11664 11 p.

Sensory signaling pathways in inflammatory and neuropathic pain

Willemen Hanneke L.D.M., Eijkelkamp Niels 2019,

Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase

Małecki Je drzej M., Willemen Hanneke L.D.M., Pinto Rita, Ho Angela Y.Y., Moen Anders, Kjønstad Ingrid F., Burgering Boudewijn M.T., Zwartkruis Fried, Eijkelkamp Niels, Falnes Pål 10 Dec 2018, In: Journal of Biological Chemistry. 294 , p. 1128-1141 14 p.

Divergent roles of immune cells and their mediators in pain

Raoof Ramin, Willemen Hanneke L.D.M., Eijkelkamp Niels 1 Mar 2018, In: Rheumatology (Oxford, England). 57 , p. 429-440 12 p.

Identification of FAM173B as a protein methyltransferase promoting chronic pain

Willemen Hanneke L.D.M., Kavelaars Annemieke, Prado Judith, Maas Mirjam, Versteeg Sabine, Nellissen Lara J.J., Tromp Jeshua, Gonzalez Cano Rafael, Zhou Wenjun, Jakobsson Magnus E., Małecki Jędrzej, Posthuma George, Habib Abdella M., Heijnen Cobi J., Falnes Pål, Eijkelkamp Niels 14 Feb 2018, In: PLoS Biology. 16

The neuronal mitochondrial methyltransferase FAM173B promotes glia activation and persistent pain

Willemen HLDM 2017,

Congres over mechanismes en behandelingen van pijn

Willemen HLDM Sep 2016, In: Patientenvereniging CRPS.

All research output

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